A5002583803- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Bariatric Surgery and Outcomes
- Diabetes Management and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
Shanghai First People's Hospital
2023
Shanghai Jiao Tong University
2023
Third Affiliated Hospital of Sun Yat-sen University
2015-2021
Sun Yat-sen University
2015-2021
Chinese PLA General Hospital
2015
Tianjin Infectious Diseases Hospital
2015
Tianjin Medical University
2015
China-Japan Friendship Hospital
2015
Second Xiangya Hospital of Central South University
2015
Central South University
2015
Abstract Aims/hypothesis The study aimed to investigate the effects of HLA class I genes on susceptibility type 1 diabetes with different onset ages, in addition well-established II genes. Methods A total 361 patients (192 <18 years and 169 ≥18 years) 500 healthy control participants from China were enrolled genotyped for HLA-A , -B -C -DQA1 -DQB1 -DRB1 using next-generation sequencing. Results susceptible DR3 (β = −0.09, p 0.0009) DR4-DQ8 −0.13, 0.0059) haplotypes negatively associated...
Abstract Background The aim of this study was to investigate differences in clinical features and HLA genotypes between adult‐onset childhood‐onset patients with type 1 diabetes a Chinese population. Materials Methods This enrolled 716 Han from Guangdong (258 458 adult‐onset) compare their features. Of them 214 classical (100 114 were selected for DR DQ genotyping by next‐generation sequencing. Results Adult‐onset characterized longer duration symptoms before diagnosis, lower frequency DKA...
Objectives To investigate the status of self-monitoring blood glucose(SMBG) in adults with type 1 diabetes mellitus(T1DM) Guangdong Province, and to explore its related factors. Methods Adults T1DM from Type Diabetes Translational Study were enrolled this cross-over survey 2010 2014. Demographic data clinical information(frequency SMBG (SMBG-F) record diabetic education) was collected. After grouped by SMBG-F, linear trend among SMBG-F groups analyzed one-way analysis...
The aim of our study is to investigate whether preproinsulin (PPI) could trigger a proinflammatory CD4+ T cell response in Chinese patients with type 1 diabetes (T1D).Peripheral blood mononuclear cells were stimulated by pool 13 PPI peptides. Additional five peptides previously proved be antigenic other cohorts T1D also used. reactive responses measured interferon (IFN)-γ ELISPOT assay.Fifty-one enrolled this and 72.34% them positive for at least one islet autoantibody. stimulation index...
Objective: To determine the association of NH2-terminal pro-B-type natriuretic peptide (NT-proBNP) with risk developing type 2 diabetes.Methods: We conducted a prospective analysis impaired glucose regulation participants from Diabetic Identification Center Tianjin Metabolic
Type 1 diabetes (T1D) is an autoimmune disease in which auto-reactive T cells infiltrate the pancreatic islets and destroy insulin-producing β cells. Preproinsulin (PPI) considered as important autoantigen for developing T1D Caucasian population, particularly those bearing associated susceptible alleles DRB1*04:01, DQA1*03:01 DQB1*03:02. However, whether PPI could trigger similar responses Chinese patients remains elusive. Peripheral blood mononuclear from 19 newly diagnosed (Mean Age...
Association between HLA class I genes and onset ages of type 1 diabetes (T1D) has been reported in Europeans—risk A*2402 B*3906 were associated with an earlier age at onset. However, there exists considerable heterogeneity different populations individuals T1D. Its incidence varies dramatically by country region, ranging from &gt; 60 per 100000 persons years Finland to 1.01 China. With latter, as many 65% the newly diagnosed patients occurred among adults. Furthermore, little is known...