A5100398614- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Spaceflight effects on biology
- Machine Learning and Algorithms
- Optimization and Search Problems
- Diet and metabolism studies
- Single-cell and spatial transcriptomics
- Ferroptosis and cancer prognosis
- Mechanical Circulatory Support Devices
- Nitric Oxide and Endothelin Effects
- Birth, Development, and Health
- Cardiac Structural Anomalies and Repair
- Cerebrospinal fluid and hydrocephalus
- Acupuncture Treatment Research Studies
- Magnetic and Electromagnetic Effects
- Plant and Biological Electrophysiology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemical and Pharmacological Studies
- Cardiovascular Function and Risk Factors
- Machine Learning and ELM
- Cardiovascular Health and Risk Factors
- Cancer-related cognitive impairment studies
- Viral Infections and Vectors
- Magnesium in Health and Disease
Shanghai Jiao Tong University
2014-2025
Shanghai Sixth People's Hospital
2021-2025
University of Zurich
2024-2025
Jilin Agricultural University
2025
Renji Hospital
2022-2024
State Key Laboratory of Oncogene and Related Genes
2023-2024
Shanghai Cancer Institute
2023-2024
Tianjin University of Technology and Education
2024
Jiangmen Wuyi Traditional Chinese Medicine Hospital
2024
Jinan University
2024
Resistance to targeted therapy and immunotherapy in non-small cell lung cancer (NSCLC) is a significant challenge the treatment of this disease. The mechanisms resistance are multifactorial include molecular target alterations activation alternative pathways, tumor heterogeneity microenvironment change, immune evasion, immunosuppression. Promising strategies for overcoming development combination therapies, understanding better use novel drug targets, identification biomarkers, modulation so...
Abstract The immune‐inflammatory responses in the brain represent a key therapeutic target to ameliorate injury following intracerebral hemorrhage (ICH), where pro‐inflammatory microglia and its mitochondrial dysfunction plays pivotal role. Mitochondrial transplantation is promising strategy improve cellular function thus modulate their immune properties. However, of naked mitochondria into has been constrained by peripheral clearance difficulty achieving selective access brain. Here, novel...
Abstract Background and Aims Cardiogenic shock (CS) remains the primary cause of in-hospital death after acute coronary syndromes (ACS), with its plateauing mortality rates approaching 50%. To test novel interventions, personalized risk prediction is essential. The ORBI (Observatoire Régional Breton sur l’Infarctus) score represents first-of-its-kind to predict CS in ACS patients undergoing percutaneous intervention (PCI). However, sex-specific performance unknown, refined strategies are...
Exposure to microgravity leads alterations in multiple systems, but microgravity-related changes the gastrointestinal tract and its clinical significance have not been well studied. We used hindlimb unloading (HU) mouse model simulate a condition investigated intestinal microbiota colonic epithelial cells. Compared with ground-based controls (Ctrls), HU affected fecal composition profile that was characterized by expansion of Firmicutes decrease Bacteroidetes. The colon epithelium mice...
Abstract Background Although previous studies have demonstrated that the hippocampus plays a role in verbal memory, of hippocampal subfields visual memory is uncertain, especially those with preclinical Alzheimer's disease (AD). This study aimed to examine relationships between subfield volumes and SCD (subjective cognitive decline) aMCI (amnestic mild impairment). Methods The sample included 47 patients, 62 51 normal controls (NCs) was recruited from Shanghai Jiao Tong University Affiliated...
Exposure to space environment induces alterations in glucose and lipid metabolism that contribute muscular atrophy, bone loss, cardiovascular disorders. Intestinal microbiota is also changed, but its impact on spaceflight-related metabolic disorder not clear. We investigated the relationship between changes gut dysbiosis a hind limb-unloading (HU) mouse model, well-accepted ground-based spaceflight analog. Impaired body weight gain, intolerance, peripheral insulin resistance were found...
Doxorubicin (DOX) is a potent chemotherapeutic drug used for treating various cancers. However, its clinical use limited due to severe cardiotoxicity, which often results in high mortality rates. Sheng-Mai-Yin (SMY), Traditional Chinese medicine (TCM) prescription, has been reported exert cardioprotective effect cardiovascular diseases, including DOX-induced cardiotoxicity (DIC). This study aimed provide novel insights into the underlying mechanism of SMY. SMY, composed Codonopsis pilosula...
