A5101544423- Effects and risks of endocrine disrupting chemicals
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Sclerosis and Related Diseases
- Vitamin D Research Studies
- Anesthesia and Neurotoxicity Research
- Epigenetics and DNA Methylation
- Gastrointestinal motility and disorders
- Cancer Immunotherapy and Biomarkers
- Birth, Development, and Health
- Autoimmune and Inflammatory Disorders
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 Clinical Research Studies
- Microplastics and Plastic Pollution
- Osteoarthritis Treatment and Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Vasculitis and related conditions
- Pharmaceutical Practices and Patient Outcomes
- Anorectal Disease Treatments and Outcomes
- Urticaria and Related Conditions
- Hepatocellular Carcinoma Treatment and Prognosis
- Maternal Mental Health During Pregnancy and Postpartum
- Microscopic Colitis
- Animal Genetics and Reproduction
- Diabetic Foot Ulcer Assessment and Management
Florey Institute of Neuroscience and Mental Health
2022-2024
The University of Melbourne
2023-2024
University Hospitals of Cleveland
2022
Male sex, early life chemical exposure and the brain aromatase enzyme have been implicated in autism spectrum disorder (ASD). In Barwon Infant Study birth cohort (n = 1074), higher prenatal maternal bisphenol A (BPA) levels are associated with ASD symptoms at age 2 diagnosis 9 only males low genetic pathway activity scores. Higher BPA predictive of cord blood methylation across CYP19A1 promoter I.f region (P 0.009) gene mediates 0.01) link between brain-derived neurotrophic factor...
Childhood mental disorders, including emotional and behavioural problems (EBP) are increasingly prevalent. Higher maternal oxidative stress (OS) during pregnancy (matOSpreg) is linked to offspring disorders. Environmental factors contribute matOSpreg. However, the role of matOSpreg in childhood EBP unclear. We investigated associations between (i) EBP; (ii) social prenatal environmental matOSpreg; (iii) evaluated whether mediated these associations. Maternal urinary OS biomarkers,...
Increasing evidence implicates prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP), a common endocrine-disrupting plastic chemical, in autism spectrum disorder (ASD) and attention-deficit/hyperactivity (ADHD). However, the underlying mechanisms are poorly understood. Here we examined whether cord blood DNA methylation, key epigenetic marker, mediates association between DEHP ASD/ADHD symptoms 847 children enrolled Barwon Infant Study. ASD ADHD complex phenotypes characterised by...
The developing brain is highly sensitive to environmental disturbances, and adverse exposures can act through oxidative stress. Given that stress susceptibility determined partly by genetics, multiple studies have employed genetic scores explore the role of in human disease. However, traditional approaches score construction face a range challenges, including lack interpretability, bias towards disease outcome, often overfitting study they were derived on. Here, we develop an alternative...
Phthalates, chemical additives used to enhance plastic products' flexibility, are easily released into the environment, and can harm brain development through various mechanisms including inflammation. Genetic variation influencing an individual's susceptibility inflammation may play a role in effects of phthalate exposure on neurodevelopment however there is no summary measure developed for genetic
Upper gastrointestinal bleeding (UGIB) is a common and potentially life-threatening condition. Metastatic disease an exceedingly rare cause of UGIB. We report the case 73-year-old man with high-grade B-cell lymphoma (HGBL) who presented for initiation chemotherapy was found to be acutely anemic due An esophagogastroduodenoscopy (EGD) revealed multiple large, discrete, ulcerated, non-circumferential, friable masses in stomach. Biopsies were consistent HGBL. The patient urgently initiated on...
Introduction: The differential for colitis is broad, including infectious, ischemic, diverticulitis, inflammatory bowel disease and vasculitis etiologies. In this report, we present the case of a patient who presented with acute anemia in setting along chronic sinusitis, palpable purpura, renal failure was eventually found to have granulomatosis polyangiitis (GPA). Case Description/Methods: A 51-year-old man 3-month history sinusitis refractory antibiotics 2-week diarrhea intermittent...