A5035887328- Air Quality and Health Impacts
- Nanoparticles: synthesis and applications
- Animal testing and alternatives
- SARS-CoV-2 and COVID-19 Research
- Climate Change and Health Impacts
- Sinusitis and nasal conditions
- Inhalation and Respiratory Drug Delivery
- COVID-19 diagnosis using AI
- Infection Control and Ventilation
- Respiratory viral infections research
Unit of Functional and Adaptive Biology
2023-2024
Université Paris Cité
2023-2024
Agence de la transition écologique
2023-2024
Centre National de la Recherche Scientifique
2023
The COVID-19 pandemic was marked by successive waves of SARS-CoV-2 variants with distinct properties. Omicron variant that emerged in late 2021 showed a major antigenic shift and rapidly spread worldwide. Since then, Omicron-derived have maintained their global dominance, for reasons remain incompletely understood. We report the original BA.1 evolved several traits converged facilitating viral spread. First, displayed an early replicative advantage over previous when grown reconstructed...
<title>Abstract</title> The use of animals in chemical testing and hazard assessment can be reduced using New Approach Methods or NAMs. In vitro human models have been successfully developed to measure the acute toxicity drugs environmental pollutants. this study, we introduce 3D model bronchial epithelium assess repeated exposure xenobiotics. lung epithelial cell line Calu-3 was exposed silver nanoparticles at air-liquid interface every 2 3 days during 12 mimic inhaled particles. biological...
Abstract Epidemiological studies have shown an association between exposure to fine particles (PM2.5) and the severity of respiratory infections such as influenza COVID-19. PM2.5 viruses target bronchial epithelium suggesting that could make it more susceptible infections. Our project aims study impact on virus decipher underlying mechanisms. We used a human grown at air-liquid interface (ALI) characterised its responses single 24h ALI 5, 10 or 20 µg/cm². Particles induced expression...
Abstract During air pollution peaks, influenza infections are more severe, and the number of hospitalizations associated to flu increases. This project aims study if contributes severity infection. To this end, mice were intratracheally exposed once well-characterized particulate matter collected from Paris atmosphere (PM2.5) inflammation was determined in broncho-alveolar lavages (BALs) at different time points post-exposure. We observed that 2 mg/kg PM2.5 induced recruitment neutrophils...