A5028397295- Cystic Fibrosis Research Advances
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Carbohydrate Chemistry and Synthesis
- Respiratory and Cough-Related Research
- Pneumonia and Respiratory Infections
- Pulmonary Hypertension Research and Treatments
- Glutathione Transferases and Polymorphisms
- RNA modifications and cancer
- Inflammasome and immune disorders
- Molecular Biology Techniques and Applications
- Cardiovascular and Diving-Related Complications
- Geriatric Care and Nursing Homes
- Adrenal Hormones and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Retirement, Disability, and Employment
- Parkinson's Disease Mechanisms and Treatments
- Environmental DNA in Biodiversity Studies
- Head and Neck Cancer Studies
UC San Diego Health System
2025
University of California, San Diego
2025
University of Wisconsin–Madison
2017-2023
Foghorn Therapeutics (United States)
2023
Tufts University
2023
University of Wisconsin Carbone Cancer Center
2020
University of Technology Sydney
2015
The University of Western Australia
2005-2011
The Kids Research Institute Australia
2001-2011
Institute of Child Health
2006
Background. We hypothesized that the inflammatory response in lungs of children with cystic fibrosis (CF) would vary type infecting organism, being greatest Pseudomonas aeruginosa and Staphylococcus aureus. Methods. A microbiological surveillance program based on annual bronchoalveolar lavage (BAL) collected fluid for culture assessment inflammation was conducted. Primary analyses compared samples grew a single organism uninfected cross-sectional longitudinal analyses. Results. Results were...
When do infants and young children with cystic fibrosis acquire infection Pseudomonas aeruginosa ? Can this be eradicated when first detected? Children <6 yrs of age participated in an annual bronchoalveolar lavage (BAL)-based microbiological surveillance programme Perth, Australia. P. was detected, eradication using combination treatment i.v. , oral nebulised antibiotics undertaken. Repeat BAL performed 3 months following treatment, to assess success. detected 33 (28.4%) children; median...
<h3>Introduction</h3> Improved nutrition is the major proven benefit of newborn screening programmes for cystic fibrosis (CF) and associated with better clinical outcomes. It was hypothesised that early pulmonary inflammation infection in infants CF worse nutrition. <h3>Methods</h3> Weight, height bronchoalveolar lavage (BAL) were assessed shortly after diagnosis again at 1, 2 3 years age. Body mass index (BMI) expressed as z-scores. Inflammatory cells cytokines (interleukin 1β (IL-1β),...
<b>Background:</b> Lung disease in cystic fibrosis (CF) is established early childhood with recurrent bacterial infections and inflammation. Using spirometry, the effect of this lung damage cannot be measured until a child 6 years age when some irreversible may already have occurred. Techniques for measurement function infants young children include raised volume rapid thoracic compression (RVRTC) low frequency forced oscillation (LFFOT). The aim study was to investigate role inflammation...
Airway inflammation is an important component of cystic fibrosis (CF) lung disease. We sought to determine whether alveolar macrophages were involved in early CF Children with (median age 3.1 yrs) participated a surveillance programme that included annual bronchoalveolar lavage (BAL). Control samples obtained from non-CF children yrs; n = 24) investigated for persistent respiratory symptoms. Pulmonary infection was detected 31% (16 out 51) and 38% (nine the groups, respectively. Alveolar BAL...
Abstract Housekeeping genes (HKGs) are essential for basic maintenance of a variety cellular processes. They ideally maintain uniform expression independent experimental conditions. However, the effects ionizing radiation (IR) on HKG is unclear. Statistical algorithms, geNorm and Normfinder were used estimating stability HKGs as raw quantification cycle (Cq) values not reliable factor normalization. Head neck, non-small lung pancreas cells exposed to 2, 4 6 Gy IR doses fourteen was measured...
This is the first study to measure inducible nitric oxide synthase (iNOS) gene and protein expression quantitatively in primary epithelial cells from very young children with cystic fibrosis (CF). Low levels of exhaled (NO) CF suggest dysregulation NO production airway. Due importance cell homeostasis innate immunity, any defect pathway associated would be a potential target for treatment.Cells were obtained by tracheobronchial brushing 40 mean (SD) age 2.1 (1.5) years 12 healthy non-atopic...
<h3>Background</h3> Early detection of <i>Pseudomonas aeruginosa</i> is essential for successful eradication. The accuracy serum antibodies against specific and multiple <i>P antigens at predicting lower airway infection in young children with cystic fibrosis (CF) was investigated. <h3>Methods</h3> A commercial antigen (MAg) ELISA an in-house exotoxin (ExoA) were compared two populations: a discovery population 76 (0.1–7.1 years) undergoing annual bronchoalveolar lavage (BAL)-based...
Introduction: Patent Foramen Ovale (PFO) contributes to a quarter of Embolic strokes Undetermined Source (ESUS). Although benefit PFO closure in selected patients has been demonstrated, our workflow resulted low rate evaluation for closure. The aim the PFO-ACCESS program (which included implementation Viz.ai PFO-specific communications module) was determine any change management due improved communication between stroke and interventional cardiology (IC) teams. Methods: In this Quality...
