A5047734308- RNA Interference and Gene Delivery
- Influenza Virus Research Studies
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Immunology Research
Korea University
2024
The influenza virus poses a global health burden. Currently, an annual vaccine is used to reduce virus-associated morbidity and mortality. Most vaccines have been developed elicit neutralizing Abs against virus. These primarily target immunodominant epitopes derived from hemagglutinin (HA) or neuraminidase (NA) of the incorporated in vaccines. However, HA NA are highly variable proteins that prone antigenic changes, which can efficacy. Therefore, it essential develop universal conserved...
Teicoplanin (TP) is a glycopeptide antibiotic used for Gram-positive bacterial infections, and it has been reported to inhibit SARS-CoV-2 Ebola virus entry through cathepsin inhibition. Given that TP can viruses belonging different families, we aimed expand the potential targets of determine whether be developed as broad-spectrum antiviral agent. Considering original indication TP, first determined effects against cause respiratory tract infections found inhibits enveloped non-enveloped RNA...