A5058051870- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Hemoglobinopathies and Related Disorders
- Acute Lymphoblastic Leukemia research
- Blood groups and transfusion
- Sarcoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Iron Metabolism and Disorders
- Bone and Joint Diseases
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
Dana-Farber Cancer Institute
2017-2025
Toyama University Hospital
2021-2024
University of Toyama
2020-2023
Harvard University
2017-2021
Toyama College
2021
National Cancer Center Hospital East
2019
Sapporo Medical University
2011-2017
Oji General Hospital
2013-2015
Hakodate National Hospital
2010-2012
Axicabtagene ciloleucel (axi-cel) was approved by the Food and Drug Administration for relapsed aggressive B-cell non-Hodgkin lymphoma in part on basis of durable remission rates approximately 40% a clinical trial population. Whether this efficacy, toxicity, would be consistent postcommercial setting, with relaxed eligibility criteria bridging therapy, is unknown. This study describes efficacy safety correlates outcomes setting.
Effective therapies for non-small cell lung cancer (NSCLC) remain challenging despite an increasingly comprehensive understanding of somatically altered oncogenic pathways. It is now clear that therapeutic agents with potential to impact the tumor immune microenvironment potentiate immune-orchestrated benefit. Herein, we evaluated immunoregulatory properties histone deacetylase (HDAC) and bromodomain inhibitors, two classes drugs modulate epigenome, a focus on key subsets are engaged in...
The combination of glutamine, fiber and oligosaccharides (GFO) is thought to be beneficial for alleviating gastrointestinal mucosal damage caused by chemotherapy. A commercial enteral supplementation product enriched with these 3 components available in Japan. We performed a retrospective study test whether oral GFO decreased the severity injury following hematopoietic stem cell transplantation (HSCT). Of 44 HSCT patients, 22 received did not. Severity diarrhea/mucositis, overall survival,...
The failure of normal hematopoiesis is observed in myeloid neoplasms. However, the precise mechanisms governing replacement hematopoietic stem cells their niche by neoplasm have not yet been clarified. Primary acute leukemia and myelodysplastic syndrome induced aberrant expression multiple factors including Jagged-1, cell factor angiopoietin-1 mesenchymal even non-contact conditions, this abnormality was reverted extracellular vesicle inhibition. Importantly, transfer neoplasm-derived...
CAR T cell approaches to effectively target AML and T-ALL without off-tumor effects on healthy myeloid or compartments respectively are an unmet medical need. NKG2D-ligands a promising given their absence cells surface expression in wide range of malignancies. NKG2D-ligand has been reported substantial group patients with along evidence for prognostic significance. However, reports regarding the prevalence density vary detailed studies define whether low level is sufficient trigger directed...
Impaired interleukin-2 (IL-2) production and regulatory T-cell dysfunction have been implicated as immunological mechanisms central to the pathogenesis of multiple autoimmune inflammatory diseases. NKTR-358, a novel stimulator, is an investigational therapeutic that selectively restores homeostasis in these We investigated NKTR-358's selectivity for T-cells, receptor-binding properties, ex vivo pharmacodynamics, ability suppress conventional proliferation mice non-human primates, functional...
Aberrant reactivation of hedgehog (Hh) signaling has been described in a wide variety human cancers including cancer stem cells. However, involvement the Hh-signaling system bone marrow (BM) microenvironment during development myeloid neoplasms is unknown. In this study, we assessed expression Hh-related genes primary CD34(+) cells, blastic cells and BM stromal Both Indian Hh (Ihh) its signal transducer, smoothened (SMO), were expressed acute leukemia (AML) myelodysplastic syndrome...
Deregulated iron metabolism underlies the pathogenesis of many human cancers. Recently, low expression ferroportin, which is only identified non-heme exporter, has been associated with significantly reduced overall survival in multiple myeloma (MM); however, altered MM biology remains unclear. In this study we demonstrated, by live cell imaging, that cells have increased intracellular levels as compared normal cells. experiments to test effect chelation on growth cells, found deferasirox...
