A5103210293- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Radioactive contamination and transfer
- Ear and Head Tumors
- Nonmelanoma Skin Cancer Studies
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Nuclear and radioactivity studies
- Peptidase Inhibition and Analysis
- Growth Hormone and Insulin-like Growth Factors
- Reproductive Physiology in Livestock
- Single-cell and spatial transcriptomics
- Meningioma and schwannoma management
- Oral Health Pathology and Treatment
- Bone Tumor Diagnosis and Treatments
- Immunotherapy and Immune Responses
- Metabolism, Diabetes, and Cancer
- Radiation Dose and Imaging
- Contemporary Literature and Criticism
- Lipid metabolism and disorders
- NF-κB Signaling Pathways
- Milk Quality and Mastitis in Dairy Cows
- Graphite, nuclear technology, radiation studies
- Image Processing and 3D Reconstruction
Princess Alexandra Hospital
2013-2025
The University of Queensland
2024-2025
Royal Brisbane and Women's Hospital
2018
QIMR Berghofer Medical Research Institute
2018
NHS Tayside
2008
University of Waikato
2005-2008
PURPOSE This study evaluated DB-020, a formulation of thiosulfate for intratympanic (IT) injection, in patients receiving high-dose cisplatin chemotherapy. METHODS randomized phase Ib clinical trial enrolled older than 18 years from five centers Australia and the United States scheduled at least three cycles total cumulative exposure ≥280 mg/m 2 . Patients received IT DB-020 (at dose level either 12% or 25%) one ear placebo other, once every 3 4 weeks, within hours before cisplatin. The...
Women who were sent home from hospital in the latent phase of labour asked to keep a diary reflect on their experiences. Twenty-one women consented complete but only six returned it. These approached participate one-to-one interview at further explore effects being discharged home. Five agreed be interviewed. Interviews tape-recorded and transcribed verbatim. The data analyzed using content analysis. themes identified: influence others, reassurance, coping/pain, sleep deprivation...
Abstract Background The current study presents the effort of a global collaborative group to review management and outcomes malignant tumors skull base worldwide. Patients methods A total 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, multivariable factors associated with outcomes. Results median age was 56 years (IQR 44–67). open surgical approach used in 55% ( n = 1680) cases, endoscopic resection performed 36% 1087), combined...
Abstract Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis poor due to high rates of recurrence metastasis. With approximately one million new cases projected in 2024, worldwide mortality HNSCC estimated reach 50% detected same year. Patients with early-stage tumours showed a 50–60% five-year survival rate US. Immune checkpoint inhibitors (ICIs) have shown promising results prolonging subset patients recurrent or...
Abstract With nearly a million new cases expected, the global death rate from mucosal head and neck cancer is projected to reach around 50% in 2024. In U.S., patients with localized tumors have five-year survival of 50-60%. While immune checkpoint inhibitors (ICIs) shown promise extending survival, significant challenges remain, particularly limited effectiveness PD-1/PD-L1 blockade therapies. Since many studies that PD-L1 protein expression alone may not be reliable predictor response ICI...
Abstract Head and neck squamous cell carcinoma (HNSCC) is the cancer of different parts head region originating from epithelial cells mucosal layer. Globally, it 7th most common with over 89 thousand new cases each year. Its prognosis has not changed significantly in recent years despite improvements treatments options like immunotherapy, radiotherapy (RT), chemotherapy (CT) surgery. Using latest spatial omics technologies approaches, this work aims to develop a better insight tumour...
Summary The five-year survival rate for patients with head and neck squamous cell carcinoma (HNSCC) has remained at ~50% the past 30 years despite advances in treatment. Tigilanol tiglate (TT, also known as EBC-46) is a novel diterpene ester that induces death HNSCC vitro mouse models, recently completed Phase I human clinical trials. aim of this study was to optimise efficacy TT treatment by altering different administration parameters. tongue SCC line (SCC-15) identified lowest...
The incidence of nonmelanoma cutaneous head and neck malignancies is increasing worldwide. In a small percentage cases, associated perineural spread (PNS) cranial nerves occurs, resulting in poor prognosis, with recorded 5-year survival rate 50% to 64.3%. Patients clinical PNS from are treated surgical resection postoperative radiotherapy. Recent literature provides few reports that extends across the facial midline affect contralateral nerves. This report describes patients ipsilateral...
Advanced skull base malignancies are a heterogenous subset of head and neck cancers, management is often complex. In recent times, there has been paradigm shift in surgical technique the advent novel systemic options. Our goal was to analyse long-term outcomes single quaternary service.
Background Perineural spread (PNS) is a marker of aggressiveness and has been shown to occur in cranial nerves due advanced mucosal cutaneous head neck cancer. Receptors CXC chemokine receptor 4 (CXCR4) programmed cell death-1 (PD-1) have be overexpressed variety cancers with PNS, the inhibition these pathways offering potential future treatment. Methods Retrospective immunohistochemical staining for CXCR4 PD-1 receptors was performed on 28 specimens that demonstrated PNS from January 2017...
Most fire codes use only one or two radiation flux values when considering the external walls of buildings. If it is satisfactory to assume compartment temperatures are proportional time, then should be equally levels time. On this premise and using standard time-temperature curve, a wider than usual range design can derived which in step with FRR ratings. The method allows building designers more flexibility choice ordinary windows, both "mirror-image" "non mirror-image" situations.
6100 Background: Hearing loss (HL) as a result of cisplatin (CP) chemotherapy is common. DB-020 formulation sodium thiosulfate for intratympanic (IT) injection being developed to reduce CP ototoxicity. This phase 1 study was designed evaluate safety and tolerability repeated IT injections compare CP-induced hearing changes with vs placebo. Methods: Patients scheduled at least three cycles cumulative exposure ≥280 mg/m 2 were randomized blinded, bilateral, (12% or 25%) in one ear placebo the...
<title>Abstract</title> Mucosal head and neck squamous cell carcinoma (HNSCC) is a debilitating disease that accounts for an estimated 890,000 new cases per year, making it the seventh most common cancer globally. HNSCC heterogenous group of cancers affect various regions which stem from epithelial cells in mucosal lining. Despite advancements chemotherapy, radiotherapy, surgery immunotherapy, prognosis has remained relatively unchanged more than decade. There need to better understand...
<title>Abstract</title> Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis poor due to high rates of recurrence metastasis [1]. With approximately one million new cases projected in 2024, worldwide mortality HNSCC estimated reach 50% detected same year [2]. Patients with early-stage tumours showed a 50–60% five-year survival rate US. Immune checkpoint inhibitors (ICIs) have shown promising results prolonging subset...
<title>Abstract</title> Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis poor due to high rates of recurrence metastasis [1]. With approximately one million new cases projected in 2024, worldwide mortality HNSCC estimated reach 50% detected same year [2]. Patients with early-stage tumours showed a 50–60% five-year survival rate US. Immune checkpoint inhibitors (ICIs) have shown promising results prolonging subset...