A5058929083- Antifungal resistance and susceptibility
- Water Systems and Optimization
- Single-cell and spatial transcriptomics
- Antimicrobial Peptides and Activities
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Urban Stormwater Management Solutions
- Hair Growth and Disorders
- Microbial infections and disease research
- Fungal Infections and Studies
- Oral microbiology and periodontitis research
- Bacterial biofilms and quorum sensing
- Immune Response and Inflammation
- Life Cycle Costing Analysis
- Vector-borne infectious diseases
- Fungal and yeast genetics research
- Reliability and Maintenance Optimization
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Laser Applications in Dentistry and Medicine
- Polyamine Metabolism and Applications
- Aquaculture disease management and microbiota
- Building Energy and Comfort Optimization
- Insect and Pesticide Research
Queen Mary University of London
2021-2024
Ada Technologies (United States)
2022
Instituto Politécnico de Lisboa
2019-2021
University of Lisbon
1987-2021
Institute for Biotechnology and Bioengineering
2019-2021
Instituto Superior Técnico
2019-2021
Universidade Federal de Lavras
2005
Universidade Nova de Lisboa
1987-1988
Periodontitis affects billions of people worldwide. To address relationships periodontal niche cell types and microbes in periodontitis, we generated an integrated single-cell RNA sequencing (scRNAseq) atlas human periodontium (34-sample, 105918-cell), including sulcular junctional keratinocytes (SK/JKs). SK/JKs displayed altered differentiation states were enriched for effector cytokines periodontitis. Single-cell metagenomics revealed 37 bacterial species with cell-specific tropism....
Abstract Flavobacterium columnare is an important pathogen of freshwater fish, implicated in skin and gill disease, often causing high mortality. An outbreak disease fingerling adult Nile tilapia, Oreochromis niloticus (L.), cultivated a recirculation system, was investigated. Four strains were isolated characterized by biochemical reactions, enzyme production, fatty acid profile analysis the 16S‐23S rDNA intergenic spacer region. All identified as F. . Experimental infection assays with one...
Candida glabrata is an opportunistic pathogen that adheres to human epithelial mucosa and forms biofilm cause persistent infections. In this work, Single-cell Force Spectroscopy (SCFS) was used glimpse at the adhesive properties of C. as it interacts with clinically relevant surfaces, first step towards formation. Following a genetic screening, RNA-sequencing revealed half entire transcriptome remodeled upon formation, around 40% which under control transcription factors CgEfg1 CgTec1. Using...
Candida glabrata is an emerging fungal pathogen whose success depends on its ability to resist antifungal drugs but also thrive against host defenses. In this study, the predicted multidrug transporter CgTpo4 (encoded by ORF CAGL0L10912g) described as a new determinant of virulence in C. glabrata, using infection model Galleria mellonella. The CgTPO4 gene was found be required for kill G. encoded necessary antimicrobial peptide (AMP) resistance, specifically histatin-5. Interestingly,...
Abstract Introduction and aims Tissue homeostasis in continuously renewing organs, such as the skin, rely on orchestrated cellular molecular dynamics. The hair follicle (HF) is characterized by distinct keratinocytes organized transcriptionally functionally concentric HF layers. anagen progenitor cells (also called germinative layer cells) are located juxtaposed to dermal papilla give rise each of differentiated Despite this well-known high level organization cell-lineage separation, it...
The problem of decaying sewerage systems is a timely topic in many urban areas, due to its importance societal needs and the large amounts capital expeditures needed bring concerned an adequate level serviceability. Thus, there need for better maintenance decision-making related periodic inspection cleaning, repair, rehabilitation or replacement equipment. In this paper, approach offering integrated solutions upgrade such systems, taking into account existing foreseen structural hydraulic...