A5087086476- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Crystallography and molecular interactions
- Radical Photochemical Reactions
- Peptidase Inhibition and Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- Protein Degradation and Inhibitors
- Chemical Synthesis and Reactions
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Catalytic Alkyne Reactions
- Click Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- Sulfur-Based Synthesis Techniques
- Advanced MRI Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Process Optimization and Integration
- Synthetic Organic Chemistry Methods
- Fluorine in Organic Chemistry
- Advanced NMR Techniques and Applications
- CO2 Reduction Techniques and Catalysts
- Advanced battery technologies research
AstraZeneca (Sweden)
2023-2024
Roche (Switzerland)
2023
Robert Bosch (Germany)
2021
University of Manchester
2016-2020
Silesian University of Technology
2017
2D NMR is an immensely powerful structural tool but it time-consuming. Targeting individual chemical groups by selective excitation in a 1D experiment can give the information required far more quickly. A major problem, however, that proton spectra are often extensively overlapped, so practice only minority of sites be selectively excited. Here we overcome problem using fast, single-scan method allows signals single multiplet even where severely overlapped other multiplets. The advantages...
Precise length, shape, and linker attachment points are all integral components to designing efficacious proteolysis targeting chimeras (PROTACs). Due the synthetic complexity of these heterobifunctional degraders difficulty computational modeling aid PROTAC design, exploration structure–activity relationships remains mostly empirical, which requires a significant investment time resources. To facilitate rapid hit finding, we developed capabilities for parallel synthesis purification by...
Facile access to sp3-rich scaffolds containing a sulfonyl fluoride group is still limited. Herein, we describe mild and scalable strategy for the preparation of alkyl fluorides from readily available bromides alcohols using photoredox catalysis. This approach based on halogen atom transfer (XAT), followed by SO2 capture fluorination. The method features conditions enabling fast high-value derivatives has been scaled up 5 g continuous stirred tank reactor cascade.
The expedient assembly of complex, natural product-like small molecules can deliver new chemical entities with the potential to interact biological systems and inspire development drugs probes for biology. Diversity-oriented synthesis is a particularly attractive strategy delivery complex in which 3-dimensional architecture varies across collection. Here we describe folding cascade approach polycyclic bearing multiple stereocentres mediated by reductive single electron transfer (SET) from...
A selective coupling of allyl/propargyl ethers and δ-ketoesters, mediated by SmCp<sup>R</sup><sub>2</sub>, delivers δ-lactones, or complex cycloheptanols <italic>via</italic> a telescoped approach.
Precise linker length, shape and attachment point are all integral components to designing efficacious PROTACs. Due the increased synthetic complexity of these heterobifunctional degraders difficulty computational modelling aid PROTAC design, exploration structure-activity-relationship (SAR) remains mostly empirical, which requires a significant time resource investment. To facilitate rapid hit finding we developed capabilities for parallel synthesis purification by harnessing an array...
Dalcetrapib (1), a cholesterol ester transfer protein inhibitor, was clinical candidate at Roche until 2012. By this time, manufacturing processes capable of efficiently delivering kilotonne annual volumes had been developed and demonstrated the commercial scale. This paper describes development synthetic routes for manufacture key intermediate 1-(2-ethylbutyl)-cyclohexanecarboxylic acid (2) selection preferred process. The selected process involves novel methods α-alkylation nitrile using...
Synthesis and bioactivity of guanidinium-functionalized pillar[5]arene are reported by Ruibing Wang et al. in their Communication on page 618. Metal-Organic FrameworksConfigurational entropy is revealed to play an important role the pressure induced phase transition apillared-layer metal-organic framework, as Rochus Schmid, Gregor Kieslich Research Article 787. InhibitorsIn 813, Fredrik Ekstrçm co-workers describe for eries arylvinylpyridinium-based compounds previously believed be...