A5075457501- Cholinesterase and Neurodegenerative Diseases
- Disaster Management and Resilience
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Ecology and Vegetation Dynamics Studies
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Renal Diseases and Glomerulopathies
- Diet and metabolism studies
- Treatment of Major Depression
- Regional resilience and development
- Memory and Neural Mechanisms
- Plant and animal studies
- Climate Change, Adaptation, Migration
- Bipolar Disorder and Treatment
- Community Development and Social Impact
- Lymphatic System and Diseases
- Viral Infections and Vectors
- Angiogenesis and VEGF in Cancer
- Chronic Kidney Disease and Diabetes
- Chemical synthesis and alkaloids
- Lipid metabolism and disorders
- Alzheimer's disease research and treatments
- Advanced Glycation End Products research
- Q Methodology Applications
The University of Western Australia
2016-2022
RMIT University
2018
Botanic Gardens and Parks Authority
2016
Northumbria University
2016
Alzheimer’s Disease Neuroimaging Initiative
2015
University of Pittsburgh
2015
Providence Hospital
2015
University College London
2015
Ixico (United Kingdom)
2015
Brigham and Women's Hospital
2015
We investigated an outbreak of leptospirosis among athletes and community residents after a triathlon was held in Springfield, Illinois. A telephone survey conducted to collect clinical information data on possible risk factors, surveillance established, animal specimens lake water samples were collected determine the source leptospiral contamination. total 834 876 triathletes contacted; 98 (12%) reported being ill. Serum obtained from 474 tested; 52 these (11%) tested positive for...
Patients with Alzheimer's disease and nondemented elderly control subjects participated in studies of cortisol secretion during sleep at 9:00 a.m. were given dexamethasone suppression tests (DSTs) lumbar punctures. Nocturnal concentrations significantly higher the demented patients. CSF MHPG negatively correlated mean nocturnal cortisol. The most severely patients had highest concentrations. DST results did not distinguish samples substantially different These suggest that measurements basal...
Twelve patients with Alzheimer's disease received 0.0, 0.5, 1.0, 1.5, and 2.0 mg of oral physostigmine every 2 hours for 3-5 days; symptoms after each dose were assessed the Disease Assessment Scale. Placebo associated least severe then readministered days each. Of 10 who completed study, three showed clinically significant improvement on highest in both phases, four more marginally improved had inconsistent responses to physostigmine. Cortisol measures obtained during a sleep study suggest...
Angiopoietin-2 (Ang-2) modulates embryonic vascular differentiation primarily by inhibiting the antiapoptotic effects of Ang-1 on endothelia that express Tie-2 receptor. Ang-2 is transiently expressed developing glomeruli but downregulated with normal maturation. Glomerular expression is, however, markedly upregulated in animal models diabetic nephropathy and glomerulonephritis, both leading causes human chronic renal disease, affecting 10% world population. It was hypothesized might have...
Abstract Demand for restoration of resilient, self‐sustaining, and biodiverse natural ecosystems as a conservation measure is increasing globally; however, efforts frequently fail to meet standards appropriate this objective. Achieving these requires management underpinned by input from diverse scientific disciplines including ecology, biotechnology, engineering, soil science, ecophysiology, genetics. Despite research activity, gap between the immediate needs practitioners outputs science...
The authors examined the effects of age on plasma cortisol concentrations 81 depressed men after dexamethasone administration. Dexamethasone nonsuppression was significantly more frequent in patients older than 55 those younger. Similarly, had higher postdexamethasone younger at all time points sampled. These differences could not be attributed to severity or prevalence psychosis and patients.
The authors performed dexamethasone suppression tests (DST), TRH infusions, 72-hour urine collections, and lumbar punctures on a group of male depressed patients. Approximately 60% the patients were DST positive 33% had blunted TSH response. Two biologic variables, 8 a.m. postdexamethasone cortisol postprobenecid CSF 5-hydroxyindoleacetic acid (5-HIAA), accounted for over half variance in behavioral measure, Hamilton score. Plasma elevation was associated with high 3-methoxy-4-hydroxyphenyl...
The severe diabetic nephropathy that develops in the hypertensive transgenic (mRen-2)27 rat with streptozotocin (STZ) diabetes has previously been considered angiotensin II-dependent. Because metabolic pathways are also activated kidney, present study aimed to determine whether renoprotection could be afforded inhibitors of advanced glycation end products (AGEs), ALT-946, and aminoguanidine (AG). At 6 weeks age, nondiabetic control STZ Ren-2 rats were randomized receive vehicle, ALT-946 (1...
