A5048336441- Effects and risks of endocrine disrupting chemicals
- Microplastics and Plastic Pollution
- Recycling and Waste Management Techniques
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Infant Development and Preterm Care
- Gut microbiota and health
- Maternal Mental Health During Pregnancy and Postpartum
- Child Nutrition and Feeding Issues
- Heavy metals in environment
- Toxic Organic Pollutants Impact
- Child and Adolescent Health
- Infant Health and Development
- Genetic Associations and Epidemiology
- Child Development and Digital Technology
- Pluripotent Stem Cells Research
- Pediatric health and respiratory diseases
- Tryptophan and brain disorders
- Carcinogens and Genotoxicity Assessment
- Fatty Acid Research and Health
- Heavy Metal Exposure and Toxicity
- Municipal Solid Waste Management
- Stress Responses and Cortisol
Murdoch Children's Research Institute
2015-2025
Royal Children's Hospital
2014-2025
Minderoo Foundation
2021-2025
The University of Melbourne
2013-2025
Walk Free Foundation
2021-2025
PolicyWise for Children & Families
2025
Barwon Health
2013-2021
University of Edinburgh
2004-2005
The arterial pulse-wave transit time can be measured between the ECG R-wave and finger pulse (rPTT), has been shown previously to have a linear correlation with blood pressure (BP). We hypothesized that relationship rPTT, preejection period (PEP; R-wave/mechanical cardiac delay), BP would vary different vasoactive drugs. Twelve healthy men (mean age 22 yr) were studied. Beat-to-beat measurements made of rPTT (using photoplethysmograph probe), intra-arterial radial pressure, PEP...
Abstract A study has been made of the amounts cadmium recovered by a variety reagents and extraction procedures from soils to which Cd added. Correlation these results with content radish plants ( Raphanus sativus L. cultivar French Breakfast Crimson (Suttons)) grown in shown that most sensitive several possible indices uptake is amount extracted 1‐hour shaking 1/V ammonium nitrate solution at soil/solution ratio 1:10 (wt/vol). The greater efficiency this extractant compared other proposed...
The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including utero), the aetiology many NCDs, though cellular/molecular mechanism(s) underlying this elevated risk across course remain unclear. Epigenetic variation has emerged as a candidate mediator such effects. Barwon Infant Study (BIS) population-derived birth cohort study (n = 1074 infants) antenatal...
Abstract In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of disease low gastrointestinal carriage Prevotella , a commensal bacterial genus that produces short chain fatty acids endotoxins, each which may promote tolerance. this study, we use prebirth cohort ( n = 1064 mothers) to conduct nested case-cohort study comparing 58 mothers babies with clinically proven food IgE mediated allergy 258...
BackgroundDespite intense interest in the relationship between gut microbiota and brain development, longitudinal data from human studies are lacking. This study aimed to investigate composition of during infancy subsequent behavioural outcomes.MethodsA subcohort 201 children with outcome measures was identified within a longitudinal, Australian birth-cohort study. The faecal were analysed at 1, 6, 12 months age. Behavioural outcomes measured 2 years age.FindingsIn an unselected birth...
BackgroundMurine studies demonstrate that maternal prenatal gut microbiota influences brain development and behaviour of offspring. No human study has related to behavioural outcomes during early life. This aimed evaluate relationships between the faecal microbiota, diet childhood behaviour.MethodsA sub-cohort 213 mothers 215 children were selected from a longitudinal pre-birth cohort. Maternal exposure measures collected third trimester included (generated using 16S rRNA amplicon...
The global production and use of plastic materials has increased dramatically since the 1960s there is increasing evidence human health impacts related to exposure plastic-associated chemicals. There is, however, no comprehensive, regulatory, post-market monitoring for effects chemicals or particles it unclear how many these have been investigated in humans, therefore what knowledge gaps are.To create a systematic map peer-reviewed studies investigating potential particles/chemicals on...
Male sex, early life chemical exposure and the brain aromatase enzyme have been implicated in autism spectrum disorder (ASD). In Barwon Infant Study birth cohort (n = 1074), higher prenatal maternal bisphenol A (BPA) levels are associated with ASD symptoms at age 2 diagnosis 9 only males low genetic pathway activity scores. Higher BPA predictive of cord blood methylation across CYP19A1 promoter I.f region (P 0.009) gene mediates 0.01) link between brain-derived neurotrophic factor...
Mounting evidence finds that early life environmental factors increased the probability of autism spectrum disorder. We estimated prospective associations between and disorder symptoms in children at age 2 years a population-derived birth cohort, Barwon Infant Study. Autism strongly predicted diagnosis by 4 (area under curve = 0.93; 95% CI (0.82, 1.00)). After adjusting for child’s sex time behavioural assessment, markers socioeconomic disadvantage, such as lower household income lone...
Abstract This study attempted to assess the validity of tree‐ring analysis in tracing history pollution an area exposed high atmospheric concentrations heavy metals from a smelting complex. Tree cores, bark samples, and soil samples were collected two sites, one close other distant source emission. The analyzed for cadmium, zinc, copper, lead. It could be shown that reduction growth at site exposure was positively correlated with tree cores copper lead but not zinc cadmium. data show clear...
Micro and nanosized plastics (MNPs), a range of associated additive chemicals, have become pervasive contaminants that humans the environment are exposed to everyday. However, one principal challenges in their analysis is adequate strategies minimise background contamination. Here blueprint for specialised additive-minimised clean room laboratory built this purpose presented. Common construction materials (n = 23) were tested, including acoustic baffles, ceiling materials, floor glazing...
Aim Concurrence between parents' information needs and clinicians' practice when diagnosing autism is unknown but may influence families' uptake of management adjustment. We aimed to compare experience preferences with paediatrician report (i) diagnosis delivery (ii) given at identify types usefulness resources accessed by families post‐diagnosis. Methods The design used for the study are parent surveys. Participants parents children aged 1.5–18 years, diagnosed 01 January 2010 30 September...
Human exposure to phthalate chemicals, used in consumer product plastics, occurs throughout the day. Phthalate levels pregnant women are associated with offspring health effects including obesity and neurodevelopmental problems. Knowledge of predictors is necessary order effectively reduce exposure. The present study aims identify Australian from Barwon Infant birth cohort. Maternal urine samples 841 were analyzed for metabolites. diet food preparation practices, use volatile household...
More than 16,000 chemicals are incorporated into plastics to impart properties such as color, flexibility, and durability. These may leach from plastics, resulting in widespread human exposure during everyday use. Two plastic-associated chemicals—bisphenol A (BPA) di(2-ethylhexyl) phthalate (DEHP)—and a class of chemicals—brominated flame retardants [polybrominated diphenyl ethers (PBDEs)]—are credibly linked adverse health cognitive impacts. BPA exposures associated with ischemic heart...
More than 8 billion tonnes of plastic were produced between 1950 and 2015, that is 1 tonne for every man, woman child on our planet. Global production has been growing exponentially with an annual growth rate 8.4% since 1950, equating to approximately 380 million per annum. A further 50 kg now being each person year continuing accelerate. Here, we discuss the human planetary health hazards all plastic. We consider step in journey these complex pervasive industrial materials: from their...
Prenatal phthalate exposure has previously been linked to the development of autism spectrum disorder (ASD). However, underlying biological mechanisms remain unclear. We investigated whether maternal and child central carbon metabolism is involved as part Barwon Infant Study (BIS), a population-based birth cohort 1,074 Australian children. estimated daily intakes using third-trimester urinary metabolite concentrations other relevant indices. The metabolome serum in third trimester, cord at...