We describe a rare case of developmental venous anomaly associated with an arteriovenous malformation. A 20-year-old male presented seizures and was diagnosed left parietal malformation combined in the frontal lobe, draining veins both lesions converging into same bridging vein despite affecting anatomically distinct areas. The patient underwent craniotomy for resection However, progressive aphasia developed on third postoperative day. Subsequent neuroimaging (CT MRI) revealed thrombosis...

We report a rare case of extradural spinal chondrosarcoma in 48-year-old female. The patient was asymptomatic until traumatic injury led to lumbar pain, revealing tumor with atypical imaging characteristics adjacent vertebral segments. MRI confirmed an tumor, which surgically excised. Histopathological examination identified the as myxoid chondrosarcoma. underwent extensive surgical treatment, no local recurrence or distant metastasis observed after five years. Her pain also completely...

Objective: To investigate the histopathological subtype and clinical characteristics of vascular malformations in head neck. Methods: All patients with neck referred to Henan Provincial People's Hospital between January 2021 December 2023 were collected, clinicopathological features analyzed by SPSS 26.0 statistical software. Results: A total 675 included, there 293 male 382 female a mean onset age (26.2±21.8）years diagnosis (31.8±20.6）years. Most located oral maxillofacial region (52.1%,...

To investigate the clinicopathological and molecular genetic characteristics of well-differentiated/dedifferentiated liposarcoma (WDLPS/DDLPS) with myxoid-like morphology, to distinguish them from myxofibrosarcoma (MFS) similar morphology.

Background: Spontaneous spinal epidural hematoma (SSEH) presenting in the context of JAK2 V617F-positive myeloproliferative neoplasms is a rare condition, characterized by compression cord leading to various symptoms. The etiology, pathogenesis, and optimal treatment strategies for this condition remain undetermined. occurrence spontaneous (MPNs) represents manifestation. Magnetic Resonance Imaging (MRI) plays crucial role definitive diagnosis condition. With good understanding pathogenic...

目的： 探讨肌内血管瘤毛细血管型（intramuscular hemangioma capillary type，IHCT）临床病理学特征、遗传学特征、诊断及鉴别诊断。 方法： 收集河南省人民医院2012年1月至2022年4月手术切除且明确诊断为IHCT的病例共16例，对其采用免疫组织化学法检测相关蛋白表达，荧光定量聚合酶链反应（PCR）、二代测序检测相关基因突变情况，并文献复习。 结果： 男性7例，女性9例，年龄1~36岁，平均年龄12岁。临床表现为无明显诱因发现局部肿物或受累肌肉疼痛。镜下见病变组织在骨骼肌纤维之间密集生长，边界欠清；低倍镜下可见小的圆形或弯曲的毛细血管形成团块、片状和小叶结构，小血管相互吻合形成管腔；高倍镜下显示内皮细胞肥胖，细胞形态温和，缺乏核的多形性和异型性，伴少量核分裂象，未见病理性核分裂象。8例行PIK3CA、BRAF、KRAS基因检测，均未见突变。4例行二代测序检测，1例存在MAP2K1基因突变（p.Q56P）。 结论：...

Objective: To investigate the clinicopathological features of glomuvenous malformation (GVM). Methods: Thirty-one cases GVM diagnosed at Henan Provincial People's Hospital from January 2011 to December 2021 were collected. Their clinical and pathological analyzed. The expression relevant markers was examined using immunohistochemistry. patients also followed up. Results: There 16 males 15 females in this study, with an average age 11 years (range, 1-52 years). locations disease included 13...

The ultrasonography features of alveolar soft part sarcoma (ASPS) and intramuscular capillary-type hemangiomas (ICTH) were analyzed, the diagnostic model ASPS was established.

纤维脂肪脉管异常（法瓦病）是新近报道的一种罕见且尚未被明确分类的血管异常性疾病，主要累及四肢尤其是下肢骨骼肌。目前国内外报道少见，且以临床和影像学为主，国内尚未见病理形态学方面的详细报道。本文报道1例年轻患者下肢弥漫型法瓦病，结合相关文献复习，重点描述其形态学表现及与普通静脉畸形的鉴别诊断要点，以引起病理医师对该疾病的关注，进一步提高病理诊断水平，作到病理层面的精准分类，为临床诊疗提供依据。.