Abstract The effect of sea buckthorn seed oil (SSO) on exercise‐induced fatigue in mice was explored. animals were randomly divided into a normal control group, group (EFG), SSO low‐dose medium‐dose and high‐dose group. all the groups underwent swimming training for 10 days. Those treatment received different amounts (0.85, 1.68, 3.35 g/kg BW [body weight]) before exercise. All sacrificed last day after an exhaustive test, serum, liver, brain specimens collected. In durations SSO‐treated...
Plasma amyloid-β (Aβ) was associated with brain Aβ deposition and Alzheimer's disease (AD) development. However, changes of plasma over the course cognitive decline in continuum remained uncertain. We recruited 449 participants to this study, including normal controls (NC), subjective (SCD), mild impairment (MCI), AD, non-AD dementia. All underwent Aβ42, Aβ40, t-tau measurements single-molecule array (Simoa) immunoassay PET scan 18F-florbetapir amyloid tracer. In subgroup Aβ-PET positive,...
The liver is an essential multifunctional organ and constantly communicates with nearly all the tissues in body. Spaceflight or simulated microgravity has a significant impact on livers of rodent models, including lipid accumulation inflammatory cell infiltration. Whether similar lipotoxicity could occur humans not known, even though altered circulating cholesterol profile been reported astronauts. Using 42-day head-down bed rest (HDBR) model rhesus macaques, present study investigated...
Trigeminal neuralgia (TN), one of the most severe and debilitating chronic pain conditions, is often accompanied by mood disorders, such as anxiety depression. Electroacupuncture (EA) a characteristic therapy Traditional Chinese Medicine with analgesic anxiolytic effects. This study aimed to investigate whether EA ameliorates abnormal TN orofacial anxiety-like behavior altering synaptic plasticity in hippocampus CA1. A mouse infraorbital nerve transection model (pT-ION) neuropathic was...
Conflicting findings exist regarding the differences in amyloid burden and cognitive performance based on sex apolipoprotein E (APOE) genotype. This study aimed to investigate brain amyloid-β (Aβ) performances by APOE genotype a cohort of Aβ-positron emission tomography (PET)-positive participants. Brain Aβ was assessed using 18F-florbetapir PET standard uptake value ratios. Cognitive evaluated standardized neuropsychological tests. In cognitively normal participants, females had higher than...
ABSTRACT Background: Myocardial infarction (MI) is a common cardiovascular disease with high fatality rate once accompanied by cardiogenic shock. The efficacy of extracorporeal membrane oxygenation (ECMO) in treating MI controversial. Methods: was induced ligating the left anterior descending artery (LAD) adult male rats. Groups were defined as follows: group, reperfusion for 90 min after 30 LAD occlusion; + ECMO and performed immediately prolonged used occlusion persistent an additional...
BACKGROUND: Calcium deficiency in women is strongly linked to an increased risk of developing preeclampsia. Mitochondrial calcium ([Ca 2+ ] m ) homeostasis essential regulate vascular smooth muscle cell (VSMC) function. However, the role [Ca preeclampsia development remains largely unknown. METHODS: To investigate this, human spiral arteries obtained from normotensive and preeclamptic were collected for function, RNA sequencing, VSMC studies. N(ω)-nitro-L-arginine methyl ester–induced animal...
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of middle-aged to old individuals. The pathophysiological process AD believed begin many years before the emergence clinical symptoms. important influence congenital genetic aberrations on development provides novel opportunity initiate prenatal early postnatal pharmacological treatment address role this critical period brain in disease. Methods We investigated for first time effect oral during with...
Abstract Identifying spatially variable genes (SVGs) is crucial for understanding the spatiotemporal characteristics of diseases and tissue structures, posing a distinctive challenge in spatial transcriptomics research. We propose HEARTSVG, distribution-free, test-based method fast accurately identifying large-scale transcriptomic data. Extensive simulations demonstrate that HEARTSVG outperforms state-of-the-art methods with higher F 1 scores (average score=0.903), improved computational...