A5022670438- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Plant-Microbe Interactions and Immunity
- Metabolomics and Mass Spectrometry Studies
- Plant Pathogenic Bacteria Studies
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Plant Parasitism and Resistance
- Traditional Chinese Medicine Analysis
- Plant Stress Responses and Tolerance
- Drug-Induced Hepatotoxicity and Protection
- Cancer Immunotherapy and Biomarkers
- Rheumatoid Arthritis Research and Therapies
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Natural Compounds in Disease Treatment
- Traditional Chinese Medicine Studies
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- Reproductive System and Pregnancy
- Plant Virus Research Studies
- Cocoa and Sweet Potato Agronomy
- Phytoplasmas and Hemiptera pathogens
- Cell Adhesion Molecules Research
- Polysaccharides and Plant Cell Walls
Anhui University of Traditional Chinese Medicine
2016-2024
Citrus Research Institute
2019-2023
Southwest University
2019-2023
Chinese Academy of Agricultural Sciences
2019-2023
First Hospital of Shijiazhuang
2014
Citrus bacterial canker (CBC) is a disease resulting from Xanthomonas citri subsp. (Xcc) infection and poses grave threat to citrus production worldwide. Wall-associated receptor-like kinases (WAKLs) are proteins with central role in resisting range of fungal diseases. The roles WAKLs the context CBC resistance, however, remain unclear. Here, we explored CsWAKL08, which confers resistance CBC, additionally analyzed molecular mechanisms CsWAKL08-mediated resistance. Based on systematic...
Abstract Citrus bacterial canker (CBC) results from Xanthomonas citri subsp. ( Xcc ) infection and poses a grave threat to citrus production. Class III peroxidases (CIII Prxs) are key proteins the environmental adaptation of plants range exogenous pathogens, but role CIII Prxs during plant resistance CBC is poorly defined. Herein, we explored CsPrx25 its contribution defenses in molecular detail. Based on expression analysis, was identified as an apoplast-localized protein that...
Citrus is one of the most important commercial fruit crops worldwide. With vast genomic data currently available for citrus fruit, genetic relationships, and molecular markers can be assessed development breeding selection strategies. In this study, to permit ease access these data, a web-based database, variation database (CitGVD, http://citgvd.cric.cn/home) was developed as first citrus-specific comprehensive dedicated genome-wide variations including single nucleotide polymorphisms (SNPs)...
Citrus bacterial canker (CBC) caused by Xanthomonas citri subsp. (Xcc) is a systemic disease that affects citrus plantations globally. Biotic stress in plants has been linked to group of important transcription factors known as Basic Leucine Zippers (BZIPs). In this study, CsBZIP40 was functionally characterized expression analysis, including induction Xcc and hormones, subcellular localization, over-expression RNAi silencing. belongs D the CsBZIP family localizes nucleus, potentially...
As the bacterial etiologic agent causing citrus canker (CBC), Xanthomonas citri subsp. (Xcc) seriously impacts plantation and fruit production globally. In an earlier study, we demonstrated that CsBZIP40 can positively impact CBC resistance in sweet orange (Citrus sinensis). However, mechanistic basis for protective benefits conferred by is yet to be delineated. Here, show regulates reactive oxygen species (ROS) homeostasis transgenic overexpressing CsBZIP40. directly binds TGA-box of...
<title>Abstract</title> This study aimed to evaluate the effectiveness of causality analysis-based predictive nursing interventions in reducing complications and improving outcomes among nasopharyngeal carcinoma (NPC) patients undergoing radiotherapy. A randomized controlled trial was conducted with 96 NPC admitted between November 2021 2023. Participants were divided into Group (routine care, n = 48) B (predictive intervention, 48). received analysis-guided targeting oral mucositis,...
Immune checkpoint blockade (ICB) therapy has transformed the treatment of triple-negative breast cancer (TNBC) in recent years. However, some TNBC patients with high programmed death-ligand 1 (PD-L1) expression levels develop immune resistance. Hence, there is an urgent need to characterize immunosuppressive tumor microenvironment and identify biomarkers construct prognostic models patient survival outcomes order understand biological mechanisms operating within microenvironment.RNA sequence...
To explore the pathogenesis of rheumatoid arthritis (RA) from perspective metabolomics, gas chromatography time-of-flight mass spectrometry (GC-TOF/MS) technology was used to observe changes in metabolic profiles urine output rats with adjuvant-induced (AA). Sprague-Dawley were randomly divided into a control group and an experimental group, eight each. Rats induced by intracutaneous innoculation 0.1 mL Freund's complete adjuvant right paws. On day 20 after immunization, between rat groups...
