A5015618600- Effects and risks of endocrine disrupting chemicals
- Heart Rate Variability and Autonomic Control
- Health, Environment, Cognitive Aging
- Noise Effects and Management
- Toxic Organic Pollutants Impact
- Functional Brain Connectivity Studies
- Heavy Metal Exposure and Toxicity
- Transcranial Magnetic Stimulation Studies
- Cardiovascular Issues in Pregnancy
- Carcinogens and Genotoxicity Assessment
- Sexual Differentiation and Disorders
- Estrogen and related hormone effects
- Human Health and Disease
- Cardiac Health and Mental Health
- PI3K/AKT/mTOR signaling in cancer
- Maternal and fetal healthcare
- Hormonal and reproductive studies
- Air Quality and Health Impacts
- Sperm and Testicular Function
- Adipose Tissue and Metabolism
- 14-3-3 protein interactions
- Pregnancy and preeclampsia studies
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Endometriosis Research and Treatment
Swinburne University of Technology
2023-2025
Baker Heart and Diabetes Institute
2023-2024
Monash University
2023-2024
The Alfred Hospital
2024
Hebrew University of Jerusalem
2021
John Brown University
2015-2019
Brown University
2012
University of North Carolina at Chapel Hill
2007-2010
University of Wisconsin–Madison
2008
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2008
ABSTRACT Firemaster® 550 (FM 550), a fire‐retardant mixture used in foam‐based products, was recently identified as common contaminant household dust. The chemical structures of its principle components suggest they have endocrine disrupting activity, but nothing is known about their physiological effects at environmentally relevant exposure levels. goal this exploratory study to evaluate accumulation, metabolism and FM rats exposed 100 or 1000 µg/day across gestation lactation. accumulated...
The study objective was to determine the independent and joint associations of prenatal tobacco childhood lead exposures with attention-deficit/hyperactivity disorder (ADHD), as defined by current diagnostic criteria, in a national sample US children.Data are from 2001-2004 National Health Nutrition Examination Survey, cross-sectional, nationally representative population. Participants were 8 15 years age (N = 2588). Prenatal exposure measured report maternal cigarette use during pregnancy....
Exaggerated blood pressure and vasoconstriction responses during acute mental stress are prospectively associated with an increased risk of hypertension, arrhythmia vascular dysfunction. This study assessed electrophysiological brain power cardiovascular response to psychological concurrent recordings magnetoencephalography, muscle sympathetic nerve activity in 29 healthy participants. Brain was filtered through delta (1-4Hz), theta (4-8Hz), alpha (8-13Hz), beta (13-30Hz), low gamma...
Abstract We recently showed that transcranial alternating current stimulation of the dorsolateral prefrontal cortex modulates spontaneous bursts muscle sympathetic nerve activity, heart rate, and blood pressure (Sesa-Ashton G, Wong R, McCarthy B, Datta S, Henderson LA, Dawood T, Macefield VG. Stimulation activity in humans. Cereb Cortex Comm. 2022:3:2tgac017.). was delivered between scalp electrodes placed over nasion electroencephalogram (EEG) electrode site F3 (left cortex) or F4 (right...
The long-term effect of single intramuscular injections various doses dimeric testosterone and enanthate into castrated male rats upon serum testosterone, luteinizing hormone (LH), pituitary LH, on the weight seminal vesicles, ventral prostate levator ani muscle, was investigated. characterized by a rapid onset protracted androgenic action suppression while brought about only moderate but very even depot effect. injection 5 mg caused positive feedback LH release for 16 weeks. results...
Abstract Skin sympathetic nerve activity (SSNA) is primarily involved in thermoregulation and emotional expression; however, the brain regions generation of SSNA are not completely understood. In recent years, our laboratory has shown that blood-oxygen-level-dependent signal intensity ventromedial prefrontal cortex (vmPFC) dorsolateral (dlPFC) positively correlated with bursts during arousal increases vmPFC occurring spontaneous even resting state. We have recently unilateral transcranial...
Studies evaluating pregnancy outcomes in systemic sclerosis (SSc) are limited. SSc is associated with maternal complications and adverse neonatal outcomes. This study investigated the impact of disease stage (stable vs active) on pregnancies patients followed at an Israeli medical centre.The charts 354 female during 2003-2020 were reviewed. Data clinical laboratory features, number close to diagnosis, analysed. Patients divided into a stable active/early group.The group included 26 [19...
TPS 632: Health effects of flame retardants and plasticizers, Johan Friso Foyer, Floor 1, August 27, 2019, 3:00 PM - 4:30 Background/Aim: Organophosphate (OPFRs) may interfere with growth metabolism through endocrine-related mechanisms. OPFRs are associated adverse pregnancy outcomes such as reduced fertilization live births preterm delivery, but there is little data on their potential to cause other health effects. The objective this pilot study (n = 56 mother-infant pairs) was evaluate the...
Analysis of exposure to environmental chemical mixtures is a well-known issue in epidemiology. Challenges include: numerous potential exposures interest; high degrees correlation between some exposures; non-uniform data distributions; and paucity toxicologic use as guidance when constructing epidemiological models. New methods for epidemiologic analysis are being developed, but it not known how well they perform or compare with conventional approaches. The NIEHS held workshop July 2015...
ISEE-0077 Background and Significance: Bisphenol A (BPA) is an estrogenic monomer used to produce polycarbonate plastics resins in toys, water supply pipes, medical tubing. Prenatal BPA exposure causes aggression hyperactivity rodent offspring, but there are no published human data. Methods: We examined the association between prenatal behavioral problems 249 two-year old children. measured urine at 16 26 weeks gestation birth. Behavioral were by parental report using Assessment System for...
OPS 23: Chemicals and cognitive function, Room 114, Floor 1, August 28, 2019, 1:30 PM - 3:00 Background/Aim: Triclosan exposure may affect thyroid hormone homeostasis subsequently adversely impact childhood cognition behavior. However, there are no studies examining the relationship between triclosan children's academic achievement. Thus, we estimated association gestational urinary concentrations with achievement scores. Methods: Using data from 193 8-year-old children HOME Study,...