A5101611378- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Ferroptosis and cancer prognosis
- Artificial Intelligence in Healthcare and Education
- Radiomics and Machine Learning in Medical Imaging
- Iron Metabolism and Disorders
- COVID-19 diagnosis using AI
- Inflammasome and immune disorders
- Machine Learning in Healthcare
- Liver Disease Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Diabetes and associated disorders
- Aluminum toxicity and tolerance in plants and animals
- Autophagy in Disease and Therapy
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Diet, Metabolism, and Disease
- Resilience and Mental Health
- Pancreatic function and diabetes
- Acute Kidney Injury Research
- Hydrogen's biological and therapeutic effects
- Cancer Mechanisms and Therapy
Second Affiliated Hospital of Nanchang University
2020-2025
Nanchang University
2020-2025
Second Affiliated Hospital of Zhejiang University
2025
Tianjin Medical University Cancer Institute and Hospital
2022-2025
Changchun University of Chinese Medicine
2025
Development Research Center
2024
Army Medical College
2024
Army Medical University
2024
National Clinical Research Center for Digestive Diseases
2023
Nanjing Medical University
2023
Ischemia/reperfusion (I/R) injury is a life-threatening vascular emergency following myocardial infarction. Our previous study showed cardioprotective effects of metformin against I/R injury. In this study, we further examined the involvement AMPK mediated activation NLRP3 inflammasome in effect metformin. Myocardial was simulated rat heart Langendorff model and neonatal ventricle myocytes (NRVMs) were subjected to hypoxi/reoxygenation (H/R) establish an vitro model. Outcome measures...
Objective: Research suggests that Puerarin may protect against sepsis-induced myocardial damage. However, the mechanisms responsible for Puerarinâs cardioprotective effect remain largely unclear. In this study, our objective is to investigate role of Puerarin-induced AMPK-mediated ferroptosis signaling in protecting injury. Methods: 48 male Sprague-Dawley rats were randomly divided into four groups: control group, LPS + Pue Era (Erastin, activator) or CC (compound C, AMPK inhibitor) group....
ChatGPT, an artificial intelligence (AI) system powered by large-scale language models, has garnered significant interest in healthcare. Its performance dependent on the quality and quantity of training data available for a specific language, with majority it being English. Therefore, its effectiveness processing Chinese which fewer available, warrants further investigation. This study aims to assess ChatGPT's ability medical education clinical decision-making within context. We utilized...
While epidemiological data suggest a connection between atopic dermatitis (AD) and COVID-19, the molecular mechanisms underlying this relationship remain unclear. To investigate whether COVID-19-related CpGs may contribute to AD development association is mediated through regulation of specific genes' expression. We combined Mendelian randomization transcriptome analysis for data-driven explorations. Among 172 -associated with COVID-19 infection, merely 3 them exhibited significant impacts...
Abstract Background Klotho has both anticancer and hormone‐like functions. But the research on cancer is mainly based animal experiments small‐scale clinical research, thus we explored association between serum mortality National Health Nutrition Survey (NHANES). Methods Participants were employed from NHANES 2007–2016, excluding pregnant, chronic renal insufficiency, incomplete data of questionnaire level. The with was analyzed by weighted Logistic regression, Cox regression competitive...
Background ChatGPT, an artificial intelligence (AI) based on large-scale language models, has sparked interest in the field of health care. Nonetheless, capabilities AI text comprehension and generation are constrained by quality volume available training data for a specific language, performance across different languages requires further investigation. While harbors substantial potential medicine, it is imperative to tackle challenges such as formulation clinical care standards;...
Background: Resilience is a characteristic and skill that nurses can learn. This study examined the current state influencing factors of nurse resilience perceived job-related stressors. Method: cross-sectional survey was conducted at university-affiliated hospital in China between May August 2018. The Connor-Davidson Scale used to measure resilience. Results: A total 2,981 participated study, with an average score 61.35 ± 13.12. Nurse significantly correlated age, years employment, clinical...
Abstract Background Fatty liver disease may be associated with increased risks of intrahepatic and extrahepatic cancers. Our objective was to investigate associations between new subcategories steatotic (SLD) recently proposed by nomenclature consensus group cancer risk. Methods A total 283 238 participants from the UK Biobank were included. Based on information cardiometabolic factors, alcohol consumption specific aetiology SLD, individuals categorized into four groups: no SLD ( n = 170...
