A5101709888- Genetics, Bioinformatics, and Biomedical Research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Connexins and lens biology
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Soil and Unsaturated Flow
- Genetic factors in colorectal cancer
- Geothermal Energy Systems and Applications
- Ubiquitin and proteasome pathways
- Colorectal Cancer Screening and Detection
- Nuclear Receptors and Signaling
- Bioinformatics and Genomic Networks
- Climate change and permafrost
- Nutrition, Genetics, and Disease
- Heat shock proteins research
- Neurological Disease Mechanisms and Treatments
- Intraocular Surgery and Lenses
- Reproductive Biology and Fertility
- Estrogen and related hormone effects
- Hepatitis B Virus Studies
- Cell death mechanisms and regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Wound Healing and Treatments
- Corneal surgery and disorders
Nanjing Drum Tower Hospital
2025
Beijing University of Technology
2023-2024
Sun Yat-sen University
2020-2024
Army Medical University
2020-2024
Daping Hospital
2023-2024
Shandong University
2009-2024
Tianjin University of Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Shandong Provincial Hospital
2024
First Affiliated Hospital of Jinan University
2024
The methyltransferase EZH2 plays an important role in regulating chromatin conformation and gene transcription. Phosphorylation of at S21 by AKT kinase suppresses its function. However, protein phosphatases responsible for the dephosphorylation EZH2-S21 remain elusive. Here, it is demonstrated that highly expressed ocular lens, AKT-EZH2 axis TGFβ-induced epithelial-mesenchymal transition (EMT). More importantly, identified MYPT1/PP1 dephosphorylates thus modulates functions. MYPT1 knockout...
Background The novel International Association for the Study of Lung Cancer (IASLC) grading system suggests that poorly differentiated invasive pulmonary adenocarcinoma (IPA) has a worse prognosis. Therefore, prediction IPA before treatment can provide an essential reference therapeutic modality and personalized follow-up strategy. This study intended to train nomogram based on CT intratumoral peritumoral radiomics features combined with clinical semantic features, which predicted was tested...
Acute lung injury (ALI) is a respiratory disorder characterized by severe inflammation of the alveoli and parenchyma. Tetramethylpyrazine (TMP), main active compound in Ligusticum chuanxiong Hort (LC), can protect against lipopolysaccharide (LPS)-induced ALI. Our study aimed to investigate how TMP protects endothelial cell barrier pulmonary capillaries. We administered intraperitoneally at different doses found that acute mice was improved, but not dose-dependent manner. toxicity tested...
Skin regeneration is a challenging issue worldwide. Increasing research has highlighted the role of immune cells in healing and underlying regulatory mechanism. The purpose this study was to identify hotspots trends skin inflammation through bibliometrics provide insights into future development fundamental disease treatment. Publications were collected from Web Science Core Collection on March 1, 2022. Articles reviews published English January 1999, December 31, 2022, selected, statistical...
: Interleukin-6 (IL-6) has an important role during prostate cancer progression and IL-6 levels in the serum of patients with hormone refractory metastatic are significantly increased compared those sensitive localized cancer. The G>C polymorphism at position -174 promoter gene been associated differences transcription vitro protein vivo. We determined association progression.: examined risk advanced disease 95 different stages using tetra-primer polymerase chain reaction genotyping method.:...
Overexpression of peroxiredoxin 1 (Prx1) has been observed in numerous cancers including oral squamous cell carcinoma (OSCC). The precise molecular mechanism up-regulation Prx1 carcinogenesis, however, is still poorly understood. objective this study to investigate the relationship between and hypoxia, potential mechanism(s) OSCC line SCC15 xenograft model. We treated wild-type knockdown cells with transient hypoxia followed by reoxygenation. detected condition production reactive oxygen...
To explore risk factors for 1-year postoperative mortality and to identify its association with the Revised Cardiac Risk Index (RCRI). This was a retrospective cohort study involving 54,933 patients aged 18 years above who were surgically treated under general or regional anesthesia in tertiary hospital Singapore. Independent identified by univariate Cox regression analysis. The between RCRI assessed Kaplan-Meier estimator multivariate analysis further validated subgroup analyses stratified...
Abstract This paper considers the guidance issue for attackers against aircraft with active defense in a two-on-two engagement, which includes an attacker, protector, defender and target. A cooperative line-of-sight scheme prescribed performance input saturation is proposed utilising sliding mode control theories, guarantees that attacker able to capture target assistance of protector remaining on between order intercept defender. fixed-time function first-order anti-saturation auxiliary...
This study aimed to evaluate the cumulative live birth rate (cLBR) of progestin-primed ovarian stimulation (PPOS) protocol versus gonadotropin-releasing hormone antagonist (GnRH-ant) for in vitro fertilization (IVF) cycle infertile women with normal reserve (NOR). Infertile NOR who underwent their first IVF were enrolled an open-label randomized controlled trial. Patients randomly assigned 1:1 receive a freeze-all strategy delayed embryo transfer (PPOS group, n = 174) and fresh (GnRH-ant...
To evaluate the effects of high-dose dexamethasone (HD-DXM) on balance interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well IFN-gamma, IL-4 plasma levels platelet counts were determined 17 patients receiving DXM 40 mg/day for four consecutive days 24 healthy subjects. Using RT-PCR, mRNA expression IL-18BP, IL-4, T-box (T-bet) GATA-binding 3(GATA-3) studied all The vitro peripheral blood mononuclear cells (PBMCs) by...
Purpose: The pivotal role of microRNAs (miRNAs or miRs) has been proved in the pathogenesis retinoblastoma. miR-224-3p is demonstrated to be involved several tumors. However, underlying mechanism retinoblastoma yet investigated. Therefore, this study was designed identify regulation human Methods: expression pattern and large tumor suppressor 2 (LATS2) measured by reverse transcription quantitative polymerase chain reaction. Afterward, interaction between LATS2 identified using a dual...
Abstract Anovulation is the main feature of infertile women with polycystic ovary syndrome (PCOS), and there very limited understanding role plasma exosomes miRNAs in it. To identify effect PCOS patients' exosomal miRNAs, we isolated patients normal injected into 8‐week‐old ICR female mice via tail vein. The changes estrus cycle, serum hormone levels, ovarian morphology were observed. KGN cells cultured transfected mimics inhibitors differentially expressed (miR‐18a‐3p, miR‐20b‐5p,...
Breast cancer is the most common in women and one of leading causes death worldwide. Ferroptosis, a promising mechanism killing cells, has become research hotspot therapy. Simvastatin (SIM), as potential new anti-breast drug, been shown to cause ferroptosis cells inhibit breast metastasis recurrence. The purpose this study develop novel strategy boosting ferroptotic cascade for synergistic
Photocatalytic efficiency is closely correlated to visible‐light absorption ability, electron transfer and catalytic center activity of photocatalysts, nevertheless, the concurrent management these factors improve photocatalytic remains underexplored. Herein, we proposed a sensitizer/catalyst dual regulation strategy on polyoxometalate@Metal−Organic Framework (POM@MOF) molecular platform construct highly efficient photocatalysts. Impressively, Ni‐Sb9@UiO‐Ir‐C6, obtained by coupling strong...