A5042609923- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Surgery and Rehabilitation
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Dermatologic Treatments and Research
- Angiogenesis and VEGF in Cancer
- Surgical Sutures and Adhesives
- Burn Injury Management and Outcomes
- Corneal Surgery and Treatments
- Body Contouring and Surgery
- Venous Thromboembolism Diagnosis and Management
- Medical Practices and Rehabilitation
- Peripheral Artery Disease Management
- Cell Adhesion Molecules Research
- Elbow and Forearm Trauma Treatment
- Breast Implant and Reconstruction
- Diabetic Foot Ulcer Assessment and Management
- Bacillus and Francisella bacterial research
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Interference and Gene Delivery
- Skin Protection and Aging
- Immune Response and Inflammation
University Medical Center Freiburg
2009-2021
University of Freiburg
2003-2019
Stanford Medicine
2009
Universitätsklinik für Chirurgie Wien
2003-2004
Chirurgische Universitätsklinik Heidelberg
1995-2003
Graz University Hospital
2000
Universität Ulm
1997
University Hospital Cologne
1994
University Medical Center New Orleans
1990
Tulane University
1990
Periodontitis affects billions of people worldwide. To address relationships periodontal niche cell types and microbes in periodontitis, we generated an integrated single-cell RNA sequencing (scRNAseq) atlas human periodontium (34-sample, 105918-cell), including sulcular junctional keratinocytes (SK/JKs). SK/JKs displayed altered differentiation states were enriched for effector cytokines periodontitis. Single-cell metagenomics revealed 37 bacterial species with cell-specific tropism....
The perioral region is subject to a myriad of different treatments for rejuvenation, many which are applied without clear understanding the underlying physiological processes aging. results these procedures therefore sometimes not optimal and do achieve natural youthful appearance. aim this study was put three investigations into aging process relation clinical application in aesthetic medicine. Three were performed evaluate complex 3-dimensional changes during process. Perioral proportions...
Research efforts to modify cultured autologous skin transplants for large full-thickness burn wounds and in chronic ulcers have shifted from multilayered differentiated grafts ("sheet" grafts) toward smaller units of basal undifferentiated single cell suspensions a transport medium subconfluently covered static carriers. It has been shown that transplanted with reconstitute the epidermis. However, this technique requires detachment keratinocytes culture flasks by enzymatic...
BACKGROUND: Liposarcoma constitute about 13% of all soft tissue sarcoma and are associated with a high risk metastases. As the preoperative differentiation between benign malign lipomatous tumors is restricted to magnetic resonance imaging, computed tomography biopsy, we performed miRN A array distinguish dedifferentiated liposarcoma patients from healthy controls lipoma patients. METHODS:Blood samples liposarcoma, were collected. Whole blood RNA was extracted (n= 6) donors 4) analyzed using...
Microvesicles are small vesicles expressing specific antigens from their cells of origin. Elevated levels microvesicles have been shown to be associated with coagulation disorders as well different types malignancies. This study aims evaluate a possible correlation microvesicle subpopulations positive history venous thromboembolism (VTE) in patients soft tissue sarcoma.Annexin V - microvesicles, leukocyte (CD45-positive), platelet (CD61-positive), activated (CD62P-, CD63-positive),...
Adipose tissue precursor cells (pre-adipocytes) are part of a stromal vascular fraction that can be easily isolated from fat tissue. harvested by 2 methods: aspiration and excision. We analyzed whether the pre-adipocyte yield, growth characteristics ability to differentiate into mature adipose influenced type harvesting procedure. was simultaneously abdomen surgical excision or according Coleman procedure in 10 individuals. This permitted inter- intra-individual comparisons. Cell viability...
Following the clinical observation of high rate ruptures breast implants French manufacturer Poly Implant Prothèse (PIP), Health Products Safety Agency (Afssaps) removed these products from market in March 2010. Physical and toxicological tests confirmed use silicone improper quality both for shell gel filling. Until now (12/2011), no acute toxicity or mutagenicity could be observed, but 20 cases malignancies occured carriers PIP-prostheses. By means a example, we summarize official...
Background Timely reexploration and reanastomoses can salvage failing free flaps. The use of the implantable Doppler probe provides direct evidence vascular impairment microvascular anastomoses allows for postoperative NPWT. aim this retrospective study was to compare conventional monitoring techniques flap in lower limb reconstruction identify risk factors perfusion disturbance reexploration. Methods All patients receiving muscle soft tissue defects at our department from 2000 2013 were...
ABSTRACT Periodontitis affects billions of people worldwide. To address interkingdom relationships microbes and niche on periodontitis, we generated the first sin-gle-cell meta-atlas human periodontium (34-sample, 105918-cell), harmo-nizing 32 annotations across 4 studies 1–4 . Highly multiplexed immunofluores-cence (32-antibody; 113910-cell) revealed spatial innate adaptive immune foci segregation around tooth-adjacent epithelial cells. Sulcular junctional keratinocytes (SK/JKs) within...
Reconstitution of basement membrane structures after "sandwich-technique" grafting severe deep burns is demonstrated with use immunohistochemical techniques. Cryosections human skin epifascial burn wound excision and sandwich were stained monoclonal antibodies against type IV VII collagen, polyvalent antiserum VI antibody laminin. Standard hematoxylin eosin histologies performed for morphologic correlation. Reorganization the mesenchymal border zone (basement membrane), transplantation...
Evaluation parameters for free flap monitoring devices are used inconsistently, leading to considerable confusion about the quality and applicability of these devices. A comparison different systems clinical series is almost impossible. The ultimate questions that need be answered those regarding efficiency effectiveness system. new tool consisting two simple sufficiently comparably describe developed. failure reduction rate describes percentage saved flaps (effectiveness). revision success...
The aim of this prospective randomised study was to compare Sirotakova's and Lundborg's methods resection-suspension arthroplasty using the abductor pollicis longus tendon in surgical treatment osteoarthritis trapeziometacarpal joint.Between 2009 2012, 38 patients (29 female, 9 male) with symptomatic (34% stage II, 58% III 8% IV according Eaton-Littler classification) were randomly allocated one (mean age 62.7 years, range 43-85). Preoperatively, following data collected: pain intensity...
Enchondromas are common in the hand but less frequent distal phalanges. Epidermal cysts rare when they occur can be difficult to differentiate from enchondromas both clinically and radiologically. Our review of seven phalangeal bone lesions treated over 7 years included four three epidermal cysts. The patients with all had a history previous penetrating trauma 5–8 earlier. One patient an enchondroma injury. Patients presenting injury appear more likely have cyst than enchondroma. This is...
A rare case of isolated traumatic hamate dislocation combined with fracture the hook is reported. Plain X-rays revealed a volar hamate, but computed tomography was necessary to recognise hook. The injury successfully treated open reduction and internal fixation Kirschner wires. Five weeks after operation wires were removed rehabilitation started. At five months follow-up, patient had minimal pain he resumed working. However, his grip strength 50% compared uninjured side. Cone-beam...
Die digitale Volumentomografie (DVT) stellt eine neue Möglichkeit der Schnittbildgebung in Handchirurgie dar. Methode hat letzten Dekade weite Verbreitung Kopf-Hals-Bildgebung gefunden und ist diesem Bereich ein etabliertes Standardverfahren, für das eine, im Vergleich zur Computertomografie (MDCT), niedrigere Strahlenexposition beschrieben wird. Wir berichten über 24 Monate klinische Erfahrung mit dem Einsatz einer handchirurgischen Universitätsklinik. DVT wird bezüglich ihrer Technik sowie...