A5103158452- Cell death mechanisms and regulation
- Immune Response and Inflammation
- Asymmetric Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Histone Deacetylase Inhibitors Research
- Bone Metabolism and Diseases
- Asymmetric Hydrogenation and Catalysis
- Protein Degradation and Inhibitors
- Industrial Gas Emission Control
- Carbon dioxide utilization in catalysis
- Gas Sensing Nanomaterials and Sensors
- Catalytic C–H Functionalization Methods
- Fluorine in Organic Chemistry
- Catalytic Processes in Materials Science
- Biomarkers in Disease Mechanisms
- HIV/AIDS drug development and treatment
- interferon and immune responses
- Organic Chemistry Cycloaddition Reactions
- Click Chemistry and Applications
- Medicinal Plant Pharmacodynamics Research
- Oral Health Pathology and Treatment
- Synthetic Organic Chemistry Methods
- Catalytic Cross-Coupling Reactions
- Advanced Sensor and Energy Harvesting Materials
- Multiple Myeloma Research and Treatments
Sichuan University
2014-2024
Zhejiang University
2023
Stomatology Hospital
2023
State Key Laboratory of Biotherapy
2017-2020
State Key Laboratory of Oral Diseases
2017
Chengdu Institute of Biology
2004
Abstract Reductive carboxylation of organo (pseudo)halides with CO 2 is a powerful method to provide carboxylic acids quickly. Notably, the catalytic reductive carbo‐carboxylation unsaturated hydrocarbons via fixation highly challenging but desirable approach for structurally diverse acids. There are only few reports and no examples alkenes transition metal catalysis. We report first asymmetric nickel A variety aryl (pseudo)halides, such as bromides, triflates inert chlorides particular...
Abstract Reliable interfacial bonding is an essential guarantee that flexible electronics can output realistic signals, especially for underwater scenes. However, conventional self‐adhesive materials usually suffer from adhesion failure, conflict between and cohesion, as well adverse effects of isotropous residue, greatly limiting their applications in electronics. Herein, a Janus hydrophobic structural gel (HSG) with asymmetric fabricated by “grafting one twig on another” approach (in situ...
Upon the basis of The Cancer Genome Atlas (TCGA) data set, we identified that several autophagy-related proteins such as AMP-activated protein kinase (AMPK) were remarkably downregulated in breast cancer. Combined with coimmunoprecipitation assay, demonstrated BRD4 might interact AMPK. After analyses pharmacophore and WPF interaction optimization, designed a small-molecule inhibitor BRD4, 9f (FL-411) which was validated by cocrystal structure BD1 BRD4. Subsequently, discovered to induce...
[reaction: see text] Hetero-Diels-Alder reactions of Brassard diene with aromatic aldehydes were carried out smoothly in the presence titanium(IV) tridentate Schiff base complexes to give corresponding chiral delta-lactones high enantioselectivities (up 99% ee) under mild conditions.
Abstract Objective To explore the mechanism of receptor‐interacting protein 1 (RIP1)‐mediated necroptosis during periodontitis progression. Background RIP3 and mixed lineage kinase domain‐like (MLKL) have been detected to be upregulated in models. Because RIP1 is involved necroptosis, it might also play a role progression periodontitis. Methods An experimental model BALB/c mice was established by inducing oral bacterial infection. Western blotting immunofluorescence analyses were used detect...
A palladium-catalyzed asymmetric allylation of N-fluorenyl trifluoromethyl imine with allylic acetates is disclosed. This method provides scalable and efficient access to polysubstituted chiral α-trifluoromethyl amines bearing two adjacent stereocenters one allyl group in high yields excellent regio-, diastereo-, enantioselectivity. Importantly, this also a powerful strategy for the synthesis both regioisomeric products regioselectivity controlled by catalysts optically active substrates.
Abstract We have found that readily available N ‐alkyl hydroxylamines are effective reagents for the amination of organoboronic acids in presence trichloroacetonitrile. This reaction proceeds rapidly at room temperature and absence added metal or base, it tolerates a remarkable range functional groups, can be used late‐stage assembly two complex units.
