A5100711486- Cancer Immunotherapy and Biomarkers
- Influenza Virus Research Studies
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Respiratory viral infections research
- Infection Control and Ventilation
- Ferroptosis and cancer prognosis
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Neonatal and fetal brain pathology
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- Immune cells in cancer
- Hepatitis C virus research
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cervical Cancer and HPV Research
- Mycobacterium research and diagnosis
- Multiple Myeloma Research and Treatments
- Epigenetics and DNA Methylation
- Frailty in Older Adults
- Gastric Cancer Management and Outcomes
Guilin Medical University
2022-2025
China Medical University
2017-2024
Dalian Medical University
2022-2024
Changzhou No.2 People's Hospital
2022-2024
Nanjing Medical University
2022-2024
Wuhan University of Science and Technology
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2024
University of Delaware
2022-2024
Heidelberg University
2022-2024
University Hospital Heidelberg
2022-2024
Both α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been implicated in the pathology of Parkinson's disease (PD). Although studies suggest that αSyn its missense mutant, A53T, preferentially accumulate mitochondria, mechanisms by which proteins regulate each other to trigger neuronal toxicity are poorly understood. ATP-dependent Clp protease (ClpP), a matrix protease, plays an important role regulating protein turnover bioenergetics activity. Here, we show level ClpP is...
The majority of patients with common malignancies are older adults. Intrinsic complex biological changes aging along inflammation, immunosenescence, age-associated chronic diseases, and extrinsic environmental psychosocial factors have significant impact on not only development behavior individual malignancies, but also physiologic reserve vulnerability who suffer from them. As a result, clinical practice geriatric oncology demands integration careful assessment management. This article...
Abstract Chronic stress refers to continuous emotional changes and psychological pressure that individuals experience when they are unable adjust stabilize the internal environment over an extended period. It can increase on endocrine mediators cytokines in circulation, as well tissues throughout hypothalamic-pituitary-adrenaline (HPA) axis sympathetic nervous system (SNS); thus, evolving of tumor. This review assesses several key issues, involving psychosocial factors, integrates clinical,...
Abstract Adult bone marrow mesenchymal stem cells (MSCs) can differentiate into several types of cells, including osteocytes, chondrocytes, and adipocytes, but also non‐mesenchymal such as neural under appropriate experimental conditions. Until now, many protocols for inducing neuro‐differentiation in MSCs vitro have been reported. But due to the differences MSCs' isolation culture conditions, results previous studies lacked consistency comparability. In this study, we induced...
Abstract Glioblastomas ( GBM s) are the most common of both benign and malignant primary brain tumours, in which inflammatory immunologic abnormalities involved. Interleukin‐17A IL ‐17A) plays an important role various diseases cancers. Several recent studies revealed that expression ‐17A was overexpressed human s tissue. However, accurate remains unclear. In this study, we aimed to explore effect on cell migration invasion mechanism by effects occurred. We found exogenous promoted...
Flavonoids are bioactive phenolic compounds widely present in plant food and used various nutraceutical, pharmaceutical, cosmetic products. However, recent studies showed rising concerns of endocrine disruptions developmental toxicities for many flavonoids. To understand the impacts flavonoid structure on toxicity, we a new multitiered platform to investigate four common flavonoids, luteolin, apigenin, quercetin, genistein, from flavone, flavonol, isoflavone. Weak estrogenic activity was...
Cases of respiratory disease transmission in enclosed elevators have been reported frequently. In the post-pandemic era, order to mitigate spread diseases moving elevators, a multi-objective genetic optimization method based on response surface model is used optimize elevator ventilation. The ventilation parameters were optimized for three objectives: reducing carbon dioxide concentration, maintaining human thermal comfort, and achieving energy conservation. First, established using...
Patients with cancer frequently receive immune-checkpoint inhibitors (ICIs), which may modulate immune responses to COVID-19 vaccines. Recently, cytokine release syndrome (CRS) was observed in a patient who received BTN162b2 vaccination under ICI treatment. Here, we analyzed adverse events and serum cytokines patients 23 different tumors undergoing (n = 64) or not 26) therapy prospectively planned German single-center cohort study 220). We did observe clinically relevant CRS (≥grade 2) after...
Cathepsin H (CatH) is a lysosomal cysteine protease with unique aminopeptidase activity. Its expression level increased in activated immune cells including dendritic cells, macrophages, and microglia. We have previously reported that CatH deficiency impairs toll-like receptor 3 (TLR3)-mediated activation of interferon regulatory factor (IRF3), the subsequent secretion (IFN)-β from cells. Furthermore, there increasing evidence IFN-β secreted microglia/macrophages has neuroprotective effects....
Fusobacterium nucleatum is an oral anaerobe prevalent in intrauterine infection associated with a wide spectrum of adverse pregnancy outcomes. We demonstrate here that F. triggers placental inflammation through maternal, rather than paternal, TLR4-mediated signaling. Elimination TLR4 from maternal endothelial cells alleviated and reduced fetal neonatal death, while elimination the hematopoietic had no effect. The inflammatory response followed spatiotemporal pattern, NF-κB activation...
DNA immunization has been used to induce either humoral or cellular immune responses against many antigens, including hepatitis C virus (HCV). In addition, immunizations can be enhanced modulated at the nucleotide level. Genetic were examined in BALB/c mice through use of plasmids and chimeric constructs encoding HCV core proteins B (HBV) precore (preC) regions. Plasmids truncated induced potent HCV; pcDNA3.0A-C154 produced a stronger antibody response than pcDNA3.0A-C191 ( P < 0.01)...
Glioblastoma (GBM) is characterized by low numbers of glioma-infiltrating lymphocytes (GIL) with a dysfunctional phenotype. Whether this phenotype fixed or can be reversed upon ex vivo culturing poorly understood. The aim study was to assess T cell receptor (TCR)-dynamics and -specificities as well determinants in vitro GIL expansion sequencing-based technologies functional assays explore the use for therapy. By means flow cytometry, functionality cultures assessed from 9 GBM patients. TCR...
Background Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis , is a major public health concern. Chemokines and their receptors, such as RANTES, CXCR3, CCR5, have been reported to play important roles in cell activation migration immune responses against TB infection. Methods To understand the correlations involving CCR5 gene variations, M. infection, progression, case-control study comprising 450 patients with 306 healthy controls from Chinese Han population was...