A5082725259- DNA Repair Mechanisms
- Photosynthetic Processes and Mechanisms
- Agricultural Productivity and Crop Improvement
- Toxin Mechanisms and Immunotoxins
- CRISPR and Genetic Engineering
- Wheat and Barley Genetics and Pathology
- Plant tissue culture and regeneration
Huazhong Agricultural University
2023-2025
Chinese Academy of Agricultural Sciences
2023-2025
Key Laboratory of Guangdong Province
2023-2025
Agricultural Genomics Institute at Shenzhen
2023-2025
Shanghai Zhangjiang Laboratory
2023
Abstract DNA replication stress threatens genome stability and is a hallmark of cancer in humans. The evolutionarily conserved kinases ATR (ATM RAD3-related) WEE1 are essential for the activation responses. Translational control an important mechanism that regulates gene expression, but its role responses largely unknown. Here we show ATR–WEE1 translation SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1), master transcription factor required Arabidopsis thaliana. Through genetic screening, found loss...
Genetic screening in Arabidopsis reveals that clathrin, a well-known regulator of endocytosis, is required for homologous recombination, precise mechanism repairing DNA double- strand breaks. Notably, CLATHRIN LIGHT CHAIN 2 localizes the nucleus, suggesting clathrin has non-canonical functions nucleus.