A5075493508- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Cell death mechanisms and regulation
- Lipid Membrane Structure and Behavior
- Medicinal Plants and Bioactive Compounds
- Ion Channels and Receptors
- Berberine and alkaloids research
- Andrographolide Research and Applications
- Silymarin and Mushroom Poisoning
- Bioactive Natural Diterpenoids Research
- Respiratory Support and Mechanisms
- Adenosine and Purinergic Signaling
- Flavonoids in Medical Research
- Phagocytosis and Immune Regulation
Chengdu University of Traditional Chinese Medicine
2022-2025
Abstract Cytokine storm secondary lung injury (CSSLI) is a form of acute (ALI) comparable to that caused by sepsis for which there are no effective therapeutic strategies. Coptis chinensis Franch. and Scutellaria baicalensis Georgi. two botanical medicines exhibit anti‐inflammatory properties. This study aimed investigate the underlying mechanism combination (CCSB) treatment in mice with ALI. A high dosage lipopolysaccharide (LPS) was administered intraperitoneally C57BL/6 establish an ALI...
The assembly of inflammasomes drives caspase-1 activation, which further promotes proinflammatory cytokine secretion and downstream pyroptosis. discovery novel inhibitors is pivotal to developing new therapeutic means for inflammasome-involved diseases. In our present study, sennoside A (Sen A), a popular ingredient in multiple weight-loss medicines dietary supplements, found potently inhibit the enzymatic activity vitro. Sen considerably decreased IL-1β production macrophages stimulated by...
Cell death is a fundamental process in all living organisms. The protocol establishes lipopolysaccharide (LPS) and adenosine triphosphate (ATP)-induced phorbol-12-myristate-13-acetate (PMA)-differentiated lipid deposition human monocyte (THP-1) macrophage model to observe cell death. LPS combined with ATP classic inflammatory induction method, often used study pyroptosis, but apoptosis necroptosis also respond stimulation by LPS/ATP. Under normal circumstances, phosphatidylserine only...
Cell death is a fundamental process in all living organisms. The protocol establishes lipopolysaccharide (LPS) and adenosine triphosphate (ATP)-induced phorbol-12-myristate-13-acetate (PMA)-differentiated lipid deposition human monocyte (THP-1) macrophage model to observe cell death. LPS combined with ATP classic inflammatory induction method, often used study pyroptosis, but apoptosis necroptosis also respond stimulation by LPS/ATP. Under normal circumstances, phosphatidylserine only...
The assembling of inflammasomes drive caspase-1 activation which further undertakes the proinflammatory cytokines secretion and downstream pyroptosis. Discovery novel inhibitors is pivotal to develop new therapeutic means for inflammasome-involved diseases. In our present study, sennoside A (Sen A) potently inhibit enzymatic activity in vitro. Sen considerably decreased IL-1β production macrophages stimulated by LPS plus ATP, nigericin or MSU, as well poly (dA:dT) transfection, rescued...