A5007030379- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Luminescence Properties of Advanced Materials
- Solid-state spectroscopy and crystallography
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Nuclear materials and radiation effects
- Crystallography and molecular interactions
- Nuclear Materials and Properties
- Advanced Semiconductor Detectors and Materials
- Physics of Superconductivity and Magnetism
- Glass properties and applications
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Optical and Acousto-Optic Technologies
- 3D Printing in Biomedical Research
- High-pressure geophysics and materials
- Intraperitoneal and Appendiceal Malignancies
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Pigment Synthesis and Properties
- Mechanical Behavior of Composites
- Inorganic Fluorides and Related Compounds
- Smart Materials for Construction
- Semiconductor materials and devices
Duke-NUS Medical School
2024-2025
Nagoya Institute of Technology
2021
Kyoto University
2019
Osaka International Cancer Institute
2018
Osaka Red Cross Hospital
2012
Nara Institute of Science and Technology
2004
Osaka Kyoiku University
1976-1991
Osaka University
1978
Abstract Gastric cancer (GC) is a major cause of global mortality with high levels heterogeneity. To explore geospatial interactions in tumor ecosystems, we integrated 2,138 spatial transcriptomic regions-of-interest (ROIs) 152,423 single-cell expression profiles across 226 GC samples from 121 patients. We observed pervasive expression-based intratumor heterogeneity, recapitulating progression through spatially localized and functionally ordered subgroups associated specific immune...
Peritoneal metastasis (PM) in gastric cancer (GC) is associated with poor prognosis and significant morbidity. We sought to understand the genomic, transcriptomic, tumor microenvironment (TME) features that contribute peritoneal organotropism GC.
Solid-state films of chiral polysilanes undergo an optical inversion (see Figure) above a helix–helix transition temperature, determined by the polymer molecular weight and thermal processing. These could be used for re-writable or write-once, read-many data storage, depending on temperature. Supporting information this article is available WWW under http://www.wiley-vch.de/contents/jc_2089/2004/c0470_s.pdf from author. Please note: The publisher not responsible content functionality any...
<div>Abstract<p>Gastric cancer is a major cause of global mortality. To explore geospatial interactions in gastric tumors, we integrated 2,138 spatial transcriptomic regions interest with 152,423 single-cell expression profiles across 226 samples from 121 patients. We observed pervasive expression-based intratumor heterogeneity, recapitulating tumor progression through spatially localized and functionally ordered subgroups associated specific immune microenvironments, checkpoint...
<p>(1) Supplementary Figure 1 shows morphologies of different ROI categories and their representative genes, pathways similarities with paired scRNA-seq data. (2) 2 validation findings from the discovery GeoMx DSP cohort in whole-section also TMA cohort. (3) 3 experiments validating that intratumor G1/G2 subregion expression is tumor-intrinsic using multiplexed IHC, Stereoseq spatial transcriptomics, vitro drug treatment profiling. (4) 4 individual immune checkpoints, chemokines,...
Abstract Purpose: Peritoneal metastases (PM) in colorectal cancer (CRC) portend a poor prognosis. We sought to elucidate molecular features differentiating primary tumors (PTs) from PMs and actionable targets facilitating transcoelomic dissemination progression. Experimental Design: performed multi-omic profiling of 227 samples 136 patients, including 56 tumor (PT) 120 synchronous comprising 34 matched PT-PM pairs. Whole exome, bulk RNA-seq analysis was conducted identify underlying genomic...
Abstract Cancer cells are exposed to various stresses in vivo , including hydrodynamic stress (HDS). HDS on cancer the blood stream can influence metastatic potential. Recent studies revealed that circulating tumor cell clusters more responsible for metastasis than single cells. Nevertheless, most based prepared from established lines. Here, we used tissue-originated spheroids (CTOS) as a patient-derived, 3D organoid model investigate effect of clusters. We found induced growth population...
Individual and small clusters of cancer cells may detach from the edges a main tumor invade vessels, which can act as origin metastasis; however, mechanism for this phenomenon is not well understood. Using tissue-originated spheroids, we studied whether disturbing 3D architecture spheroids provoke reformation process progression malignancy. We developed mechanical disruption method to achieve homogenous while maintaining cell-cell contact. After disruption, 9 spheroid lines patient samples...
X-ray fluorescence holography (XFH) measurements were carried out for multiferroic $\mathrm{Pb}({\mathrm{Fe}}_{1/2}{\mathrm{Nb}}_{1/2}){\mathrm{O}}_{3}$ (PFN) single crystal to investigate variations in the local structures around Nb ions with decreasing temperature from 300 100 K, combination single-crystal x-ray diffraction (XRD) experiments. We find that Nb--Pb correlation is more significantly changed by cooling than average structure derived XRD experiments, indicating a mobile feature...
Abstract PURPOSE HER2-positive gastric cancer (HER2+ GC) exhibits significant intra-tumoral heterogeneity and frequent development of resistance to HER2-targeted therapies. This study aimed characterize the spatial tumor microenvironment (TME) in HER2+ GC identify mechanisms HER2 blockade including trastuzumab deruxtecan (T-DXd), with goal informing novel therapeutic strategies. PATIENTS AND METHODS We performed transcriptomics on pre-and post-treatment samples from patients metastatic who...
The property of single halogen interstitials as the hardening agent has been studied through experiments using KBr doped with alkali impurity. Thermal recovery radiation-induced increment flow stress Δτ, and thermal annealing color centers in : Na Li are measured by means an isochronal pulse-annealing technique. Single-intersititial-type centers, HA IA decay at nearly same temperature around 100 K 210 Li, which is accompanied decrease a considerable amount Δτ both samples. effects optical...
The interaction of single halogen interstitials and dislocations has been studied in terms their elastic interaction. linear-elastic calculation is made to show that the maximum force I-center–dislocation greater than case H center. This result shown be relevant for HA IA centers with dislocations. We reveal relation between magnitude strain around a defect, conclude hardening effect interstitial ion atom originates from stronger elastic-interaction caused by larger ion. compared VK
Abstract Peritoneal metastases (PM) in gastric cancer (GC) portend a poor prognosis, yet our understanding of tumor microenvironmental (TME) characteristics associated with GCPM remain limited. Here, we analyzed intrinsic genomic alterations and transcriptomic programs predictive prospective cohort 248 patients, identifying CDH1 , PIGR ELF3 mutations as predictors. By inspecting the spatial dynamics TME, find that compartment infiltration pro-tumorigenic cell types such inflammatory...
Abstract Gastric cancer is highly heterogeneous. To analyze their biology, patient-derived organoids (PDOs) are useful because they maintain intra-tumor heterogeneity (ITH) as well inter-patient heterogeneity. Recently, four groups reported the establishment of gastric PDOs. However, it still not easy need to overcome a common problem: “contamination” culture with “non-cancer cell”-derived from specimen. These non-cancer often overgrow and became dominant. Furthermore, PDOs have another...
Le mouvement ionique anisotrope et les propriétés de dipôle (K + -V,), l'ion du potassium la vacance d'iode, ont été étudiés en mesurant d.c.conductivité ionique, perte diélectrique (DL) le thermocourant (ITC).Les énergies migratoires V,-par l'application champ électrique parallèle (cas I) ou perpendiculaire II) à l'axe c des cristaux se sont révélés être même valeur 0,26 eV dans échantillons dopés K. ions.D'autre part, l'énergie migratoire ions plomb telle que 0,58 cas I 0,35 II.Le maximum...