A5036528101- Peanut Plant Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nitrogen and Sulfur Effects on Brassica
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Morinda citrifolia extract uses
- RNA Interference and Gene Delivery
- Polyomavirus and related diseases
- Histone Deacetylase Inhibitors Research
- Bioactive Compounds and Antitumor Agents
- Coconut Research and Applications
- HIV/AIDS drug development and treatment
Khon Kaen University
2020-2024
This study investigated the impact of Valencia KK4-type peanut skin ethanolic extract (KK4-PSE) combined with cisplatin or 5-fluorouracil (5-FU) on HeLa cells in vitro and xenograft models. At exposure times 24, 48 72 h, KK4-PSE inhibited growth a half maximal inhibitory concentration (IC
Abstract Application of 5-fluorouracil (5-FU) in cholangiocarcinoma (CCA) is limited by adverse side effects and chemoresistance. Therefore, the combination therapy 5-FU with other substances, especially natural products may provide a new strategy for CCA treatment. The aim this study was to evaluate two ethanolic extracts Thai noni juice (TNJ) on cell lines nude mice xenografts. results antiproliferative assay showed treatment each TNJ extract exerted more cytotoxicity cells than either...
Abstract: This study aimed at investigating the effects of Valencia KK4-type peanut skin ethanolic extract (KK4-PSE) in combination with cisplatin or 5-fluorouracil (5-FU) against HeLa cells vitro and xenograft models. MTT assay showed that KK4-PSE, cisplatin, 5-FU suppressed proliferation a dose time dependent manner. Drug interactions by Chou-Talalay method demonstrated KK4-PSE enhanced antiproliferative activity index (CI) values 0.49 (48 h) 0.60 (72 h), indicating synergistic effect,...
Cholangiocarcinoma is an aggressive cancer with limited treatment options. Current therapies, such as cisplatin and 5-fluorouracil (5-FU), often cause side effects drug resistance. This study investigated a potential new approach by combining peanut skin extract (KK4-PSE) these drugs. The effectively inhibited the growth of cholangiocarcinoma cells in laboratory studies showed even greater selectivity for compared to healthy cells. When combined or 5-FU, KK4-PSE enhanced drugs'...
Cholangiocarcinoma (CCA) is a very aggressive cancer and CCA treatments with cisplatin 5‐fluorouracil (5‐FU) often cause side effects drug resistance. This study aimed to investigate the combined of Valencia KK4‐type peanut’s ( Arachis hypogaea L.) skin ethanolic extract (KK4‐PSE) or 5‐FU on cells in vitro nude mouse xenografts. Antiproliferative activity was evaluated using MTT assay. The interaction studied by Chou–Talalay method. Apoptosis induction cell cycle arrest were analyzed flow...
Objective: To investigate the effect of combination treatments cisplatin and KK4 ICG15042 peanut testa extracts against cholangiocarcinoma cells in vitro.Methods: The growth inhibition, cell cycle arrest apoptosis were determined by 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay flow cytometry analysis, respectively. levels proteins involved assessed using Western blotting assays. caspase activity was a colorimetric assay.Results: Cisplatin (KK4 ICG15042) inhibited lines...