BACKGROUND Patent foramen ovale (PFO) contributes to a quarter of embolic strokes undetermined source. Although the benefit PFO closure in selected patients has been demonstrated, our system workflow still resulted low rate evaluation for closure. The aim PFO‐ACCESS (Augmenting Communications Medical Care or Closure Evaluation Stroke Patients With Cardiac Shunts) program (which included implementation Viz.ai PFO‐specific communications module) was determine if there any change management due...
FGFRs are commonly altered in non-small cell lung cancer (NSCLC). activate multiple pathways including RAS/RAF/MAPK, PI3K/AKT, and STAT, which may play a role the cellular response to radiation. We investigated effects of combining selective FGFR 1-3 tyrosine kinase inhibitor AZD4547 with radiation line xenograft models NSCLC. NSCLC lines were assessed proliferation, clonogenic survival, apoptosis, autophagy, cycle, DNA damage signaling repair assays. In vivo xenografts IHC used confirm...
<h3>BACKGROUND</h3> The aim of this study was to compare neutrophil migration in cystic fibrosis (CF) and non-CF populations investigate the effect erythromycin on directed neutrophils (PMNs) CF. <h3>METHODS</h3> PMNs were isolated their migratory capacity response interleukin-8 (IL-8) or f-Met-Leu-Phe (fMLP) presence absence (1–100 μg/ml) assessed. <h3>RESULTS</h3> CF derived showed significantly increased IL-8 but not fMLP compared with PMNs. Erythromycin had no significant responses vitro...
Fractional exhaled nitric oxide (F eNO ) has been reported to be reduced in cystic fibrosis (CF) patients. However, data from young children are conflicting and it is not clear whether this a primary feature of the disease or secondary response. The present study compared F between CF healthy infants using validated single-breath technique. A total 23 (11 females; mean age 40.1 weeks) 18 with (nine 64.9 underwent tests lung function . Bronchoalveolar lavage (BAL) was collected all 2–5 days...
3,4,6-Tri-O-acetyl-2-O-benzyl-α-D-glucopyranosyl bromide has been prepared. Treatment with silver acetate gave 1,3,4,6-tetra-O-acetyl-2-O-benzyl-β-D-glucopyranose; methanolysis methyl 3,4,6-tri-O-acetyl-2-O-benzyl-β-D-glucopyranoside.
Objective: The aim of this study was to determine whether nasal inflammation reflects pulmonary in young children with cystic fibrosis (CF), as assessed by inflammatory markers wash (NW) and bronchoalveolar lavage (BAL), respectively. Methods: CF patients younger than 6 years age who were undergo bronchoscopy for routine BAL from May 2000 October 2001 recruited study. NW collected immediately after the patient sedated bronchoscopy. Total cell counts (TCC), differential interleukin (IL)‐8...
Abstract Acute myeloid leukemia (AML) is a complex disease with multiple sub-types, each characterized by unique clinical and molecular features, driving the need to develop targeted therapies which exploit specific vulnerabilities. Bromodomain-containing protein 9 (BRD9) component of ncBAF chromatin remodeling complex, has been recently indicated as strong dependency in AML (Weisberg et al 2022). It shown that inhibitors BRD9 induce growth inhibition expression apoptotic makers cell lines...
Summary Eight subjects induced bronchospasm by free‐range running. Four of these demonstrated a hue response at 5‐6 hr after exercise. When compared lo the other group four subjects, who also developed an early but no late response, difference in FEV 1 was highly statistically significant. Although phenomenon is not universally manifest it should longer be held that there exercise‐induced asthma.
Early acquisition of Pseudomonas aeruginosa is associated with a poorer prognosis in patients cystic fibrosis. We investigated whether polymorphisms CD14, the lipopolysaccharide receptor, increase risk early infection. Forty-five children fibrosis were annual bronchoalveolar lavage (BAL) and plasma sCD14 levels. Plasma levels significantly lower from whom P.aeruginosa was subsequently isolated (492.75 μg/ml vs. 1339.43 μg/ml, p = 0.018). Those CD14 -159CC genotype had increased infection...
Abstract The Cancer Genome Atlas (TCGA) has identified alterations such as amplification, deletion, or mutation of androgen receptor (AR) in about 5% human lung squamous cell carcinoma and adenocarcinoma. expression AR appears to play a crucial role development type II pneumocytes (PTII) maturation, but unlike prostate cancer, the is not well known non-small cancer (NSCLC). In our study, we demonstrated NSCLC lines translocated into nucleus over time when stimulated with synthetic R1881,...
Abstract Objective: Fibroblast growth factor receptors are frequently amplified or overexpressed in head and neck squamous cell carcinomas (HNSCC). We assessed the potential of a selective FGFR-kinase inhibitor, AZD4547, to act as radiosensitizer cancer lines xenografts. Methods: A panel (n=10) normal oral mucosa (HTE) were screened for FGFR1, 2, 3 gene copy number, RNA expression, protein. Sensitivity FGFR inhibitor alone combination with radiation, was using proliferation clonogenic...