To investigate the clinicopathological features, classification, and genetic characteristics of common lymphatic malformation (CLM) in superficial soft tissue.

血管瘤是由胚胎期间成血管细胞增生形成的肿瘤，国际血管瘤和脉管畸形研究学会的分类能很好的指导该疾病的临床管理，对于及时临床干预治疗和规范随访有重要意义，并且可以有效的避免诊断术语混乱。本文对常见良性血管瘤类型进行了系统的描述，对比和总结了常见良性血管瘤临床病理特征，并且详细介绍了常见良性血管瘤的诊断流程。.

The diagnosis of vascular diseases is not only about distinguishing neoplastic or non-neoplastic lesions, but also focusing more on emphasizing the essence disease, namely presence absence endothelial cell proliferation, and further to true hemangioma tumors malformation. This article based International Society for Study Vascular Anomalies (ISSVA) classification, which widely used in clinical practice, discusses related pathological issues diseases.

探讨弹力纤维和Masson染色在单纯性脉管畸形中的染色情况及其对诊断和鉴别诊断的应用价值。

目的： 探讨原发性心脏血管肉瘤（primary cardiac angiosarcoma，PCAS）临床病理及遗传学特点。 方法： 收集河南省人民医院确诊的PCAS共9例，采用免疫组织化学和二代测序技术检测蛋白和基因突变情况。 结果： 本组患者男性7例，女性2例；年龄18~53岁；6例位于右心房，2例位于心包，1例位于右房室沟。9例伴心包积液，3例伴胸腔积液，4例伴肺多发转移。细胞学见肿瘤细胞呈腺样、乳头状排列，上皮样形态，酷似腺癌细胞；组织学见肿瘤组织呈高-中等分化，见不规则血管腔样结构，瘤细胞鞋钉样或乳头状，部分区域呈片状、束状排列，细胞胖梭形，核深染不规则，异型性明显，病理性核分裂象易见；免疫标记显示肿瘤细胞强表达CD34、CD31、ERG。伴多发肺转移结节和浆膜腔积液病例存在TP53错义突变（p.R273C），且肿瘤细胞p53蛋白强阳性。 结论： PCAS早期即存在浆膜腔积液和肺多发转移，组织形态呈高-中等分化，细胞学极易误诊为腺癌，免疫组织化学有助于鉴别诊断；且TP53突变可能与肿瘤的高侵袭性生物学行为相关。.

Objective: To investigate the clinical and pathologic features, diagnosis differential of congenital hemangioma (CH). Methods: Forty cases CH were diagnosed from January 2017 to December 2020 in Henan Provincial People's Hospital. The pathological immunohistochemical data analyzed, with review literature. Results: There 24 male 16 female patients. lesions located head, neck (11 cases), limbs (14 trunk (15 cases). manifestations painless plaques or masses, larger ones protruded on skin...

目的： 探讨肺微小脑膜上皮样结节（MPMN）的临床病理特征、免疫组织化学表型及鉴别诊断。 方法： 收集解放军总医院第一医学中心及河南省人民医院病理科可明确诊断为MPMN的病例，观察总结其临床病理学特征，并进行相关文献复习。 结果： 97例患者中男性15例，女性82例，年龄30~76岁，平均59岁。97例中有77例MPMN与其他肺部肿瘤或炎性病变并存，其中3例肺浸润性腺癌累及MPMN。结节直径0.5~9.0 mm。MPMN结节数目与患者性别、年龄、是否伴随肺腺癌及部位的差异均无统计学意义（P>0.05）。镜下病变细胞为短梭形或类圆形，呈旋涡状排列，合体状，细胞形态温和，细胞核圆形或卵圆形，核仁不明显，未见核分裂象。免疫组织化学显示MPMN细胞表达波形蛋白、上皮细胞膜抗原、孕激素受体、SSTR2及CD56。65例患者获得术后随访，目前均未出现MPMN复发或转移。 结论：...

