A5025699509- Celiac Disease Research and Management
- Microscopic Colitis
- Digestive system and related health
- Eosinophilic Esophagitis
- Pediatric Hepatobiliary Diseases and Treatments
- Microbial Metabolites in Food Biotechnology
- Gastrointestinal disorders and treatments
- Infant Health and Development
- Gastrointestinal motility and disorders
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Liver Disease and Transplantation
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Selenium in Biological Systems
- Congenital Anomalies and Fetal Surgery
- Consumer Attitudes and Food Labeling
- Genetic Syndromes and Imprinting
- Growth Hormone and Insulin-like Growth Factors
- Gallbladder and Bile Duct Disorders
- Child Nutrition and Feeding Issues
- Viral-associated cancers and disorders
- Gastroesophageal reflux and treatments
- Metabolism and Genetic Disorders
Stanford University
2024-2025
Palo Alto University
2025
Lucile Packard Children's Hospital
2023-2024
University of Chicago
2014-2022
Comer Children's Hospital
2014-2021
University of Chicago Medical Center
2017-2021
Palmerston North Hospital
2019
Lurie Children's Hospital
2012-2014
Boston Children's Hospital
2013
The University of Queensland
2003
The aim of the study was to evaluate effectiveness gluten-free diet (GFD) on extraintestinal symptoms in pediatric and adult celiac populations at University Chicago.We conducted a retrospective chart review Chicago Celiac Center clinic charts from January 2002 October 2014. Demographics, serologic testing, intestinal biopsies, presentation, 12, 24, >24 months were recorded. Extraintestinal included abnormal liver enzymes, arthralgia/arthritis, dermatitis herpetiformis, alopecia, fatigue,...
The aim of the study was to evaluate efficacy gluten-free diet (GFD) on gastrointestinal (GI) and extra-intestinal (EI) symptom resolution identify predictors for persistence symptoms in all celiac patients at University Chicago.We conducted a retrospective chart review from 2002 2015. GI included abdominal pain, bloating, constipation, diarrhea, failure thrive/weight loss, nausea, reflux, vomiting. EI abnormal liver enzymes, arthralgia/arthritis, dermatitis herpetiformis, alopecia, fatigue,...
Background: Histological changes induced by gluten in the duodenal mucosa of patients with non-coeliac sensitivity (NCGS) are poorly defined. Objectives: To evaluate structural and inflammatory features NCGS compared to controls coeliac disease (CeD) milder enteropathy (Marsh I-II). Methods: Well-oriented biopsies 262 control cases normal gastroscopy histologic findings, 261 CeD, 175 from 9 contributing countries were examined. Villus height (VH, μm), crypt depth (CrD, villus-to-crypt ratios...
Celiac disease (CeD), an autoimmune disorder triggered by gluten ingestion, induces intestinal inflammation and varied symptoms. Treatment entails a strict gluten-free diet (GFD), posing challenges for students, especially in schools with limited food choices. Nonadherence worsens symptoms, yet research on CeD's impact students is scarce. The CeliacKIDS study, conducted across 11 United States academic medical centers, evaluated exposure risk pediatric CeD patients via cross-sectional survey...
ABSTRACT Since the first description of celiac disease (CeD) by Samuel Gee in 1888 and later “miraculous discovery” that bread was responsible for this condition following World War II Europe, there has been an exponential growth knowledge regarding CeD. Just when we thought knew everything to know about it, is, however, offering new challenges, with its presentation having significantly morphed over years from cases overt gastrointestinal symptoms, malnutrition, atrophic villi on duodenal...
Partial external bile diversion (PEBD) is an established therapy for low-γ-glutamyl transferase (GGT) progressive familial intrahepatic cholestasis (PFIC). This study sought to determine whether the dynamics of cholic acid (CA) and chenodeoxycholic (CDCA) pools in subjects with low-GGT-PFIC successful PEBD were equivalent those achieved liver transplantation (LTX).The kinetics CA CDCA metabolism measured by stable isotope dilution plasma samples 5 PEBD, all intact canalicular salt export...
