A5081939873- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- Cardiac Arrhythmias and Treatments
- Infective Endocarditis Diagnosis and Management
- Organ Transplantation Techniques and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Cardiac tumors and thrombi
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Diaphragmatic Hernia Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sarcoma Diagnosis and Treatment
- Coronary Artery Anomalies
- Pericarditis and Cardiac Tamponade
- Pulmonary Hypertension Research and Treatments
- Cardiac and Coronary Surgery Techniques
- Vascular Anomalies and Treatments
- Infectious Aortic and Vascular Conditions
- Immune Response and Inflammation
- Shoulder and Clavicle Injuries
Westmead Hospital
2015-2025
Baylor College of Medicine
2013-2025
Texas Children's Hospital
2013-2025
Children's Hospital at Westmead
2015-2024
The University of Sydney
2017-2024
Sydney Children’s Hospitals Network
2013-2024
Australian Centre for Heart Health
2024
Murdoch Children's Research Institute
2023
Sydney Children's Hospital
2018-2023
Women's and Children's Hospital
2023
Recent advances in the generation of cardiomyocytes (CMs) from human pluripotent stem cells (hPSCs), conjunction with promising outcomes preclinical and clinical studies, have raised new hopes for cardiac cell therapy. We report development a scalable, robust, integrated differentiation platform large-scale production hPSC-CM aggregates stirred suspension bioreactor as single-unit operation. Precise modulation process by small molecule activation WNT signaling, followed inactivation...
Circulating neutrophil phenotype and function are altered during neutrophilia associated with acute inflammatory states, however, the contribution of bone marrow release to these changes has been difficult quantify in humans. Accelerated neutrophils, potentially distinct attributes, from their dilution within circulating pool may produce apparent changes. Unfortunately selective analysis newly emergent neutrophils is given morphologic similarity those already circulation coincident effect...
These first Australian National Standards of Care for Childhood-onset Heart Disease (CoHD Standards) have been developed to inform the healthcare requirements CoHD services and enable all patients, families carers impacted by (paediatric adult congenital heart disease [ACHD]) live their best healthiest lives. The are designed provide clarity certainty required deliver excellent, comprehensive, inclusive, equitable care across Australia carers, offer an iterative roadmap future these...
Abstract Membrane-activated complex 1 (Mac-1; CD11b/CD18) is a β2 integrin implicated in the pathophysiology of neutrophil-mediated tissue injury whose functional capacity determined by stimulus-induced conformational activation rather than up-regulation. Mac-1 up-regulation and activation, together with shedding L-selectin, are reported after vitro neutrophil activation. However, their regulation on circulating human neutrophils during acute inflammation unclear. Using flow cytometry, we...
Early clinical outcomes data for adjunctive systemic sirolimus therapy (SST) moderate to severe pediatric pulmonary vein stenosis (PVS) are promising but limited. The authors aimed characterize a cohort of patients treated with SST determine if was associated reduction in frequency PVS interventions. Medical records 45 ≥1 month from 2015 2022 were retrospectively reviewed. intervention rates pre-SST and on-SST compared using generalized Poisson mixed models, accounting paired intervals...
Acute inflammatory stimuli rapidly mobilize neutrophils from the bone marrow by shortening postmitotic maturation time and releasing younger neutrophils; however, kinetics of this change in remains unknown. We propose a kinetic model that examines rate neutrophil average age at exit during active mobilization to quantify response use examine temporal profile late phenotypic maturation. Total CD10(-)/CD16(low) circulating were quantified cardiac surgery patients extracorporeal circulation...
Previous studies investigating risk factors associated with reoperation or mortality after repair of complete atrioventricular septal defect (CAVSD) often have not included sizeable cohorts undergoing modified single-patch repair. Both double patch and techniques been widely used in Australia since the 1990s. Using a large multi-institutional cohort, we aimed to identify following CAVSD repair.Between January 1990 December 2015, total 829 patients underwent biventricular surgical at 4...
When evaluated prospectively, acute brain injury is reported in up to 75% of neonates undergoing cardiopulmonary bypass (CPB), predominantly white matter rather than stroke. This study investigates the incidence stroke (focal infarct and/or haemorrhage) detected by neuroimaging contemporary clinical practice, whereby magnetic resonance imaging/computed tomography routinely occurs response events, comparing those Norwood procedure with other neonatal procedures involving CPB, and defines...
Background Successful anatomic repair of congenitally corrected transposition the great arteries achieves excellent outcomes. Several centers report long-term survival with Fontan pathway as well. We have selectively applied both approaches depending on individual patient morphology, preferred but utilizing when high technical complexity or operative risk is anticipated. Methods Hospital records over an 18-year period (1998–2016) were reviewed to identify patients who underwent surgical...
We sought to evaluate the outcomes following right ventricle pulmonary artery (RV-PA) conduit placement in pediatric patients, excluding those with a RV-PA for Ross procedure which is associated improved durability, partly related its orthotopic position.Outcomes 119 patients who underwent at single institution from January 2004 December 2016 were reviewed. Primary outcome measures reintervention-free survival (RFS) and overall survival. Survival analyses performed using Kaplan-Meier method,...