A5091056258- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Adrenal and Paraganglionic Tumors
University of Pennsylvania
2010-2024
We define a subset of macrophages in the tumor microenvironment characterized by high intracellular iron and enrichment heme metabolism genes. These iron-rich tumor-associated (iTAMs) supported angiogenesis immunosuppression were conserved between mice humans. iTAMs comprise two additional subsets based on gene expression profile location—perivascular (pviTAM) stromal (stiTAM). identified endothelin receptor type B (Ednrb) as specific marker found myeloid-specific deletion Ednrb to reduce...
Hypoxia is known to play important role in cancer biology. In sarcomas, hypoxia-induced protein biomarkers such as Inducible Factor-1a (HIF-1a), vascular endothelial growth factor (VEGF), and Erythropoietin (Epo) have been previously reported only a few studies. Moreover, the biologic significance relationship tumorigenesis of these not well understood context sarcoma. The HIF negative regulator, Prolyl Hydroxylase Domain 2 (PHD2) has evaluated sarcomas. We examined expression PHD2, HIF-1a,...
Context: Currently, there is no effective treatment for iodine-resistant thyroid cancers. Objective: As a new approach to treatment, the efficacy of replication-selective, human thyroglobulin (TG) enhancer and promoter-driven, adenovirus (AdhTGEP)-mediated oncolysis was investigated using two well-differentiated cancer cell lines, XTC (TG positive) FTC-133 negative), other control tumor nontumor lines (all TG negative). Design: A cohort study design used. Setting: The setting laboratory...