A5002460037- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- Phagocytosis and Immune Regulation
- Platelet Disorders and Treatments
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Renal Diseases and Glomerulopathies
Monash Medical Centre
2018-2024
Monash University
2018-2024
University of California, San Diego
2022-2024
Although effector CD4+ T cells readily respond to antigen outside the vasculature, how they intravascular antigens is unknown. Here we show process of recognition using intravital multiphoton microscopy glomeruli. undergo migration within uninflamed Similarly, while MHCII not expressed by intrinsic glomerular cells, MHCII-expressing immune patrol capillaries, interacting with cells. Following deposition in glomeruli, T-cell responses, including NFAT1 nuclear translocation and decreased...
Sterile inflammation is a central element in liver diseases. The immune response following injurious stimuli involves hepatic infiltration of neutrophils and monocytes. Neutrophils are major effectors inflammation, rapidly recruited to sites can augment the recruitment other leukocytes. NLRP3 inflammasome has been increasingly implicated severe fibrosis, cell death. In this study, role activation during fibrosis was investigated. Mouse models with neutrophil‐specific expression mutant were...
Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but can also promote thrombosis, autoimmunity, sterile inflammation. The presence of citrullinated histones, generated by the peptidylarginine deiminase 4 (PAD4), is synonymous with NETosis considered independent apoptosis. Mitochondrial- death receptor–mediated apoptosis gasdermin E (GSDME)–dependent calcium mobilization membrane permeabilization leading to histone H3 citrullination (H3Cit), nuclear DNA...
Abstract Objective The endothelial surface layer (ESL), a of macromolecules on the cells, can both impede and facilitate leukocyte recruitment. However, its role in monocyte neutrophil recruitment glomerular capillaries is unknown. Methods We used multiphoton intravital microscopy to examine behavior glomerulus following ESL disruption with hyaluronidase. Results Constitutive retention migration monocytes neutrophils within microvasculature was unaltered by Consistent this, inhibition...