A5066568865- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- 3D Printing in Biomedical Research
- Retinal Diseases and Treatments
- Cell Adhesion Molecules Research
- Corneal Surgery and Treatments
- Retinal and Macular Surgery
- Cellular Mechanics and Interactions
- Skin and Cellular Biology Research
- Corneal surgery and disorders
- Electrospun Nanofibers in Biomedical Applications
- Dermatological and Skeletal Disorders
- Connective tissue disorders research
- Autoimmune Bullous Skin Diseases
- Graphene and Nanomaterials Applications
- Ocular Surface and Contact Lens
- Retinal Imaging and Analysis
Tampere University
2018-2024
Forest Institute
2019
Charlottesville Medical Research
2019
John Wiley & Sons (United States)
2019
Wake Forest University
2019
Tampere University
2018
Abstract Background Human corneal endothelial cells lack regenerative capacity through cell division in vivo . Consequently, the case of trauma or dystrophy, only available treatment modality is tissue primary transplantation from cadaveric donor which faces a high global shortage. Our ultimate goal to use state-of-the-art 3D-bioprint technology for automated production human partial and full-thickness tissues using stem functional bioinks. In this study, we explore feasibility bioprinting...
Degeneration and/or dysfunction of retinal pigment epithelium (RPE) is generally detected as the formation intracellular and extracellular protein aggregates, called lipofuscin drusen, respectively, in patients with age-related macular degeneration (AMD), leading cause blindness elderly population. These clinical hallmarks are linked to dysfunctional homeostasis inflammation furthermore, both regulated by changes Ca2+ concentration. While many other cellular mechanisms have been considered...
Differentiation of functional limbal stem cells (LSCs) from human pluripotent (hPSCs) is an important objective which can provide novel treatment solutions for patients suffering cell deficiency (LSCD). Yet, further characterization needed to better evaluate their immunogenicity and regenerative potential before clinical applications. Human PSCs were differentiated towards corneal fate cryopreserved using a clinically applicable protocol. Resulting hPSC-LSC populations examined at days 10–11...
Abstract Retinal pigment epithelium (RPE) performs important functions for the maintenance of photoreceptors and vision. Malfunctions within RPE are implicated in several retinal diseases which transplantations stem cell-derived promising treatment options. Their success, however, is largely dependent on functionality transplanted cells. This requires correct cellular physiology, highly influenced by various ion channels RPE, including voltage-gated Ca2+ (CaV) channels. study investigated...
Abstract Human pluripotent stem cell-derived retinal pigment epithelium (RPE) transplantation is currently under evaluation as treatment for macular degeneration. For therapeutic applications, cryostorage during cell production typically needed with potential consequences to functionality. We have previously shown that the culture substrate affects human embryonic RPE (hESC-RPE) properties in fresh cultures. Here, we aimed further identify role of basement membrane proteins type IV collagen...
Abstract Background Transplantation of human pluripotent stem cell-derived retinal pigment epithelium (RPE) is an urgently needed treatment for the cure degenerative diseases retina. The transplanted cells must tolerate cellular stress caused by various sources such as inflammation and regain their functions rapidly after transplantation. We have previously shown maturation level cultured embryonic RPE (hESC-RPE) to influence example calcium (Ca 2+ ) signaling properties. Yet, no comparison...
Pseudoxanthoma elasticum (PXE) is a rare metabolic disease with autosomal recessive inheritance. The manifestation in PXE represented by retinal complications, pseudoxanthomas of the skin folding areas, and arterial calcification. complications are caused calcification Bruch’s membrane beneath pigment epithelial cells (RPE) that can lead to macular degeneration. exact mechanism for pathophysiology not known, patients have variable symptoms findings. Two induced pluripotent stem cell (hiPSC)...