Abstract Background: Sarcopenia is a risk factor for chronic non-communicable diseases. The serum creatinine (Cr)/cystatin C (CysC) ratio (CCR) and the sarcopenia index (SI) have attracted attention as surrogate marker but not been adequately studied in general population. We aimed to explore relationships of CCR SI with major diseases [cancer, cardiovascular disease (CVD), respiratory disease], investigate validity predictors propose statistical cut-off values. Methods: utilized two...
We aimed to explore the relationships between mobile phone addiction and cognitive failures in adolescents. Our study sample consisted of 816 adolescents from two high schools China (female = 413; mean age 15.86 years, SD 0.80 years). The completed Smartphone Addiction Scale–Short Version, Mindfulness Attention Awareness Scale, Ruminative Responses Cognitive Failures Questionnaire. Structural equation modelling multiple mediation analysis showed that predicted scores on rumination low...
Abstract The development of resistance in hepatocellular carcinoma (HCC) cells limits the effectiveness sorafenib, but combination therapy with other drugs may have a positive effect. However, effect ropivacaine combined sorafenib on treatment HCC and its potential regulatory mechanisms remain unclear. proliferation apoptosis treated ropivacaine, plus were analyzed by cell‐counting kit 8 flow cytometry. protein levels measured Western blot. antitumor their was verified tumor xenograft model....
The mortality and therapeutic failure in lung adenocarcinoma (LUAD) are mainly resulted from the wide metastasis chemotherapy resistance. Up to now, accurate stable predictive prognostic indicator for revealing progress novel strategies of LUAD is infrequent, nonetheless. Diversified programmed cell death (PCD) has been widely confirmed that participated occurrence development various malignant tumors, respectively. In this research, we integrated fourteen types PCD, bulk multi-omic data...
Background: Increasing evidence demonstrate that tryptophan metabolism is closely related to the development of NAFLD. This study aimed identify specific biomarkers NAFLD associated with and researched its function mechanism. Methods: We downloaded RNA-sequencing data from GSE89632 GSE24807 got metabolism-related genes (TMRGs) MsigDB database. R package Limma WGCNA were used TMRGs-DEGs GO, KEGG, cytoscape analyse visualize data. Immune cell infiltration analysis was explore immune mechanism...
ABSTRACT Background Individuals with metabolic dysfunction‐associated steatotic liver disease (MASLD) have a higher mortality risk, and physical activity is important to MASLD management. However, comprehensive exploration of associations volume intensity rest‐activity rhythm (RAR) based on an accelerometer all‐cause cause‐specific in individuals was scarce. Methods We included 10,143 from the UK Biobank. Volume [low‐intensity (LPA), moderate‐to‐vigorous‐intensity (MVPA) sedentary time] RAR...
Copper (Cu) homeostasis and Cu-induced cell death are gaining recognition as crucial processes in the pathogenesis of cardiovascular disease (CVD). Circulating Cu associated with CVD mortality is yet to be fully elucidated.This national prospective cohort study estimate relationship between serum risk all-cause mortality.This included participants from National Health Nutrition Examination Survey 2011-2016. Weighted Cox proportional hazards regression analysis exposure-response curves were...
Background: The ChatGPT, a Large-scale language models-based Artificial intelligence (AI), has fueled interest in medical care. However, the ability of AI to understand and generate text is constrained by quality quantity training data available for that language. This study aims provide qualitative feedback on ChatGPT's problem-solving capabilities education clinical decision-making Chinese.Methods: A dataset Clinical Medicine Entrance Examination Chinese Postgraduate was used assess...
The objective was to explore the association between serum copper levels and prevalence of stroke.
Abstract Background The ChatGPT, a Large-scale language models-based Artificial intelligence (AI), has fueled interest in medical care. However, the ability of AI to understand and generate text is constrained by quality quantity training data available for that language. This study aims provide qualitative feedback on ChatGPT’s problem-solving capabilities education clinical decisionmaking Chinese. Methods A dataset Clinical Medicine Entrance Examination Chinese Postgraduate was used assess...
With the spread of COVID-19, concerns regarding its adverse effects have arisen. Based on affect regulation theory and construal level theory, this study explored how COVID-19 affects intertemporal choice in health economy domains, self-other differences for were also inspected. The examined whether psychological safety can moderate relationship between choice.