Abstract Dipeptidyl peptidases (DPPs) are proteolytic enzymes that ideal therapeutic targets in human diseases. Indeed, DPP4 inhibitors widely used clinical practice as anti-diabetic agents. In this paper, we show also induced cell death multiple myeloma cells. Among five inhibitors, only two of them, vildagliptin and saxagliptin, exhibited apparent cytotoxic effects on lines, without any difference suppression activity. As these known to have off-target against DPP8/9, employed the specific...
Background: CAR-T cell therapy provides transformative outcomes for patients with relapsed/refractory (R/R) large B lymphoma (LBCL). However, a fraction of remains at risk relapse, underlying the need to uncover mechanisms resistance and predictive biomarkers. We leveraged ZUMA-1, -6 -7 studies R/R LBCL discover product features associated outcome [Axicabtagene Ciloleucel (axi-cel)]. explored ligand-receptor interactions between cells tumor microenvironment, identifying CD27-CD70 TIGIT-PVR...
Reactive oxygen species (ROS) are normal byproducts of a wide variety cellular processes. ROS have dual functional roles in cancer cell pathophysiology. At low to moderate levels, act as signaling transducers activate proliferation, migration, invasion, and angiogenesis. In contrast, high levels induce death. multiple myeloma (MM), overproduction is the trigger for apoptosis induced by several anticancer compounds, including proteasome inhibitors. However, no drugs which oxidative stress...
Rituximab is a drug used for the treatment of B-cell non-Hodgkin's lymphoma, and its range use has expanded to collagen diseases such as idiopathic thrombocytopenic purpura rheumatoid arthritis. One serious complication rituximab reactivation dormant hepatitis B virus, prevention this phenomenon become an urgent issue. This paper provides general outline problem through analysis patient cases that we other groups have experienced date.
The prognosis of advanced hepatocellular carcinoma (HCC) is dismal, underscoring the need for novel effective treatments. α1,6-fucosyltransferase (fucosyltransferase 8, FUT8) has been reported to accelerate malignant potential in HCC. Our study aimed investigate regulation FUT8 expression by p53 and develop a therapeutic strategy targeting HCC cells using L-fucose-mediated drug delivery.Binding sites were searched within promoter region. was assessed immunoblotting. Chromatin...
Chimeric-antigen-receptor (CAR) T-cell therapy for CD19-expressing B-cell malignancies is already widely adopted in clinical practice. On the other hand, development of CAR-T-cell its nascent stage. One potential targets CD26, to which we have developed and evaluated efficacy safety humanized monoclonal antibody YS110. We generated second (CD28) third (CD28/4-1BB) generation CD26-targeted CAR-T-cells (CD26-2G/3G) using YS110 as single-chain variable fragment. When co-cultured with...
Relapsed or refractory Burkitt's lymphoma often has a poor prognosis in spite of intensive chemotherapy that induces apoptotic and/or necrotic death cells. Rapamycin (Rap) brings about autophagy, and could be another treatment. Further, anti-CD19-targeted liposomal delivery may enable Rap to kill cells specifically. was encapsulated by anionic liposome conjugated with anti-CD19 antibody (CD19-GL-Rap) anti-CD2 (CD2-GL-Rap) as control. A fluorescent probe Cy5.5 also liposomized the same way...
Chronic disseminated intravascular coagulation (DIC) is a rare but life-threatening complication of dissecting aortic aneurysm. Although anticoagulant therapy may often proves effective for controlling DIC itself, patients would have to be hospitalized long period due continuous infusion therapy. Subcutaneous injection highly concentrated preparation heparin calcium offer one alternative treatment DIC; however, daily subcutaneous use the has impaired quality life (QOL). The other intravenous...
Narrowband ultraviolet B (NB-UVB) has been widely used in dermatological phototherapy. As for the application of NB-UVB phototherapy to graft-versus-host disease (GVHD), we previously reported that it was highly efficacious cutaneous lesions acute GVHD (aGVHD) and expansion regulatory T (Treg) cells induced by might be one mechanisms. In order examine whether irradiation through Treg is effective treatment not only aGVHD but also inner organs such as intestine or liver, conducted experiments...