A5008815302- Cancer Research and Treatments
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Viral Infectious Diseases and Gene Expression in Insects
- Lung Cancer Treatments and Mutations
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Viral Infections and Immunology Research
- Cancer, Hypoxia, and Metabolism
- Viral gastroenteritis research and epidemiology
- Genetics, Aging, and Longevity in Model Organisms
- Chemokine receptors and signaling
- Heat shock proteins research
- Signaling Pathways in Disease
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Veterinary Oncology Research
- RNA Research and Splicing
- Tumors and Oncological Cases
- RNA Interference and Gene Delivery
- Molecular Biology Techniques and Applications
- Cancer therapeutics and mechanisms
Engelhardt Institute of Molecular Biology
2007-2024
Ministry of Health of the Russian Federation
2023
Russian Cancer Research Center NN Blokhin
2005-2018
"National Medical Research Center for Rehabilitation and Balneology" of the Ministry of Health of the Russian Federation
2018
Cleveland Clinic
2005-2012
Russian Academy of Sciences
1998-2008
Identification of unique features cancer cells is important for defining specific and efficient therapeutic targets. Mutant p53 present in nearly half all cases, forming a promising target pharmacological reactivation. In addition to being defective the tumor-suppressor function, mutant contributes malignancy by blocking family member p73. Here, we describe small-molecule RETRA that activates set p53-regulated genes specifically suppresses p53-bearing tumor vitro mouse xenografts. Although...
ABSTRACT Inactivation of p53 tumor-suppressor leads to genetic instability and, in particular, accumulation cells with abnormal numbers chromosomes. In order better define the role function maintaining genome integrity we investigated involvement control proliferation micronucleated resulting from chromosome segregation. Using cell lines expressing temperature-sensitive (ts) or containing suppressor element (p53-GSE) showed that inhibition increases frequency micronuclei. Immunofluorescence...
BACKGROUND: Canine mastocytomas (mast cell tumors) represent a common malignancy among many dog breeds. A typical treatment strategy for canine includes surgery, chemo- and radiotherapy, although in cases the therapy fails disease progression resumes. New approaches are needed. AIMS: The goal of this pilot study was to examine safety efficacy oncolytic Sendai virus administered patients with cutaneous or subcutaneous mastocytomas. MATERIALS AND METHODS: Six patients, variable grades stages...
During growth in the host, tumor cells are subjected to stresses of innate and adaptive immunity (immunoediting), which provoke epigenetic changes increase resistance these immune responses. Our recent studies methylcholanthrene-induced fibrosarcomas have indicated appearance rapid variants deficient producing T cell chemoattractant chemokine CXCL9/Mig, an important component antitumor immunity. In current report, we demonstrate that highly tumorigenic Mig-deficient arise both cutaneous...
In mammals a small family of genes called Sestrins play important roles in the maintenance metabolic and redox homeostasis, suggesting that may positively affect lifespan counteract age-related functional decline. The nematode genome contains single cSesn gene makes Caenorhabditis elegans an excellent model for studying functions sestrin family. We describe phenotypic differences worms have compromised expression gene. By comparing three different cSesn-deficient modes with wild-type C....
INTRODUCTION. Developing novel medicines based on non-pathogenic enterovirus strains exhibiting oncotropic and oncolytic properties represents an up-to-date safe approach to complex cancer treatment postoperative metastasis prevention. Safety pharmacology studies are a necessary step in the preclinical development of medicinal products. AIM. The study aimed investigate single repeated-dose general toxicity, local tolerance, safety pharmacology, pyrogenicity products LEV4, LEV7, LEV8, LEV14,...