目的： 探讨婴儿性血管瘤（infantile hemangioma，IH）临床病理学特征。 方法： 搜集2013—2020年河南省人民医院病理科IH确诊病例52例，对其形态学、免疫表型及PIK3CA、GNAQ基因变异情况进行分析。 结果： 52例IH女患儿37例，男患儿15例，发病部位有四肢、躯体和头颈部。病变外观均呈鲜红色或暗红色斑块，形态学上，肿瘤组织呈分叶状生长，增殖期血管内皮细胞密集成片，呈卵圆形或上皮样形态，血管腔不明显，可见细胞凋亡；消退期血管内皮细胞较稀疏，呈纤细梭形或扁平状，血管腔可见，多量脂肪纤维组织增生。免疫组织化学结果显示血管内皮细胞表达葡萄糖转运蛋白1、CD15及其他内皮相关标志物；PIK3CA、GNAQ基因均未见突变。 结论： IH是发生于婴幼儿较常见的血管源性良性肿瘤，形态学以分叶状结构生长，伴血管内皮细胞增生及微血管腔形成为主，增殖期需与卡波西型血管内皮瘤、先天性血管瘤等鉴别，消退期需与脉管畸形等鉴别。.

目的： 探讨血管内分叶状毛细血管瘤（intravascular lobular capillary hemangioma，ILCH）临床病理学特征、诊断及鉴别诊断。 方法： 收集河南省人民医院2010年1月至2021年12月确诊的ILCH病例8例，分析临床及病理学资料，采用免疫组织化学检测相关指标，并文献复习。 结果： 8例ILCH中，男性1例，女性7例，年龄23~70岁，中位年龄31.5岁。发病部位为手指（5例）和手背（3例），7例单发，1例多发。肿物最大径0.5~3.0...

目的： 探讨发生于浅表软组织的普通静脉畸形（common venous malformation，CVM）临床病理特点及基因变异特征。 方法： 收集河南省人民医院2020年1月至11月确诊的CVM共75例，采用免疫组织化学、荧光PCR法检测相关指标情况。 结果：...

Objective: To study the clinicopathological, immunophenotypic and molecular genetic characteristics of nodular fasciitis (NF) in unusual sites. Methods: A total 50 cases NF diagnosed between January 2015 2021 were reviewed Department Pathology, Henan Provincial People's Hospital, clinical pathologic data analyzed. Among them, 14 from sites included this study. Immunohistochemical (IHC) staining was used to detect expression related proteins, fluorescence situ hybridization (FISH) breakage...

目的： 探讨葡萄酒色斑（port-wine stains，PWS）及Sturge-Weber综合征（Sturge-Weber syndrome，SWS）的分子遗传学及临床病理学特征。 方法： 对2017年1月至2020年6月河南省人民医院病理科确诊的13例PWS和3例SWS的基因突变情况、形态学进行分析，并随访患者。 结果： 本组女性7例，男性9例，临床表现为出生即存在的皮肤红斑，镜下见不规则扩张畸形血管，累及真皮及皮下组织。3例SWS均为男性，年龄范围1~16岁，面部均见三叉神经分布区红斑，临床表现为继发性癫痫。切除脑组织表面可见迂曲怒张的小血管及毛细血管网；镜下脑组织表面软脑膜增厚，可见大量薄壁毛细血管，呈海绵状、蜂窝状或串珠状排列，无血管内皮细胞增生。14例进行高通量测序检测，结果10例PWS（76.9%）和1例SWS均存在GNAQ基因错义突变（R183Q）。 结论： PWS如出现累及三叉神经分布区的面部红斑应高度警惕SWS可能，后者最常累及软脑膜，呈较广泛毛细血管畸形；同时PWS及SWS中存在GNAQ基因突变，可作为与其他脉管畸形鉴别诊断的重要参考指标之一。.

Objective: To investigate the clinicopathological features, and differential diagnosis of verrucous hemangioma (VH). Methods: Twenty-eight VH cases diagnosed from 2005 to 2020 in Henan Provincial People's Hospital, Zhengzhou, China were analyzed retrospectively. Immunohistochemical studies used detect diagnostic markers. The mutation status PIK3CA (exons 9 20) was detected using fluorescence PCR. Results: There 13 males 15 females 28 cases, with male female ratio 1.0∶1.2. 25 patients under...