The effects of gluten free diet (GFD) on body mass index (BMI) and growth parameters in pediatric patients with celiac disease (CD) their dependence different socio-cultural environments are poorly known. We conducted an international retrospective study diagnosed at the University Verona, Italy, Chicago, IL, USA, as underweight. A total 140 children controls (mean age 8.4 years) were enrolled Chicago; 125 7.3 years, NS) Verona. At time diagnosis, Italian had a weight slightly lower (p =...
Insulin-like growth factor II (IGF-II) and its receptor, the IGF-II/mannose-6-phosphate (IGF-II/M6P) are first expressed from zygotic genome at two-cell stage of mouse development. However, their role is not clearly defined. believed to mediate through heterologous type 1 IGF insulin receptors, whereas IGF-II/M6P receptor act as a negative regulator somatic by limiting availability excess levels IGF-II. These studies demonstrate that IGF-II does have in regulation early embryo receptor....
Abstract Objectives The prevalence of celiac disease (CeD) is increasing, yet it still underdiagnosed, in part because its heterogeneous presentation. Diagnostic criteria are evolving and management with strict adherence to a gluten‐free diet challenging for many. We aimed characterize the clinical presentation CeD among large multicenter cohort pediatric patients identify factors associated adherence. Methods Patients aged 0–18 years were recruited from 11 United States health centers....
The aim of the study was to determine effects gluten-free diet (GFD) on body mass indexes (BMIs) in children with celiac disease at University Chicago before and after 2011, when processed foods became readily available market.We conducted a retrospective chart review seen Celiac Center from January 2002 May 2016. BMI recorded upon GFD initiation addition least 1 other timepoint: 6 months, year, 2 years, 3 4+ years. We compared rate increase who were diagnosed versus 2011.A total 147 (66%...
Epstein-Barr virus (EBV)–associated smooth muscle tumors (SMTs) have increasingly been recognized in children (1), typically following solid organ and stem cell transplantation, chemotherapy for malignancies, immunosuppressed states such as acquired immunodeficiency syndrome (1–3). We report a case of successful treatment an EBV-associated SMT with rituximab, 2.5-year-old girl, 15 months liver transplantation biliary cirrhosis. To the best our knowledge, this is first rituximab used SMT. The...
Selenium is an essential micronutrient that must be supplemented in infants and young children on exclusive parenteral nutrition (PN). We examined selenium status clinical factors associated with a deficiency PN.This was retrospective cohort study of pediatric patients receiving PN routine monitoring status. Deficiency diagnosed using age-based norms plasma Associations between the following were examined: birthweight status: extremely low (ELBW) versus very (VLBW) (LBW) normal (NBW), serum...
ABSTRACT An expanding gluten‐free marketplace has left children with celiac disease and their families a host of new dietary options. The quality these foods is inconsistent processed items may be high in caloric content while lacking nutritional value. Assessing the preferences cohort via cross‐sectional survey, we find that food have become staple diet, many cases, are consumed to exclusion healthy alternatives. Furthermore, less interested education over time, indicating greatest...
This issue of AM:STARs, Hot Topics in Adolescent Health, presents a wide array articles exploring some the most exciting advances and controversies adolescent health. These topics other evolving areas are presented to guide reader toward providing state art clinical care adolescents, as well reviewing new research that will shape future health.Topics include:Nutritional metabolic including diagnosis gluten intolerance, vitamin D deficiency syndrome use bariatric surgery treat comorbidities...
To test the impact of celiac disease (CD) and depression symptoms on quality life in adolescent patients.We conducted a prospective survey 12- to 18-year-old patients their caregivers between January 2015 November 2016. Enrolled parents youth completed standard measures adjustment disease, depression, life.We enrolled 105 with CD parents. Both reported high levels symptoms. There were no associations age, duration CD, or following gluten-free diet (GFD) life. No significant found perception...
Strict adherence to a gluten-free diet (GFD), the current treatment for celiac disease (CD), is socially challenging adolescents, especially in college setting. We conducted survey of factors contributing GFD during among patients meeting ESPGHAN criteria CD. One-hundred-one young adults (18 years and older) were contacted; 59 completed survey, which 47 enrolled or had attended college. The was developed by study team. Most able maintain strict GFD, whereas at reported that GF food available...