A5101704096- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Rheumatoid Arthritis Research and Therapies
- Flavonoids in Medical Research
- Neuroscience and Neuropharmacology Research
- Medicinal Plants and Bioactive Compounds
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Phytochemistry and biological activity of medicinal plants
- Phytochemical and Pharmacological Studies
- Antioxidant Activity and Oxidative Stress
- Phytochemistry and Biological Activities
- Chromatography in Natural Products
- Glaucoma and retinal disorders
- Cell death mechanisms and regulation
- Lipid Membrane Structure and Behavior
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Advanced Glycation End Products research
- Gout, Hyperuricemia, Uric Acid
- Angiogenesis and VEGF in Cancer
- Medicinal Plants and Neuroprotection
- Animal Ecology and Behavior Studies
- Neonatal and fetal brain pathology
- Natural product bioactivities and synthesis
Chengdu University of Traditional Chinese Medicine
2012-2024
Scutellarin (Scu), a flavonoid from herbal Erigeron breviscapus (Vaniot) Hand-Mazz, exerts neuroprotective effects against cerebral ischemia. However, whether the of Scu are related to mitochondrial protection needs further investigation. In this study, we aimed clarify mechanisms HT22 cells injury caused by oxygen-glucose deprivation and reperfusion (OGD/R). Our results proved that significantly reduced overload intracellular reactive oxygen species (cellar ROS) mitochondria (mito-ROS),...
Abstract Siwei Jianghuang Decoction Powder (SWJH) documented originally in the Four Medical Tantras-Blue Glaze exhibited beneficial effects on diabetic nephropathy (DN) via combined synergistically action of multiple formula components including Curcumae longae Rhizoma, Berberidis dictyophyllae Cortex, Phyllanthi Fructus and Tribuli Fructus. This study investigated SWJH DN db/db mice possible underlying mechanisms. The ten weeks old treated with by intra-gastric administration once a day for...
Pterocephalus hookeri (C. B. Clarke) Hock., a traditional Tibetan herbal medicine rich in glycosides, has been used to treat several diseases including rheumatoid arthritis.To evaluate the anti-arthritic activity of total glycosides from P. hookeri, and its possible mechanisms action.Anti-arthritic (oral administration for 30 days at 14-56 mg/kg) was evaluated using paw swelling, arthritis scores histopathological measurement adjuvant-induced (AA) Sprague-Dawley rats. The NF-κB p65...
According to Traditional Chinese Medicine (TCM), Aconiti Radix Cocta (AC) is clinically employed expel wind, remove dampness, and relieve pain. We evaluated the antirheumatoid arthritis (RA) activities underlying mechanisms of AC. The chemical constituents AC were analyzed by high-performance liquid chromatography (HPLC) using three reference compounds (benzoylaconitine, benzoylmesaconine, benzoylhypacoitine). anti-RA effects in adjuvant-induced (AIA) rats hind paw volume histopathological...
The aim was to evaluate the protective effects of total flavones Elaeagnus rhamnoides (L.) A. Nelson (TFE) against vascular endothelial injury in blood stasis model rats and explore potential mechanisms preliminarily. rat with induced by subcutaneous injection adrenaline combined ice-water bath. Whole viscosity (WBV), histological examination, prothrombin time (PT), activated partial thromboplastin (APTT), fibrinogen (FIB) were measured. Meanwhile, levels Thromboxane B2 (TXB 2 ), 6-keto-PGF...
The blood-brain barrier (BBB) is a dynamic physiological structure composed of microvascular endothelial cells, astrocytes, and pericytes. By coordinating the interaction between restricted transit harmful substances, nutrient absorption, metabolite clearance in brain, BBB essential preserving central nervous system homeostasis. Building vitro models valuable tool for exploring pathophysiology neurological disorders creating pharmacological treatments. This study describes procedure an...
Context: Tsothel, a traditional Tibetan medicine, is regarded as ‘the king of essences’. Nevertheless, tsothel has aroused serious concern regarding its biosafety because main component HgS. Unfortunately, toxicological studies on are scarce.Objective: As inorganic mercury high affinity for the kidney, present investigation was designed to determine potential nephrotoxicity and mechanism tsothel.Materials methods: Sprague-Dawley rats were orally administered different doses (0, 66.70, 33.35...
Cell death is a fundamental process in all living organisms. The protocol establishes lipopolysaccharide (LPS) and adenosine triphosphate (ATP)-induced phorbol-12-myristate-13-acetate (PMA)-differentiated lipid deposition human monocyte (THP-1) macrophage model to observe cell death. LPS combined with ATP classic inflammatory induction method, often used study pyroptosis, but apoptosis necroptosis also respond stimulation by LPS/ATP. Under normal circumstances, phosphatidylserine only...
Zha-xun is widely used in Tibetan medicine and also an international traditional medicine. This article would summarize the use status research progress of by various ethnic groups all over world, results show that it has synonyms but most them imply its characteristic feature-outflow from rock; resources are distributed places bearing spots closely related to geological structure; there sharp arguments on origins Zha-xun, mainly including minerals origin, biological fossils etc. multiple...
According to the findings, modified Ganlu Yaoyu San has a good anti-inflammatory activity, and can significantly alleviate degree of arthritis. Its therapeutic effect for rheumatoid arthritis may be related regulation MAPK pathway synovial cells. In study, rat adjuvant arthritis(AA) model was established further investigate pharmacodynamic mechanism regulating Enzyme-linked immune assay used determine serum TNF-α level AA rats administered with drug two weeks, tissue protein kinases ERK1/2...
To observe the effect of long-term external use Goupi Gao on renal function and lead accumulation in rats.Rats were externally administered with at different doses (7, 3.5 1.75 g x kg(-1)) for 90 d. At 45 days after administration, indicator, levels blood urea nitrogen (BU) creatinine (Cr) serum, beta2-microglobulin (beta2-MG) N-acetyl-beta-D-glucosaminidase (NAG) urine determined. Lead content kidneys was detected by atomic absorption spectrometry.A 90-day administration significantly...