A5102895959- Pluripotent Stem Cells Research
- Receptor Mechanisms and Signaling
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- Mesenchymal stem cell research
- HER2/EGFR in Cancer Research
- Bone health and treatments
- Biochemical and Molecular Research
- Gut microbiota and health
- Immunotherapy and Immune Responses
- Pharmacogenetics and Drug Metabolism
- Machine Learning in Bioinformatics
- Renin-Angiotensin System Studies
- Genetic Associations and Epidemiology
- Rheumatoid Arthritis Research and Therapies
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Genetics, Aging, and Longevity in Model Organisms
- Diet, Metabolism, and Disease
- 3D Printing in Biomedical Research
- Bioinformatics and Genomic Networks
- Alkaline Phosphatase Research Studies
- Synthesis and Reactivity of Heterocycles
- Hematological disorders and diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
Daiichi-Sankyo (Japan)
2014-2024
Kyushu University
2010-2020
Wunschbaby Institut für Kinderwunsch
2020
Otsuka (Japan)
2019
Tokai University
2013-2014
Daiichi Sankyo (Germany)
2012-2013
National Institute of Advanced Industrial Science and Technology
2012-2013
Japan Science and Technology Agency
2012
RIKEN Advanced Science Institute
2012
Keio University
2012
Background PAR‐6, aPKC and PAR‐3 are polarity proteins that co‐operate in the establishment of cell Caenorhabditis elegans Drosophila embryos. We have recently shown mammalian is required for formation epithelia‐specific cell‐cell junctional structure. also revealed a PAR‐6 forms ternary complex with ASIP/PAR‐3, localizes at most apical end epithelial cells . Results The co‐localization ASIP/PAR‐3 observed during early stage polarization. In addition, over‐expression mutant CRIB/PDZ domain...
The risk of idiosyncratic drug toxicity (IDT) is great concern to the pharmaceutical industry. Current hypotheses based on retrospective studies suggest that occurrence IDT related covalent binding and daily dose. We determined 42 radiolabeled drugs in three test systems (human liver microsomes hepatocytes vitro rat vivo) assess IDT. On basis safety profiles given official documentation, tested were classified into categories safe, warning, black box withdrawn. each did not distinguish...
It has been suggested that IL-1 produces cartilage matrix degradation by metalloproteinases such as collagenase, and is regulated metalloproteinase inhibitors (TIMP). Therefore, the balance between collagenase TIMP an important factor for tissue destruction in inflammatory joints. In present study effects of cytokines on production chondrocytes well connective cells were studied. beta inhibited endothelial while enhancing synovial chondrocytes. addition, tumour necrosis factor-alpha...
Trastuzumab deruxtecan (DS-8201a) is an antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2) conjugated to topoisomerase I inhibitor (DXd) at drug-to-antibody ratio (DAR) 7-8. Here, we examined the pharmacokinetic (PK) profiles DS-8201a and DXd in cynomolgus monkeys, cross-reactive species. Following intravenous (iv) administration DS-8201a, linker was stable plasma, systemic exposure low. rapidly cleared following iv...
Many studies have shown that it is possible to use culture conditions direct the differentiation of murine embryonic stem (ES) cells into a variety cell types, including cardiomyocytes and neurons. However, molecular mechanisms control lineage commitment decisions by ES remain poorly understood. In this study, we investigated role 3 major mitogen-activated protein kinases (MAPKs: extracellular signal-regulated kinase, c-Jun N-terminal p38) in showed p38 MAPK-specific inhibitor SB203580...
Induced pluripotent stem cells (iPSCs) can be generated from patients with specific diseases by the transduction of reprogramming factors and useful as a cell source for transplantation therapy various impaired organs. However, low efficiency iPSC derived somatic (0.01-0.1%) is one major problems in field. The phosphoinositide 3-kinase (PI3K) pathway thought to important self-renewal, proliferation, maintenance embryonic (ESCs), but contribution this or its well-known negative regulator,...
During animal development, cells undergo dynamic changes in position and gene expression. A collection of quantitative information about morphological dynamics under a wide variety perturbations would provide rich resource for understanding the molecular mechanisms development. Here, we created database, Worm Developmental Dynamics Database (http://so.qbic.riken.jp/wddd/), which stores cell division early Caenorhabditis elegans embryos with single genes silenced by RNA-mediated interference....
Abstract Brain and retinal capillary endothelial cells (BCECs RCECs, respectively) exhibit a barrier structure function. Comparison of gene expression in these could clarify the selective function each barrier. The purpose this study was to identify genes selectively expressed at blood–brain (BBB) gene, androgen receptor (AR). Gene compared by differential display using conditionally immortalized rat BCECs RCECs (TR‐BBB TR‐iBRB, respectively). A total 12 fragments were identified as...
H-InvDB (http://www.h-invitational.jp/) is a comprehensive human gene database started in 2004. In the latest version, 8.0, total of 244 709 complementary DNA was mapped onto hg19 reference genome and 43 829 loci, including nonprotein-coding ones, were identified. Of these 35 631 identified as potential protein-coding genes, 22 898 identical to known genes. our analysis, 19 309 annotated genes specific not found RefSeq Ensembl. fact, 233 turned out have protein functions this version...
Rheumatoid arthritis (RA) is a common autoimmune inflammatory disease of the joints and caused by both genetic environmental factors. In past six years, genome-wide association studies (GWASs) have identified many risk variants associated with RA. However, not all associations reported from GWASs are reproduced when tested in follow-up studies. To establish reliable set RA variants, we systematically classified degree reproducibility among independent We collected comprehensive 90 papers...
Abstract Trastuzumab deruxtecan (T‐DXd, DS‐8201a) is an antibody–drug conjugate, comprising anti‐HER2 antibody at a drug‐to‐antibody ratio of 7–8 with the topoisomerase I inhibitor DXd. In this study, concentrations antibody‐conjugated DXd and total were determined observed to decrease over time following intravenous administration T‐DXd monkeys. The also decreased in time‐dependent manner, which reached approximately 2.5 21 days after administration. It was suggested that relatively stable...
H-Invitational Database (H-InvDB; http://hinv.jp/) is an integrated database of all human genes and transcripts that started in international collaborative research project for establishing a functional annotation full-length cDNAs. Because H-InvDB contains abundance information transcripts, including not only well-characterized protein-coding but also those without experimental evidence at the protein level, this will be useful resource identifying novel uncharacterized proteins (so-called...
Recent generation of induced pluripotent stem ( iPSC s) has made a significant impact on the field human regenerative medicine. Prior to clinical application s, testing their safety and usefulness must be carried out using reliable animal models various diseases. In order generate s from common marmoset (CM; Callithrix jacchus ), one most useful experimental animals, we have lentivirally transduced reprogramming factors, including POU5F1 (also known as OCT3/4), SOX2, KLF4, c‐MYC into CM...