A5100776742- COVID-19 diagnosis using AI
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Long-Term Effects of COVID-19
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Ear and Head Tumors
- Colorectal and Anal Carcinomas
- Head and Neck Surgical Oncology
- Colorectal Cancer Surgical Treatments
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Alzheimer's disease research and treatments
- RNA modifications and cancer
- Natural Language Processing Techniques
- Topic Modeling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ultrasound in Clinical Applications
- Medicinal Plant Pharmacodynamics Research
- Head and Neck Cancer Studies
- Selenium in Biological Systems
Anhui Agricultural University
2022-2025
Peking University
2024
Shaanxi Provincial People's Hospital
2024
First Affiliated Hospital of Henan University
2024
Qilu Hospital of Shandong University
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Shandong University
2023
Liaoning Cancer Hospital & Institute
2022
China Medical University
2022
Cancer Hospital of Chinese Academy of Medical Sciences
2021
Chemoresistance is one of the major causes therapeutic failure and poor prognosis for breast cancer patients, especially triple-negative patients. However, underlying mechanism remains elusive. Here, we identified novel functional roles heat shock protein beta-1 (HSPB1), regulating chemoresistance ferroptotic cell death in cancer. Based on TCGA GEO databases, HSPB1 expression was upregulated tissues associated with which considered an independent prognostic factor Functional assays revealed...
To delineate the evolution of CT findings in patients with mild COVID-19 pneumonia.CT images and medical records 88 confirmed pneumonia, a baseline CT, at least one follow-up were retrospectively reviewed. features including lobar distribution presence ground glass opacities (GGO), consolidation, linear analyzed on per-patient basis during each five time intervals spanning 3 weeks after disease onset. Total severity scores calculated.Of patients, 85.2% had travel history to Wuhan or known...
To identify the initial chest computed tomography (CT) findings and clinical characteristics associated with course of coronavirus disease 2019 (COVID-19) pneumonia. Baseline CT scans laboratory data 72 patients admitted COVID-19 pneumonia (39 men, 46.2 ± 15.9 years) were retrospectively analyzed. including lobar distribution, presence ground glass opacities, consolidation, linear lung severity score evaluated. The outcome event was recovery hospital discharge. time from symptom onset to...
Background As a pandemic, most-common pattern resembled organizing pneumonia (OP) has been identified by CT findings in novel coronavirus disease (COVID-19). We aimed to delineate the evolution of and outcome OP COVID-19. Materials methods 106 COVID-19 patients with based on were retrospectively included categorized into non-severe (mild/common) severe (severe/critical) groups. features including lobar distribution, presence ground glass opacities (GGO), consolidation, linear total severity...
Alzheimer's disease (AD) as a common neurodegenerative showed progressive cognitive dysfunction and behavioral impairment. Currently, the deposition of amyloid β-protein (Aβ) remains main pathomechanism. However, preventing neuronal death induced by Aβ elusive, no effective strategy in clinic was found to combat AD. Herein, multifunctional double selenium nanosphere (CLNDSe) designed prepared, A
In this study, the hands and feet of 15,384 undergraduate postgraduate students in 3 colleges Beijing were examined for presence cutaneous warts at college-entry, those diagnosed with followed up 2-3 years later. We identified totally 215 (1.4%; 95% CI, 1.2-1.6%) warts. The prevalence was significantly higher male than female (2.0% vs. 0.9%, P < 0.0001). Of patients, 66.9% 62.1% had only one wart 98.3% 93.2% <1 cm diameter, on feet, respectively. 130 patients a follow-up visit, 78 did not...
ABSTRACT Amyloid‐β (Aβ) deposition was an important pathomechanisms of Alzheimer's disease (AD). Aβ generation highly regulated by beta‐site amyloid precursor protein cleaving enzyme 1 (BACE1), which is a prime drug target for AD therapy. The silence BACE1 function to slow down production accepted as effective strategy combating AD. Herein, interfering RNA, metallothionein (MT) and ruthenium complexes ([Ru(bpy) 2 dppz] 2+ ) were all loaded in Prussian blue nanoparticles (PRM‐siRNA)....
Breast cancer is one of the most lethal malignancies among women; however, underlying molecular mechanism involved in progression and metastasis breast remains unclear. Numerous studies have confirmed that long noncoding RNAs are abnormally expressed play crucial roles cell proliferation metastasis. In study, we evaluated functional role detailed DGUOK-AS1 knockdown suppressed proliferation, migration, invasion cells vitro vivo. Mechanistically, miR-204-5p was identified as an inhibitory...
SARS-CoV-2 Omicron sublineages escape most preclinical/clinical neutralizing antibodies in development, suggesting that previously employed antibody screening strategies are not well suited to counteract the rapid mutation of SARS-CoV-2. Therefore, there is an urgent need screen better broad-spectrum antibody. In this study, a comprehensive approach design inhibitors against both SARS-CoV-1 and by leveraging structural diversity nanobodies proposed. This includes de novo fully human nanobody...