Type 2 diabetes mellitus (T2DM) has become a chronic disease, serious harm to human health. Complications of the blood pipe are main cause disability and death in diabetic patients, including vascular lesions that directly affects prognosis patients with survival. This study was determine influence high glucose related mechanism lesion type pathogenesis. In vivo aorta abdominalis GK rats observed pressure, heart rate, hematoxylin eosin (H&E), Masson, Verhoeff staining. vitro cells were...
The aim of the present study was to explore changes in urinary metabolic spectrum rats with knee osteoarthritis, using gas chromatography-time flight/mass spectrometry (GC-TOF/MS) determine metabonomic disease pathogenesis. Sprague-Dawley were randomly divided into control and model groups (n=8/group), 20 µl 4% papain 0.03 M L-cysteine injected right on days 1, 3 7 establish osteoarthritis model. Following 14 days, urine collected over 12 h cartilage ultrastructural damage assessed by...
Liver fibrosis is caused by liver injury induced a number of chronic diseases, including schistosome infection, hepatitis metabolic disease, alcoholism and cholestasis. The tissue damage occurring after or inflammation the reversible lesion; however, has become worldwide problem poses threat to human health. development an effective drug for prevention treatment ongoing uses information from different occurrences fibrosis. In present study, carbon tetrachloride (CCl4)‑induced metabonomic...
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology, which occurs in ~1.0% the general population. Increasing studies have suggested that long non‑coding RNAs (lncRNAs) may serve important roles various biological processes and be associated with pathogenesis different types disease, including RA. Astragalosides (AST) has been used as a traditional Chinese medicine for treatment However, mechanism underlying its therapeutic effect remained unclear to date. Thus, there...
The present study was designed to serve as a comprehensive analysis of Citrus sinensis (C. sinensis) pectin acetylesterases (CsPAEs), and assess the roles these PAEs involved in development citrus bacterial canker (CBC) caused by Xanthomonas citri subsp. (Xcc) infection. A total six CsPAEs were identified genome C. sinensis, with genes being unevenly distributed across chromosomes 3, 6, 9, unassembled scaffolds. subset found be responses Xcc In particular, CsPAE2 associated such infections,...
Context Qi Teng Xiao Zhuo granule (QTXZG) is a traditional Chinese medicine (TCM) used for therapeutic effects on chronic glomerulonephritis (CGN). However, the underlying mechanism remains unclear.Objective To investigate molecular of QTXZG CGN by proteomics.Materials and methods The model was induced in Sprague–Dawley rats injecting adriamycin (3.5 mg/kg, Day 1; 3.0 14) twice through tail vein. Urine samples were collected 21st day; divided randomly into control, adriamycin, administration...
Liver fibrosis is a common stage in the majority of chronic liver diseases, regardless etiology, and its progression may lead to hepatic cirrhosis or hepatocellular carcinoma. Metabolomics, powerful approach systems biology, discipline used qualitatively quantitatively analyze small molecule metabolites cells at specific times under certain conditions. The present study aimed investigate serum metabolic changes following Shu Gan Jian Pi formula (SGJPF) treatment carbon tetrachloride...
Abstract The aim of this study was to explore the changes in urine metabolic spectrum rats with early stage liver fibrosis using gas chromatography–time flight/mass spectrometry (GC‐TOF/MS), try search for potential biomarkers and elucidate probably metabonomic pathogenesis. established a single subcutaneous injection carbon tetrachloride twice each week 4 weeks continuously. At end experiment, GC‐TOF/MS technology multivariate statistical approaches such as principal component analysis,...
Objectives: To screen and study circular RNA (circRNA) expression profiles in QTXZG-mediated treatment of chronic glomerulonephritis (CGN) induced by adriamycin rats to research the possible roles molecular mechanisms QTXZG. Materials methods: Next-generation sequencing was used identify circRNA CGN after QTXZG compared with a model group control group. Bioinformatics analysis performed predict potential target miRNAs mRNAs. GO pathway analyses for mRNAs were explore differentially expressed...
Chronic glomerulonephritis (CGN) is one of the leading causes end-stage renal disease (ESRD). A growing body literature emphasizes important role long non-coding RNAs (lncRNAs) in development and progression disease. However, function NONRATG001910.2 CGN was not well understood. This research aimed to investigate effect on revealed its potential molecular mechanisms. In this work, expression detected by quantitative real-time polymerase chain reaction (qRT-RCR) cell lines. We found that...