A5085734895- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Bone Metabolism and Diseases
- Alzheimer's disease research and treatments
- Selenium in Biological Systems
- Medicinal Plant Pharmacodynamics Research
- Medicinal Plants and Bioactive Compounds
- Carbon and Quantum Dots Applications
- Bone health and treatments
- Bioinformatics and Genomic Networks
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Machine Learning in Bioinformatics
- Cell Adhesion Molecules Research
- Organoselenium and organotellurium chemistry
- Trace Elements in Health
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Arsenic contamination and mitigation
Shandong First Medical University
2023-2025
Affiliated Hospital of Taishan Medical University
2024-2025
Toronto Western Hospital
1989
University of Toronto
1989
Mount Sinai Hospital
1989
New York University Langone Orthopedic Hospital
1987
University Medical Center
1987
United Biomedical (United States)
1986
Complementary DNA (cDNA) clones encoding beta chains of the DR and DQ regions alpha region were isolated sequenced from four homozygous DR4 cell lines different HLA-D types: GM3103(Dw4), FS(Dw10), BIN(Dw14), KT3(Dw15). When compared with each other a previously published sequence (Dw13 line), variability 1 gene products is generally restricted to around amino acid position 70, an additional polymorphism at 86. Many these differences, including unusual substitution 57 in Japanese line...
While nonmutated germline variable region (V) genes have been found to encode heavy or light chains of various human autoantibodies, the use V by both a given autoantibody has not documented. Recently, we reported that chain gene (designated Humha346) Kim4.6 anti-DNA antibody is identical VH gene, 1.9III. To investigate whether this was entirely encoded, searched for counterpart lambda segment Humla146) and isolated I designated Humlv117, which Humla146. Together with sequence identity...
ABSTRACT Amyloid‐β (Aβ) deposition was an important pathomechanisms of Alzheimer's disease (AD). Aβ generation highly regulated by beta‐site amyloid precursor protein cleaving enzyme 1 (BACE1), which is a prime drug target for AD therapy. The silence BACE1 function to slow down production accepted as effective strategy combating AD. Herein, interfering RNA, metallothionein (MT) and ruthenium complexes ([Ru(bpy) 2 dppz] 2+ ) were all loaded in Prussian blue nanoparticles (PRM‐siRNA)....
Osteoporosis (OP) is a systemic bone disease with loss of mass and destruction the microscopic structure. Many antiosteoporosis drugs have been used for OP therapy, but therapeutic efficiency remains limited. Therefore, there an urgent need to develop new treatment. Selenium (Se) one kind essential trace element humans displays pivotal roles in maintaining homeostasis. However, modulation Se are greatly affected by its chemical forms. Herein, containing protein derived from Se-enriched...
Abstract Two major DR7 haplotypes have been defined on the basis of serologic typing: those that type as DQw2 and others DQw3. In order to define molecular for these differences we isolated sequenced DQ alpha, DR beta I, cDNA clones from both representative haplotypes. These studies reveal although alpha I genes are identical, very different. data suggest two result a recombinational event occurred between genes. addition, they emphasize role recombination in generating "hybrid" HLA-DQ heterodimers.