A5061237087- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- Peripheral Artery Disease Management
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Optical Imaging and Spectroscopy Techniques
- Ultrasound and Hyperthermia Applications
- Intracranial Aneurysms: Treatment and Complications
- Thermography and Photoacoustic Techniques
- Medical Image Segmentation Techniques
- Advanced X-ray and CT Imaging
- Aortic aneurysm repair treatments
- Image and Signal Denoising Methods
- Ethics in Clinical Research
- Computer Graphics and Visualization Techniques
- Data Quality and Management
- Ultrasound Imaging and Elastography
- Research Data Management Practices
- Cardiovascular Function and Risk Factors
- Leprosy Research and Treatment
- Mechanical Failure Analysis and Simulation
- Amyloidosis: Diagnosis, Treatment, Outcomes
University of Toronto
2011-2024
Sunnybrook Health Science Centre
2014-2024
Health Sciences Centre
2011-2024
Colibri Technologies (Canada)
2012-2021
Sunnybrook Research Institute
2017-2020
Sunnybrook Hospital
2017-2020
Stanford University
2002-2011
North Shore Hospital
2011
Beth Israel Deaconess Medical Center
2011
Harvard University
2011
Objective To demonstrate the feasibility of imaging human coronary atherosclerosis using a novel hybrid intravascular ultrasound (IVUS) and optical coherence tomography (OCT) catheter. Background IVUS OCT have synergistic advantages recent studies involving both modalities suggest use catheter may offer improved guidance interventions plaque characterization. Methods A 1.3 m custom IVUS‐OCT probe was built within 4F 42 MHz transducer an fiber. Coplanar images were simultaneously acquired ex...
Feasibility of detecting intravascular flow using a catheter based endovascular optical coherence tomography (OCT) system is demonstrated in porcine carotid model vivo.The effects A-line density, radial distance, signal-to-noise ratio, non-uniform rotational distortion (NURD), phase stability the swept wavelength laser and interferometer on Doppler shift detection limit were investigated stationary phantoms.Techniques for NURD induced artifact removal developed by tracking sheath.Detection...
A novel flexible scanning optical probe is constructed with a finely etched fiber strung through platinum coil in the lumen of dissipative polymer. The packaged 2.2mm diameter rigid length 6mm when using ball lens or 12mm proximal to gradient-index (GRIN) lens. Driven by constant high voltage (1-3kV) at low current (<5μA), oscillates provide wide forward-viewing angle (13° and 33° GRIN designs, respectively) high-frame-rate (10-140fps) operation. Motion tip observed high-speed camera...
Introduction: Increasingly, the label “data trust” is being applied to repeatable mechanisms or approaches sharing data in a timely, fair, safe and equitable way. However, there gap terms of practical guidance about how establish operate trust.
 
 Aim Approach: In December 2019, Canadian Institute for Health Information Vector Artificial Intelligence convened working meeting 19 people representing 15 organizations/initiatives involved sharing, most which focus on public sector...
Coronary wall cardiovascular magnetic resonance (CMR) is a promising noninvasive approach to assess subclinical atherosclerosis, but data are limited in subjects over 60 years old, who at increased risk. The purpose of the study was evaluate coronary CMR an asymptomatic older cohort. Cross-sectional images proximal right artery (RCA) were acquired using spiral black-blood (0.7 mm resolution) 223 older, community-based patients without history disease (age 60-72 38% female). measurements...
Abstract Objectives: To examine the influence of vessel wall calcium on neointimal hyperplasia (NIH) following bare metal stent (BMS) and drug‐eluting (DES) implantation. Background: While procedural complications with coronary stenting in calcified lesions are well reported, little is known about subsequent NIH plaque either BMS or DES Methods: In Study to COmpare REstenosis Rate between QueST QuaDDS‐QP2 (SCORE) trial, 6 months follow‐up volumetric intravascular ultrasound data were...
The NEVO sirolimus-eluting stent (NEVO SES) is a novel cobalt-chromium combining sirolimus release from reservoirs with bioabsorbable polymer to reduce spatial and temporal exposure. aim of this study was assess the arterial response SES in randomized, blinded comparison versus surface-coated TAXUS Liberte paclitaxel-eluting (TAXUS Liberté PES) human native coronary lesions using intravascular ultrasound (IVUS).The ResElution-I IVUS substudy enrolled 100 patients (1:1 randomization). In...
A prototype intraoperative hand-held optical coherence tomography (OCT) imaging probe was developed to provide micron resolution cross-sectional images of subsurface tissue during open surgery. This new ergonomic designed based on electrostatically driven fibers, and packaged into a catheter in the form factor clinically accepted Bayonet shaped neurosurgical probes. Optical properties were measured have ~20 μm spot size, 5 mm working distance 4 field view. Feasibility this for structural...
Abstract Aims We evaluated the first in‐human performance of a novel hybrid imaging catheter that permits simultaneous and co‐registered acquisition intravascular ultrasound (IVUS) optical coherence tomography (OCT) images. Methods Results A total 17 patients undergoing planned percutaneous coronary intervention (PCI) were imaged between August 2018 2019. Eleven with both pre‐ post‐PCI IVUS OCT images included in offline image analysis. analyzed separately then together for pre‐stent...
Abstract Background and Objectives Percutaneous coronary interventions (PCI) of chronic total occlusions (CTOs) arteries are more challenging lesions to treat with angioplasty stenting than stenotic vessels due primarily the difficulty in guiding wire across lesion. Angiography alone is unable differentiate between occluded lumen vessel wall characterize content occlusion. New technologies aid interventional guidance therefore highly desirable. We sought evaluate tissue characterization...
Abstract Temperature heterogeneity along the inner surface of an artery may be a surrogate marker impending plaque rupture and has been associated with increased likelihood future coronary events. Initial studies using catheter‐based thermographic devices have demonstrated that changes in temperature are subtle, while effects flow on measured not yet examined. A novel guidewire‐based system (ThermoCoil, Imetrx) designed to measure arteries was used study heat source intensity temperature. An...
Lipid composition of atherosclerotic plaques is considered to be highly related plaque vulnerability. Therefore, a specific diagnostic or imaging modality that can sensitively evaluate plaques' necrotic core desirable in atherosclerosis imaging. In this regard, intravascular photoacoustic (IVPA) an emerging detection technique provides lipid-specific chemical information from arterial wall with great optical contrast and long acoustic penetration depth. While, the near-infrared window,...