A5100399635- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Carbohydrate Chemistry and Synthesis
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Cardiac Health and Mental Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Hemoglobin structure and function
- Cancer Immunotherapy and Biomarkers
- Surfactants and Colloidal Systems
- FOXO transcription factor regulation
- Spaceflight effects on biology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ubiquitin and proteasome pathways
- Protein Interaction Studies and Fluorescence Analysis
- RNA and protein synthesis mechanisms
- Research Data Management Practices
- Diabetes Management and Education
- Cell Image Analysis Techniques
- Polysaccharides and Plant Cell Walls
Chengdu Medical College
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
George Washington University
2023-2025
Peking Union Medical College Hospital
2025
Jinzhou Medical University
2012-2024
Weatherford College
2024
University of Florida
2024
Okayama University
2023
Affiliated Hospital of Nantong University
2023
Nantong University
2022-2023
The Playbook Workflow Builder (PWB) is a web-based platform to dynamically construct and execute bioinformatics workflows by utilizing growing network of input datasets, semantically annotated API endpoints, data visualization tools contributed an ecosystem collaborators. Via user-friendly user interface, can be constructed from building-blocks without technical expertise. output each step the workflow added into reports containing textual descriptions, figures, tables, references. To...
Hepatocellular carcinoma (HCC) is a major global cause of death, with epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC)-like properties contributing to its metastasis. DEAD box helicase 56 (DDX56) involved in carcinogenesis, but role EMT induction phenotype maintenance unclear. This study assessed the impact DDX56 absence on HCC stemness EMT. was found be overexpressed tissues, correlating disease stage prognosis.
This study aimed to examine the correlation between Ki‐67 expression and clinicopathological features of oral oropharyngeal squamous cell carcinoma (OSCC/OPSCC), evaluate prognostic value Ki‐67, develop a model incorporating expression. A total 469 patients diagnosed with OSCC/OPSCC, hospitalized 2012 2022, were included. Patients’ surgical specimens subjected immunohistochemical staining determine their Clinicopathological data also collected. Patients exhibiting male sex, poor pathological...
The downregulation of SPRED2, a negative regulator the ERK1/2 pathway, was previously detected in human cancers; however, biological consequence remains unknown. Here, we investigated effects SPRED2 loss on hepatocellular carcinoma (HCC) cell function. Human HCC lines, expressing various levels and knockdown, increased activation. SPRED2-knockout (KO)-HepG2 cells displayed an elongated spindle shape with migration/invasion cadherin switching, features epithelial-mesenchymal transition (EMT)....
Yijie Tang, Tianyi Wang, Anping Zhang, Jiaqi Zhu, Tingting Zhou, You-Lang Jiahai Shi
Circular RNAs (circRNAs) are linked to the regulation of sepsis-induced acute kidney injury (AKI). However, function circITCH in development AKI is still unclear. The levels circITCH, miR-579-3p and ZEB2 were examined by real-time PCR immunoblotting. Then, roles cell viability, apoptosis, inflammation lipopolysaccharide (LPS)-treated HK-2 cells evaluated. further mechanism was investigated using rescue assays. CircITCH downregulated septic patients LPS-triggered cells. overexpression...
Hepatocellular carcinoma (HCC) is one of the most common cancers globally, seriously endangering people health. Vitamin D was significantly associated with tumor progression and patients’ prognosis. Integrative 10 machine learning algorithms were used to develop a D-related signature (VRS) training cohort 3 testing cohorts. The performance VRS in predicting immunology response verified using several approaches. optimal constructed by stepCox + superPC algorithm. acted as risk factor for HCC...
Breast cancer (BC) is one of the most common malignant tumors in women, and screening relevant genes markers that are involved BC tumor genesis progression great value. We previously found messenger RNA expression ARHGAP9 was high tissue, but it unclear whether participates human BC. In this study, we correlated with poor patient survival, American Joint Committee on Cancer clinical staging, size, differentiation. MCF-7 MDA-MB-231 cells exhibited higher than other cell lines (HCC1937,...
Epithelial cell transforming sequence 2 (ECT2) is a guanine nucleotide exchange factor encoded by the ECT2 gene, which located on 3q26.31 chromosomal region and directly associated with occurrence of cancers. The aim present study was to examine expression prognostic importance in various breast cancer subtypes using online tools, Gene Expression Profiling Interactive Analysis, Kaplan-Meier-plotter bc-GenExMiner. mRNA significantly different oestrogen receptor ER(+) cancer; overexpression...
Ecotropic viral integration site‑1 (EVI‑1) is an important transcription factor involved in oncogenesis. Aberrant EVI‑1 expression has been reported to be a characteristic of multiple types malignancies; however, very little known about how regulates breast cancer. Current knowledge target genes mediate the biological function remains limited. In present study, overexpression promoted cell proliferation, migration, and invasion, inhibited apoptosis By contrast, silencing migration enhanced...
Abstract Recent technological advances in glycobiology have resulted a large influx of data and the publication many papers describing discoveries glycoscience. However, terms used glycan structural features are not standardized, making it difficult to harmonize across biomolecular databases, hampering harvesting information studies hindering text mining curation efforts. To address this shortcoming, Glycan Structure Dictionary has been developed as reference dictionary provide standardized...
Raf kinase inhibitor protein (RKIP) is recognized as a suppressor of metastasis, and the downregulation RKIP associated with aggressive events poor outcome in variety solid tumors. However, clinical relevance expression tongue squamous cell carcinoma (TSCC) remains unclear. In present study, 85 pairs TSCC corresponding adjacent non-cancerous tissues, 30 matched metastatic lesions from cervical lymph nodes 32 oral leukoplakia samples were assessed using immunohistochemical methods. The...
Diabetes is a common global disease closely associated with an increased risk of depression. This study analyzed China Health and Retirement Longitudinal Study (CHARLS) data to examine depression in diabetic patients across China. using 29 variables including demographic, behavioral, health conditions, mental parameters. The dataset was randomly divided into 70% training set 30% validation set. Predictive factors significantly were identified least absolute shrinkage selection operator...