This study was intended to investigate the effects of icariin on healing tooth extraction sites under systemic administration zoledronic and dexamethasone.Thirty female rats underwent bilateral ovariectomy were randomly assigned 5 groups: SS group received a weekly injection saline, while ZD, ZD + LICA, MICA, HICA groups with dexamethasone for 8 weeks. One week later, mandibular first molars extracted in all groups. Then, 30, 60, 120 mg/kg intragastrically given daily 10 weeks, saline group....
Abstract Background The aim of this study is to compare the effects icariin and teriparatide on treatment medication‐related osteonecrosis jaw (MRONJ) using a rat model. Methods Fifty rats undergoing ovariectomy were randomly assigned control group (n = 10) MRONJ model 40). Zoledronic acid (0.2 mg/kg) dexamethasone (2 injected into in for 8 weeks while saline was applied group, then all underwent tooth extraction bone defect. Eight later, diagnosed with 33) distributed 11), untreated 11)...
As the capabilities of large multimodal models (LMMs) continue to advance, evaluating performance LMMs emerges as an increasing need. Additionally, there is even larger gap in advanced knowledge and reasoning abilities non-English contexts such Chinese. We introduce CMMMU, a new Chinese Massive Multi-discipline Multimodal Understanding benchmark designed evaluate on tasks demanding college-level subject deliberate context. CMMMU inspired by strictly follows annotation analysis pattern MMMU....
Amyloid-β (Aβ) deposition was an important pathomechanisms of Alzheimer’s disease (AD). Aβ generation highly regulated by beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), which is a prime drug target for AD therapy. Silence BACE1 function to slow down production accepted as effective strategy combating AD. Herein, interfering RNA, metallothionein (MT) and ruthenium complexes ([Ru(bpy)2dppz]2+) were all loaded in prussian blue nanoparticles (PRM-siRNA). PRM-siRNA under...
Background Hemorrhagic fever with renal syndrome (HFRS) is a natural epidemic disease that can be caused by the Hantaan virus (HTNV). Malaria plasmodium and transmitted mosquito bite. The similar manifestations shared these disorders pose challenge for clinicians in differential diagnosis, particular, coupled false-positive serological test. Case presentation A 46-year-old man was admitted chills over 10 days suspected of being co-infected HFRS malaria due to history travel malaria-endemic...
Abstract Objective As a pandemic, most-common pattern resembled organizing pneumonia (OP) has been identified by CT findings in novel coronavirus disease (COVID-19). We aimed to delineate the evolution of and outcome OP COVID-19. Materials Methods 106 COVID-19 patients with based on were retrospectively included categorized into non-severe (mild/common) severe (severe/critical) groups. features including lobar distribution, presence ground glass opacities (GGO), consolidation, linear total...
Abstract Objectives To evaluate the frequency and time course of RHS on CT in patient with COVID-19 pneumonia. Materials methods A total 147 patients pneumonia were divided into mild, moderate, severe critical categories. The number, location, shape, wall appearance analyzed. Other parenchymal abnormalities include GGO, consolidation linear opacity also recorded. Results was observed 37 (25.2%) it more common moderate disease than or (31.3% vs. 13.0%, P = 0.019). Time from symptom onset to 9...
Primary squamous cell carcinoma of parotid gland (parotid SCC) is a high malignant histologic subtype cancers with aggressive clinical presentation. However, the features and survival benefit postoperative radiotherapy (PORT) for primary SCC are not well known.A retrospective population-based study was performed to identify role PORT in patients diagnosed between 1975 2016 from SEER database. A prognostic risk model established based on patient features, including age, tumor stage, node...
The objectives of this study were to analyze the difference between preoperative radiological and postoperative pathological stages colorectal cancer (CRC) explore feasibility elastic lamina invasion (ELI) as a prognostic marker for patients with stage III colon cancer.A total 105 consecutive underwent radical surgery (R0 resection) at Cancer Hospital China Medical University January 2015 December 2017. Clinicopathological features, including staining, analyzed significance in who met...
Triple-negative breast cancer (TNBC) is a subtype of with higher aggressiveness and poorer outcomes. Recently, long non-coding RNAs (lncRNAs) have become the crucial gene regulators in progression human cancers. However, function underlying mechanisms lncRNAs TNBC remains unclear.Based on public databases bioinformatics analyses, low expression lncRNA MIDEAS-AS1 tissues was detected further validated cohort tissues. The effects proliferation, migration, invasion were determined by vitro vivo...
BackgroundCoinfection poses a persistent threat to global public health due its severe effect on individual-level infection risk and disease outcome. Coinfection of SARS-CoV2 with one or more pathogens has been documented. Nevertheless, this virus co-infected the Hantaan (HTNV) is rarely reported.Case summaryHere, we presented three cases HTNV complicated infection. Not only conditions including general clinical manifestations, immune inflammation parameters fluctuation in single can be...