A5116653527- Nutrition and Health in Aging
- Extracellular vesicles in disease
- Kidney Stones and Urolithiasis Treatments
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Cardiovascular Effects of Exercise
- Histone Deacetylase Inhibitors Research
- Organometallic Compounds Synthesis and Characterization
- Textile materials and evaluations
- Pediatric Urology and Nephrology Studies
- Kruppel-like factors research
- Ureteral procedures and complications
- Advanced Statistical Methods and Models
- Neurofibromatosis and Schwannoma Cases
- Muscle and Compartmental Disorders
- Stroke Rehabilitation and Recovery
- Virus-based gene therapy research
- Maritime Ports and Logistics
- Vehicle Routing Optimization Methods
- Advanced Statistical Process Monitoring
- Cardiac Health and Mental Health
- Computational Drug Discovery Methods
- Autophagy in Disease and Therapy
Fosun Pharma (China)
2023-2025
Chengdu University of Traditional Chinese Medicine
2022-2025
Sichuan University
2023-2025
Linköping University
2023-2025
Sichuan Tourism University
2024-2025
West China Hospital of Sichuan University
2025
Minzu University of China
2025
Xiangya Hospital Central South University
2023-2024
Central South University
2023-2024
Lianyungang Oriental Hospital
2024
Retrograde intrarenal surgery (RIRS) is the main treatments for upper urinary tract stones. The Ureteral Access Sheath (UAS) serves as a supplementary tool, facilitating direct kidney access during RIRS. High quality of evidence comparing tip bendable suction ureteral sheath (S-UAS) with traditional UAS in RIRS treatment renal and stones lacking. purpose study to compare efficacy safety S-UAS or ≤30 mm.
Abstract Recent technological advancements have vastly improved access to high-throughput biological instrumentation, sparking an unparalleled surge in omics data generation. The implementation of artificial intelligence techniques is revolutionizing interpretation. BMC Methods Collection "Artificial for analysis" will feature novel approaches leveraging multi-omics accelerate discoveries personalized medicine, disease diagnostics, drug development, and pathway elucidation.
Targeting macrophages to regulate the immune microenvironment is a new strategy for bone regeneration with nano-drugs. Nano-drugs have achieved surprising anti-inflammatory and bone-regenerative effects, however, their underlying mechanisms in remain be clarified. Macrophage polarization, immunomodulation, osteogenesis are governed by autophagy. Rapamycin, an autophagy inducer, has shown promising results regeneration, but high dose-mediated cytotoxicity low bioavailability hinder its...
Difficult-to-heal wounds management accounts for about 4% of healthcare costs, highlighting the need innovative solutions. Extracellular signals drive cell proliferation during tissue regeneration, while epigenetic mechanisms regulate stem homeostasis, differentiation, and skin repair. Exploring regulation in adipose-derived cells (ADSCs) holds promise improving injury treatments. We investigated effects histone deacetylase inhibitor (SAHA) on ADSCs to better understand its cellular...
Epidemiological evidence on the relationship between exposure to volatile organic compounds (VOCs), both single and mixed, serum lipid levels is limited, their remains unclear. Our study aimed investigate associations of VOCs with in US adult population.The examined association 16 VOC (2-methylhippuric acid, 3- 4-methylhippuric N-acetyl-S-(2-carbamoylethyl)-L-cysteine, N-acetyl-S-(N-methylcarbamoyl)-L-cysteine, 2-aminothiazoline-4-carboxylic N-acetyl-S-(benzyl)-L-cysteine,...
Frailty is a common geriatric syndrome worldwide, and its early identification intervention have important clinical significance. Resistance training has been recommended as an efficient means to combat loss of muscle strength mass; however, it often not prioritized option for older adults. Tai chi well-known traditional Chinese exercise that beneficial impact on physical performance, balance ability, metabolism, immune function. With the newly emerged concept muscle-immune homeostasis, this...
The genealogical and geographical distribution of a species offers insights into its evolutionary narrative, encompassing population dispersion, migration, adaptation, speciation—key aspects for comprehending the genesis sustenance biodiversity. Using three mitochondrial genes on 115 samples, this study examined phylogeographic structure, phylogenetic divergence, environmental evolution viviparous multiocellated racerunner (Eremias multiocellata) in Tarim Basin China. Our analyses revealed...
10044 Background: Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease characterized by multiple progressive tumor and non-tumor manifestations, with abnormal activating MAPK pathway. Plexiform neurofibromas (PN) presents in 20-50% of NF1 patients (pts) may cause serious complications. One MEK1/2 inhibitor was approved for pediatric pts NF1-related PN US, EU China, but therapeutic options remain limited. Luvometinib a highly potent selective anti-tumorigenic MEK1/2,...
Keloid is a major type of skin fibrotic disease, with one prominent feature extensive accumulation extracellular matrix (ECM) components, and another pain/itching, which closely related to the peripheral nervous system (PNS). However, molecular pathogenesis these two features still needs be further explored. In present study, we performed single-cell RNA sequencing (scRNA-seq) on clinical earlobe keloid samples adjacent normal constructed atlas 31,379 cells. All cells were clustered into 13...
We present an application of deep-learning convolutional neural network atomic surface structures using and Voronoi polyhedra-based neighbor information to predict adsorbate binding energies for the in catalysis.
Monitoring of frozen section diagnostic performance provides an important quality improvement measure.Surgical specimens involving a diagnosis over 3-year period were retrospectively reviewed. Glass slides reviewed on cases with discordance. Discordance and deferral rates calculated.Of 3,675 diagnoses included, 96 (2.7%) discordant the final diagnosis. Additionally, 114 (3.1%) deferred. The organ-specific discordance lowest in breast genitourinary highest for pancreas, lymph node,...
Abstract Background Protein–protein interactions are widespread in biological systems and play an important role cell biology. Since traditional laboratory-based methods have some drawbacks, such as time-consuming, money-consuming, etc., a large number of based on deep learning emerged. However, these do not take into account the long-distance dependency information between each two amino acids sequence. In addition, most existing models graph neural networks only aggregate first-order...
Pressure overload-induced pathological cardiac hypertrophy is an independent predecessor of heart failure (HF), which remains the leading cause worldwide mortality. However, current evidence on molecular determinants still inadequacy. This study aims to elucidate role and mechanisms Poly (ADP-ribose) polymerases 16 (PARP16) in pathogenesis hypertrophy.Gain loss function approaches were used demonstrate effects genetic overexpression or deletion PARP16 cardiomyocyte hypertrophic growth vitro....
Wisconsin Stone Quality of Life (WISQOL) has been designed specifically for patients with kidney stones. The present study aimed to develop the Chinese version WISQOL and reach its validation.The was translated into following a standard procedure. Kidney stone admitted surgical treatment were enrolled fulfilled both SF-36 on admission day at one month postoperatively. internal consistency, inter-domain correlation convergent validity analyzed.One hundred twenty-four 124 males 76 females...
Background: Malignant melanoma is an aggressive disease. Tunlametinib (HL-085) a potent, selective, and orally bioavailable MEK1/2 inhibitor. The objective of this study was to determine the pharmacokinetics (PK) tunlametinib its main metabolite M8 in patients with NRAS-mutant following single dose multiple doses phase I safety PK study. Methods: A multiple-center performed including dose-escalation dose-expansion phase. oral 0.5-18 mg twice daily assessed. Results: total 30 participants...