A5093028200- Receptor Mechanisms and Signaling
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Diabetes Treatment and Management
- Neuropeptides and Animal Physiology
Karolinska Institutet
2023-2024
Abstract G protein-coupled receptors are important drug targets that engage and activate signaling transducers in multiple cellular compartments. Delineating therapeutic from associated with adverse events is an step towards rational design. The glucagon-like peptide-1 receptor (GLP-1R) a validated target for the treatment of diabetes obesity, but drugs this frequent cause events. Using recently developed biosensors, we explored ability GLP-1R to 15 pathways 4 compartments demonstrate...
Abstract Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here we report that Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing vital role in infection culture blood vessel organoids. The interaction between LDLR specific, with other members protein family failing bind or neutralize virus. Biosensor experiments demonstrate...