Rhythmic synchronization of neurons in the beta or gamma band occurs almost ubiquitously, and this has been linked to numerous nervous system functions. Many respective studies make implicit assumption that neuronal affects interactions. Indeed, when synchronize, their output spikes reach postsynaptic together, trigger coincidence detection mechanisms, therefore have an enhanced impact. There is ample experimental evidence demonstrating consequence synchronization, but beyond this,...

Abstract Behavioral studies using motor preparation paradigms have revealed that increased expectancy of a response signal shortens reaction times (RTs). Neurophysiological data suggest in such paradigms, not only RT but also neuronal activity the structures involved is modulated by behaviorally relevant events. Here, we directly tested whether modulates excitability corticospinal system used subsequent movement. We combined single- and paired-pulse transcranial magnetic stimulation (TMS)...

Many patients referred for PET suffer from anxiety, possibly affecting the workflow and patient experience. In addition, anxiety may affect image quality through uptake of ¹⁸F-FDG in muscles or brown adipose tissue (BAT).This study investigated effects a nonpharmacologic intervention—the use audiovisual imagery room—on false-positive (in BAT). <b>Methods:</b> A 2-stage was conducted on 101 patients. The cohort undergoing intervention included 51 first stage (<i>n</i> = 35)...

Flexible behavior requires the ability to delay a response until it is appropriate. This can be achieved by holding either sensory or motor representation online. Here we assess whether maintenance of material drives system different functional states, as indexed alterations corticospinal excitability. We used single-pulse TMS measure excitability evoked during period novel paradigm in which task contingencies, rather than explicit verbal instructions, induced participants use codes solve...

Preparation of the direction a forthcoming movement has particularly strong influence on both reaction times and neuronal activity in primate motor cortex. Here, we aimed to find direct neurophysiologic evidence for preparation humans. We used single-pulse transcranial magnetic stimulation (TMS) evoke isolated thumb-movements, which can be modulated experimentally, example by training or tasks. Sixteen healthy subjects performed brisk concentric voluntary thumb movements during time task...

A method to estimate the potential and current density distribution during transcranial DC stimulation (tDCS) is introduced. The volume conductor model consists of a realistic head (concerning shape as well conductivity), obtained from TI-, PD- DT-MR images. includes five compartments with different conductivities. For skull white matter compartments, conductivities are anisotropic. Using this model, potentials inside that generated by tDCS electrodes positioned on scalp were computed using...

To evaluate the diagnostic yield of magnetic cortical stimulation with triple technique (TST) to identify upper motor neuron (UMN) involvement in patients suspected having ALS.Fifty-nine were recruited undergo TST addition standard work-up for disease. combines transcranial cortex collision studies, which results a higher sensitivity detecting UMN involvement. Primary outcome was number abnormal possible ALS. The positivity rate converted needed test (NN-TST) one extra diagnosis ALS.Fifty...

Abstract Objective To validate a fully automated scoring algorithm for the Rey-Osterrieth Complex Figure Test (ROCFT) by comparing results of to human raters. Method The consisted cascade deep neural networks which were trained on rater scores extract 18 segments figure, and quantify patient’s performance. Algorithm compared six expert raters 303 drawings. We tested whether average correlation between all was equivalent inter-rater (with equality bound Δr &lt; .05). immediate delayed recall...

Emotionally arousing stimuli are perceived and remembered better than neutral stimuli. Under threat, this negativity bias is further increased. We investigated whether working memory (WM) load can attenuate incidental for emotional images. Two groups of participants performed the N-back task with two WM levels. In one group, we induced anxiety using a threat shock paradigm to increase attentional processing negative information. During performance incidentally briefly flashed distracter...

Objective: To collect evidence of validity for a selection digital tests on the Philips IntelliSpace Cognition (ISC) platform.Method: A total 200 healthy participants (age 50-80) completed both ISC battery and an analog version during separate visits. The included following screeners cognitive tests: Mini-Mental State Examination (2nd edition), Clock Drawing Test, Trail-Making Test (TMT), Rey Auditory Verbal Learning (RAVLT), Rey-Osterrieth Complex Figure (ROCFT), Letter Fluency, Star...

Clinical practice still relies heavily on traditional paper-and-pencil testing to assess a patient's cognitive functions. Digital technology has the potential be an efficient and powerful alternative, but for many of existing digital tests test batteries psychometric properties have not been properly established. We validated newly developed battery consisting digitized versions conventional neuropsychological tests. Two confirmatory factor analysis models were specified: model based theory...

This article provides the test-retest reliability and Reliable Change Indices (RCIs) of Philips IntelliSpace Cognition (ISC) platform, which contains digitized versions well-established neuropsychological tests.

The quality of an image produced by the Whole Slide Imaging (WSI) scanners is critical importance for using in clinical diagnosis. Therefore, it very important to monitor and ensure images. Since subjective assessments pathologists are time-consuming, expensive difficult reproduce, we propose a method objective assessment based on clinically relevant perceptual parameters: sharpness, contrast, brightness, uniform illumination color separation; derived from survey pathologists. We developed...

A bstract We evaluated a digital cognitive assessment platform, Philips IntelliSpace Cognition, in cross-sectional cohort of patients diagnosed with mild impairment (MCI). Performance on individual neuropsychological tests, domain scores, and Alzheimer’s disease (AD) specific composite scores MCI were compared cognitively normal adults (CN). The cohorts matched for age, sex, education. performance all but two tests was worse the group. After ranking domains by effect size, we found that...

BackgroundInformation transmission into the human nervous system is basis for a variety of prosthetic applications. Spinal cord stimulation (SCS) systems are widely available, have well documented safety record, can be implanted minimally invasively, and known to stimulate afferent pathways. Nonetheless, SCS devices not yet used computer-brain- interfacing applications.ObjectiveHere we aimed establish computer-to-brain communication via medical implants in group 20 individuals who had been...

Introduction: Demonstration of upper motor neuron (UMN) signs increases the accuracy diagnosis ALS, but validated tests are lacking. The triple stimulation technique (TST) combines transcranial magnetic cortex with nerve at intervals appropriatie for collision. In open studies TST has a high sensitivity.

Abstract Sensory substitution offers a promising approach to restore lost sensory functions. Here we show that spinal cord stimulation (SCS), typically used for chronic pain management, can potentially serve as novel auditory device. We recruited 13 patients undergoing SCS implantation and translated everyday sound samples into personalized patterns during their trial phase. In identification task—where chance-level performance was 33.3%—participants ( $$n=8$$ <mml:math...

We evaluated a digital cognitive assessment platform, Philips IntelliSpace Cognition, in case-control study of patients diagnosed with mild impairment (MCI) and cognitively normal (CN) older adults. Performance on individual neuropsychological tests, z -scores, Alzheimer's disease (AD)-specific composite scores was compared between the CN MCI groups. These groups were matched for age, sex, education. all but two tests worse group. After ranking by effect size, we found that memory score most...