Abstract Background Occlusal trauma can aggravate periodontitis, but the mechanism remains unclear. Yes‐associated protein (YAP), a mechanical stressor protein, may play an important role in this process. Methods Western blot and quantitative real‐time polymerase chain reaction (qRT‐PCR) were applied to detect expression of YAP inflammatory factors patients with periodontitis accompanied or without occlusal trauma. Through local administration Porphyromonas gingivalis composite resin bonding...
To explore the role of necroptosis in apical periodontitis (AP), this study investigated a Fusobacterium nucleatum (Fn)-induced AP model Balb/c mice and explored related intracellular signalling pathways L929 cells affected by Fn.For vivo experiments, expression receptor-interacting protein kinase-3 (RIP3) was inhibited using an adeno-associated virus then established injecting Fn into root canal first mandibular molars. Bone loss number osteoclasts were measured via micro-computed...
Abstract Reductive carboxylation of organo (pseudo)halides with CO 2 is a powerful method to provide carboxylic acids quickly. Notably, the catalytic reductive carbo‐carboxylation unsaturated hydrocarbons via fixation highly challenging but desirable approach for structurally diverse acids. There are only few reports and no examples alkenes transition metal catalysis. We report first asymmetric nickel A variety aryl (pseudo)halides, such as bromides, triflates inert chlorides particular...
This study was intended to investigate the effects of icariin on healing tooth extraction sites under systemic administration zoledronic and dexamethasone.Thirty female rats underwent bilateral ovariectomy were randomly assigned 5 groups: SS group received a weekly injection saline, while ZD, ZD + LICA, MICA, HICA groups with dexamethasone for 8 weeks. One week later, mandibular first molars extracted in all groups. Then, 30, 60, 120 mg/kg intragastrically given daily 10 weeks, saline group....
Rheumatoid arthritis (RA) and periodontitis share many epidemiological pathological features, with emerging studies reporting a relationship between the two diseases. Recently, RA have been associated autophagy. In present study, we investigated effects of cathepsin K (CtsK) inhibition on in mouse model its immunological function affecting To topically inhibit CtsK animal model, adeno-associated virus (AAV) transfection was performed periodontal knee joint regions. Transfection small...
Abstract Reported is the asymmetric propargylic substitution (APS) reaction of 5 H ‐thiazol‐4‐ones using a Cu/Zn dual metal catalytic system and APS ‐oxazol‐4‐ones Cu/Ti system. These reactions furnish functional‐group‐rich, terminal‐alkyne‐containing products with two vicinal stereocenters in high yields good to excellent diastereo‐ enantioselectivities. This study demonstrates use systems as viable approach improve selectivity profiles copper‐catalyzed reactions.
The removal of high concentration flue gas sulfur dioxide (SO2) using manganese carbonate ore desulfurization (MCO-FGD) is a promising route that combines economic benefits and pollution control. However, the problems intermediate oxidation by-product control have plagued industrial application MCO-FGD technique for long time. Based on fact there symbiosis iron in natural ore, this study, small amounts Fe(III) MnO2 were introduced into reaction system to enhance SO2 SO4− suppress manganous...
To investigate the involvement and role of receptor-interacting protein 3 (RIP3)-mediated necroptosis in periodontitis.
To explore the role of Rgs10-associated nuclear factor (NF)-κB signalling pathway in periodontitis with rheumatoid arthritis.Porphyromonas gingivalis and collagen were locally applied to mice establish vivo arthritis models, respectively. Both agents administered together comorbid group. All models treated adeno-associated virus-green fluorescent protein (AAV-GFP) or virus small hairpin Rgs10 (AAV-sh-Rgs10). In expression inflammatory cytokines was analysed, along exploration NF-κB...
Abstract Azomethine ylides, generated in situ from oxindoles and aldehydes undergo 1,3‐dipolar cycloaddition with nitroalkanes.
Abstract Title compounds are efficiently synthesized through a cascade Michael/cyclization reaction.