A5101735366- Malaria Research and Control
- Mosquito-borne diseases and control
- Cancer Research and Treatments
- Advanced Glycation End Products research
- Trypanosoma species research and implications
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Complement system in diseases
- Cancer Immunotherapy and Biomarkers
- Traditional and Medicinal Uses of Annonaceae
- Vibrio bacteria research studies
- Immunotherapy and Immune Responses
Regional Centre for Biotechnology
2023-2024
Institute of Life Sciences
2021-2024
Heme-biosynthetic pathway of malaria parasite is dispensable for asexual stages, but essential mosquito and liver stages. Despite having backup mechanisms to acquire hemoglobin-heme, intermediates and/or enzymes from the host, parasites express heme synthesize heme. Here we show synthesized in stages promotes cerebral pathogenesis by enhancing hemozoin formation. Hemozoin a molecule associated with inflammation, aberrant host-immune responses, disease severity pathogenesis. The knockout less...
Abstract Malaria parasite lacks canonical pathways for amino acid biosynthesis and depends primarily on hemoglobin degradation extracellular resources acids. Interestingly, a putative gene glutamine synthetase (GS) is retained despite being an abundant in human mosquito hosts. Here we show Plasmodium GS has evolved as unique type I enzyme with distinct structural regulatory properties to adapt the asexual niche. Methionine sulfoximine (MSO) phosphinothricin (PPT) inhibit activity. localized...
The food vacuole plays a central role in the blood stage of parasite development by digesting host hemoglobin acquired from red cells and detoxifying heme released during digestion into hemozoin. Blood-stage parasites undergo periodic schizont bursts, releasing vacuoles containing Clinical studies malaria-infected patients vivo animal have shown association hemozoin with disease pathogenesis abnormal immune responses malaria. Here, we perform detailed characterization putative Plasmodium...
Abstract CD4 T cells have long been known to be critical for priming CD8 cells, a process referred as cell help. Recent data suggested that help may delivered at the surface of conventional type 1 dendritic (cDC1s), which can efficiently present antigens (Ag) on both MHC class I and II molecules. However, actual mechanisms underlying remain poorly characterized. We sought understand how anti-tumor responses are generated in context mRNA vaccines, shown elicit protective and/or cells. For...
ABSTRACT Heme-biosynthetic pathway of malaria parasite is dispensable for asexual stages, but essential sexual and liver stages. Despite having backup mechanisms to acquire hemoglobin-heme, intermediates and/or enzymes from the host, parasites express heme synthesize heme. Here we show synthesized in stages promotes cerebral pathogenesis by enhancing hemozoin formation. Hemozoin a molecule associated with inflammation, aberrant host-immune responses, disease severity pathogenesis. The...