A5026414108- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Cholesterol and Lipid Metabolism
- Helicobacter pylori-related gastroenterology studies
- Genetically Modified Organisms Research
- Transgenic Plants and Applications
- Reproductive Physiology in Livestock
- Diabetes Treatment and Management
- Escherichia coli research studies
- Diet and metabolism studies
- High Altitude and Hypoxia
- Trace Elements in Health
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Fungal and yeast genetics research
- Pregnancy and preeclampsia studies
- Gastroesophageal reflux and treatments
- Muscle metabolism and nutrition
- Genetics and Physical Performance
- Mitochondrial Function and Pathology
- Fatty Acid Research and Health
- Reproductive System and Pregnancy
Shandong University
2025
Inner Mongolia Medical University
2023
Chengdu Military General Hospital
2015
University of Iowa
1994
National Institutes of Health
1979-1981
Institute of Art
1979-1981
St. Luke's Hospital
1975-1979
Columbia University
1979
Apolipoproteins synthesized by intestine were identified in mesenteric lymph and plasma collected from an animal preparation which exposure to ["Hlleucine was restricted the mucosal epithelial cells of a fat-transporting small intestinal segment in.situ.The released labeled chylomicrons very low density lipoproteins only into but high both lymph.Of 3H incorporated individual apolipoproteins, separated polyacrylamide gel electrophoresis, 25% recovered apolipoprotein B (apoB), 50% apoA-I, 21%...
Recent studies of circulating lipoproteins in man and the rat have shown that apolipoprotein B plasma exists two immunologically distinct forms with apparent M,, rat, approximately 335,000 (apoB336K) 240,000 (apoBz40~).With isolated, p.erfused organs single double isotope labeling methods uiuo ((1979) J. Biol.Chem 254, 7316), we now found liver produces both apoB variants abundance while small intestine apOBzroK but only trace amounts apOB335~.The hepatic a p ~B ~~~~/ o z ~~~ leucine...
Using two complementary methods developed and applied earlier in rats absorbing triacylglycerols, we have now determined the intestinal contribution of individual plasma apolipoproteins when rate lipid absorption is very low.After all dietary fat was withheld for 16-20 h, intestine produced -50% apolipoprotein A-I (apo-A-I) apo-A-N, similar to its during absorption.When were fed a fat-free diet 12 days and, addition, biliary diverted from 16 still -60% apo-A-1 only slightly less apo-A- N....
The yeast YAP1 gene encodes a transcriptional regulatory protein that utilizes basic region-leucine zipper (bZip) DNA-binding domain to recognize its cognate DNA element. A synthetic reporter containing SV40 AP-1 response element (ARE) cloned upstream of TRP5 promoter-lacZ fusion shows yAP-1-dependent transactivation in vivo. Recent work has shown changes the dosage this factor can dramatically alter ability cell tolerate host toxic agents including cadmium, cycloheximide, and sulfometuron...
Transmucosal transport rates for triolein in proximal and distal intestine were compared unanesthetized rats.Emulsified [ l-'4C]triolein together with bile pancreatic juice from donor rats was infused 6 hr into either the duodenum or midpoint of small at such a rate that absorption essentially complete both regions intestine.Lymph collected thoracic duct during infusion an additional 6-hr period.The decrease lymphatic output labeled fat found to follow simple exponential function all...
Palmitoylation is recognized as a prevalent posttranslational modification of proteins, which highlighted in recent studies key player regulating protein stability, subcellular localization, membrane transport, and other cellular biological processes. However, its role peri-implant osteogenesis under type 2 diabetes mellitus (T2DM) remains unclear. During this study, the vitro high-glucose model based on MC3T3-E1 cells demonstrated that environment markedly inhibited osteoblasts...
Apoproteins of chylomicrons, very low density lipoprotein (VLDL), and a + high fraction secreted by proximal distal rat small intestine into mesenteric lymph were examined during triglyceride (TG) absorption.Apoprotein output composition determined the turnover rates labeled non-apoB (soluble) apoproteins in fractions measured after an intraluminal [3H]leucine pulse stable TG transport lymph.The VLDL exceeded that chylomicrons absorption 45 pmol per hour.More was incorporated than decay...
The immunological control mechanism against cholera toxin (CT) in the small intestine of rats was studied vivo. CT binding to intestinal receptors determined by injected radiolabeled into loops rat and subsequently separating purified microvillus membranes from mucosal scrapings those loops. substantial radioactivity (10(5) cpm/mg protein) present fractions exposed 125I-labeled compared (10(2) cpm/mg) bovine serum albumin (BSA) used as a control. significantly inhibited (P less than 0.02)...
This study aimed to explore the relationship between genetic changes and high-altitude pulmonary edema (HAPE) susceptibility, screen for key single nucleotide polymorphism (SNP) loci in HAPE-susceptibility gene, by investigating SNPs occurring hypoxia-related genes HAPE-susceptible control (non-susceptible) populations.This research was conducted on Han recruits, who travelled Lhasa plateau (altitude, 3658 m).Ten located ten extracted from HAPE healthy populations were amplified polymerase...
Recurrent spontaneous abortion (RSA) is characterized by the occurrence of two or more consecutive abortions, with a rising prevalence among pregnant women and significant implications for their physical mental well-being. The multifaceted etiology RSA has posed challenges in unraveling molecular mechanisms underlying that underlie its pathogenesis. Oxidative stress immune response have been identified as pivotal factors development condition.Eleven serum samples from healthy 17 were...