A5030845942- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Occupational and environmental lung diseases
- Systemic Sclerosis and Related Diseases
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Intensive Care Unit Cognitive Disorders
- Gastroesophageal reflux and treatments
- Respiratory and Cough-Related Research
- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- Sleep and related disorders
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Dysphagia Assessment and Management
- Occupational exposure and asthma
- Inflammatory Myopathies and Dermatomyositis
- Congenital Heart Disease Studies
- Delphi Technique in Research
- Medical Device Sterilization and Disinfection
- Infective Endocarditis Diagnosis and Management
- Myasthenia Gravis and Thymoma
- Marine Sponges and Natural Products
Royal Brisbane and Women's Hospital
2016-2025
The University of Queensland
2020-2025
Royal Prince Alfred Hospital
2021
Royal Brisbane and Women's Hospital Foundation
2016
Redcliffe Hospital
2016
The University of Melbourne
2013
Royal Brompton Hospital
2011-2013
Lung Institute
2013
Austin Health
2013
National Health Service
2013
In therapeutic studies in idiopathic pulmonary fibrosis (IPF), the low prevalence of significant change functional tests (PFTs) has been a major constraint. The prognostic value "marginal" changes PFTs IPF and fibrotic non-specific interstitial pneumonia (NSIP) was evaluated. patients with biopsy-proven (n = 84) NSIP 72), forced vital capacity (FVC) diffusing lung for carbon monoxide (D( L,CO)) trends at 6 months were categorised as "significant" (FVC >10%; D(L,CO) >15%) or 5-10%; 7.5-15%)....
Objective. Biomarkers of progression interstitial lung disease (ILD) are needed to allow early therapeutic intervention in patients with scleroderma-associated (SSc-ILD). Methods. A panel 8 serum cytokines [interleukin 6 (IL-6), IL-8, IL-10, CCL2, CXCL10, vascular endothelial growth factor, fibroblast factor 2, and CX3CL1] was assessed by Luminex bead technology exploratory cohorts 74 SSc 58 idiopathic pulmonary fibrosis (IPF). Mortality significant function decline [forced vital capacity...
The prevalence of idiopathic pulmonary fibrosis (IPF), a fatal and progressive lung disease, is estimated at 1.25–63 out 100 000, making large population studies difficult. Recently, the need for longitudinal registries to study IPF has been recognised. Australian Registry (AIPFR) national registry collating comprehensive data patients across Australia. We explored characteristics this cohort effect demographic physiological parameters specific management on mortality. Participants in AIPFR...
Rationale: Reliable outcome prediction in patients with fibrotic lung disease using baseline high-resolution computed tomography (HRCT) data remains challenging. Objectives: To evaluate the prognostic accuracy of a deep learning algorithm (SOFIA [Systematic Objective Fibrotic Imaging Analysis Algorithm]), trained and validated identification usual interstitial pneumonia (UIP)-like features on HRCT (UIP probability), large cohort well-characterized progressive drawn from national registry....
In idiopathic interstitial pneumonia (IIP), the significance of connective tissue disease (CTD) features in absence a specific CTD diagnosis remains unclear. We studied clinical and prognostic utility undifferentiated (UCTD) patients with biopsy-proven IIP. IIP undergoing surgical lung biopsy (1979-2005) were (nonspecific (NSIP), n = 45; pulmonary fibrosis, 56). UCTD was considered present when serum autoantibodies symptoms or signs suggested CTD. The relationship between NSIP histology...
Studies analysing the effect of worsening pulmonary physiological impairment in idiopathic fibrosis (IPF) with respect to quality life have been limited single centres or highly selected trial populations. The aim this study was determine principal determinants baseline and longitudinal health-related (HRQoL) a large unselected IPF population.We used Australian Registry examine relationship between HRQoL, measured using St George Respiratory Questionnaire (SGRQ), demographic features,...
Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease in which circulatory biomarkers have the potential for guiding management clinical practice. We assessed prognostic role of serum three independent IPF cohorts: Australian Pulmonary Fibrosis Registry (AIPFR), Trent Lung (TLF) and Prospective Observation Clinical Endpoints (PROFILE). Methods In AIPFR cohort, candidate proteins were by ELISA as well an unbiased proteomic approach. LASSO (least absolute shrinkage...
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal fibrosing lung disease of unknown cause. The advent anti-fibrotic medications known to slow progression has revolutionised IPF management in recent years. However, little about the natural history patients with mild physiological impairment. We aimed assess these using data from Australian Registry (AIPFR). Using our cohort real-world patients, we compared FVC criteria for impairment (FVC ≥ 80%) against other proposed criteria:...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with poor prognosis. Antifibrotics slow the decline of function after 12-months, but limited studies have examined role circulatory biomarkers in antifibrotic treated IPF patients. Serum from 98 participants, Australian Pulmonary Fibrosis Registry were collected at four time-points over 1 year post-antifibrotic treatment and analysed as two separate cohorts. Patients stratified progressive, if they experienced ≥ 10%...
Gastroesophageal reflux disease (GORD) is highly prevalent in idiopathic pulmonary fibrosis (IPF) and may play a role its pathogenesis. Recent IPF treatment guidelines suggest that all patients with be considered for antacid therapy. However, emerging evidence suggests therapy does not improve patient outcomes increase the risk of infection. Using prospectively collected data from Australian Registry including use therapy, GORD diagnosis symptoms, relationship these variables to survival...
ABSTRACT Background and objective Current guidelines for the diagnosis of idiopathic pulmonary fibrosis (IPF) provide specific criteria in setting multidisciplinary discussion (MDD). We evaluate utility reproducibility these diagnostic guidelines, using clinical data from Australian IPF Registry. Methods All patients enrolled registry undergo a review whereby international are applied via MDD. investigated applicability with regard to: (i) adherence to (ii) Natural history categories (iii)...
Abstract Background and objective Idiopathic pulmonary fibrosis (IPF) is one of the most common forms interstitial lung diseases. While studies have been conducted in other countries to determine epidemiological burden IPF, there limited information Australia. Our study aimed address this gap generate first estimates for mortality, incidence prevalence IPF Methods Estimates were generated by utilizing novel Mortality Incidence Analysis Model (MIAMOD) method software based on illness–death...
Sleep deprivation is a contributor for delirium in intensive care. Melatonin has been proposed as pharmacological strategy to improve sleep, but studies have shown that the increase plasma levels of melatonin do not correlate beneficial clinical effect; addition, melatonin's short half-life may be major limitation achieving therapeutic levels. This study applies previously published novel regimen with proven sustained during 12 h period. In this study, aim determine if such dosing positively...
The difference in patient comfort with conscious sedation versus general anaesthesia for bronchoscopy has not been adequately assessed a randomised trial. This study aimed to assess if during is noninferior anaesthesia.96 subjects were receive or bronchoscopy. primary outcome was subject comfort. Secondary outcomes included willingness undergo repeat procedure necessary and level of clinically by bispectral index (BIS) monitoring.There no significant between scores (difference -0.01, 95% CI...
Using nasopharyngeal (NP) swab samples instead of lower respiratory tract specimens for polymerase chain reaction (PCR) to diagnose
The mucolytic, anticoagulative, anti-inflammatory and neo-angiogenic properties of inhaled heparin may benefit patients with burns cystic fibrosis. We assessed the antibacterial effects unfractionated heparin.Stored clinical isolates Acinetobacter baumannii (n =4), Candida albicans = 5), Haemophilus influenzae =5), Klebsiella pneumoniae methicillin-resistant Staphylococcus aureus (n=3), Pseudomonas aeruginosa 2), Streptococcus 7) were subcultured on horse blood agar, incubated at 35 degrees...