Cholinergic neurotransmission has long been implicated in the development of depression. In this study seven patients with Alzheimer's disease were given oral oxotremorine, a long-acting cholinergic agonist, to assess drug's effects on cognitive function. There unexpected depressive reactions five patients; three dropped out because side effects. Cardiovascular drug negligible, but its effect memory and cognition remains unknown small number subjects who completed study.
Lithium has been reported to raise serum calcium and lower phosphate concentrations increase urinary excretion. Because these changes may be effects of parathyroid hormone (PTH), PTH was measured in 19 patients receiving lithium. significantly higher than 150 normal subjects. For all correlated with lithium concentrations. These results indicate that cause biochemical hyperparathyroidism. Secondary hyperparathyroidism certain nephrotoxicity is also possible.
The rapid expansion of urban areas worldwide is leading to native habitat loss and ecosystem fragmentation degradation. Although the study urbanisation’s impact on biodiversity gaining increasing interest globally, there still a disconnect between research recommendations urbanisation strategies. Expansion Perth metropolitan area Swan Coastal Plain in south-western Australia, one world’s thirty-six hotspots, continues affect Banksia Woodlands (BWs) ecosystem, federally listed Threatened...
The authors examined the effects of certain nonpsychiatric variables on dexamethasone suppression test (DST) results. Sixty physically healthy, nondepressed, nondemented adults participated in a standard outpatient 1-mg DST. Postdexamethasone plasma cortisol concentrations were higher older subjects and lower more obese subjects. conclude that age relative weight influence healthy
Abstract The Mid-Term Review of the Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR) recognizes “interconnections and interdependencies” disaster resilience. Conceptual empirical research suggests that field currently lacks innovative methodologies to enhance associated policy practice actively harnesses these relational dimensions. To help address gaps, we apply Paul Ricœur’s concept being in world (“Oneself as Another”) explore what a relationally-focused understanding might...
Angiotensin II plays a pivotal role in the development of diabetic nephropathy, but it remains controversial as to best approach effectively block actions this hormone kidney. The aim present study was explore effects long-term treatment (8 months) with combination an angiotensin type 1 (AT1) receptor antagonist, irbesartan (15 mg/kg per day), and angiotensin-converting enzyme (ACE) inhibitor, captopril (100 spontaneously hypertensive rats. Captopril reduced blood pressure (163+/-3 mmHg...
CSF homovanillic acid levels showed a significant negative correlation with ventricle-brain ratios (VBRs) in group of drug-free chronic schizophrenic male veterans, while 5-hydroxyindoleacetic similar, nearly trend. The response plasma human growth hormone to 0.75 mg apomorphine also demonstrated VBR this group, but other measures central neurotransmitter activity were unrelated ventricular size.
The clinical correlates of hypothalamic-pituitary-adrenal (HPA) functioning were examined in 29 patients with probable Alzheimer's disease. 8:00 a.m. postdexamethasone cortisol levels these highly correlated higher agitation scores but not the degree depressed mood or memory impairment. possible neural basis for association between hypercortisolism and behavioral disturbance disease warrants further exploration replication.
Abstract Background and Aims Many terrestrial orchids have an obligate dependence on their mycorrhizal associations for nutrient acquisition, particularly during germination early seedling growth. Though important in plant growth development, phosphorus (P) nutrition studies mixotrophic been limited to only a few orchid species fungal symbionts. For the first time, we demonstrate role of range fungi acquisition transport inorganic P four phylogenetically distinct green-leaved (Diuris...
Engedal K, Davis B, Richarz U, Han J, Schäuble Andreasen N. Two galantamine titration regimens in patients switched from donepezil.Acta Neurol Scand: 2012: 126: 37–44.© 2011 John Wiley & Sons A/S. Objectives – In addition to inhibiting acetylcholinesterase, has allosteric-modulating activity at nicotinic receptors. This may make an attractive option for starting treatment Alzheimer's disease (AD), but also those who have not benefited their current therapy. study explored outcomes subjects...
Purpose – Holistic approaches to public health such as “One Health” emphasize the interconnectedness between people, animals, ecosystems, and epidemic risk, many advocate for this philosophy be adopted within disaster risk management (DRM). Historically, animal human diseases have been managed separately from each other, apart other hazards considered DRM. Shifts in DRM, however, may complement a One Health approach. The taxonomy of under DRM has expanded include medical social crises...