A5045683410- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer Research and Treatments
- Metabolism, Diabetes, and Cancer
- Voice and Speech Disorders
- Pressure Ulcer Prevention and Management
- Diagnosis and Treatment of Venous Diseases
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Venous Thromboembolism Diagnosis and Management
- Tracheal and airway disorders
- Bird parasitology and diseases
- Head and Neck Anomalies
- Influenza Virus Research Studies
- Atrial Fibrillation Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Oral health in cancer treatment
- Cardiac Arrhythmias and Treatments
- Management of metastatic bone disease
- Multiple Myeloma Research and Treatments
- Microbial Metabolism and Applications
- Phytochemical compounds biological activities
The Ohio State University
2020
University of Kansas Medical Center
2015-2018
Edinburgh Royal Infirmary
1995-1999
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts (CAF). We previously reported that CAF-secreted HGF facilitates progression; however, very little known about the role CAFs in metabolism. Here, we demonstrate increases extracellular lactate levels via upregulation glycolysis. induced basic FGF (bFGF) secretion from HNSCC. were...
Benign laryngeal lesions represent a diverse set of pathologies whose clinical presentation may range from no symptoms to dyspnea and/or dysphonia. Flexible fiberoptic laryngoscopy and videolaryngostroboscopy are important in distinguishingdifferent types lesions, management treatment dependent on the identification these as they have different etiologies. Some such vocal fold nodules polyps primarily phonotraumatic benefit fromspeech therapy hygiene initial approaches. Vocal cysts benign...
Abstract Objectives To determine whether patients undergoing in‐office laryngologic procedures on antithrombotic therapy are at increased risk for treatment‐related complications. Methods Patients were those who underwent least one procedure with any of three fellowship‐trained laryngologists. Procedures identified by current procedural terminology (CPT) code and included biopsies, excisions, laser ablations, injections (therapeutic augmentative). divided into two groups based the use time...
Abstract Head and neck squamous cell carcinoma (HNSCC) have a propensity for aggressive growth metastasis, with high morbidity low 5-year survival rates. Despite advances in treatment, the overall rate has only modestly improved over past several years. Herbal tea extract from root leaves of Arum palaestinum been used to prevent facilitate treatment cancer Palestine. Very few studies addressed mechanisms antitumor efficacy this neutraceutical. Here we tested synthetic formulations (GZ17-S,...
Abstract Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC), which affects 50,000 new patients annually in the United States, is associated with less than 50% 5-year survival. HNSCC tumors display increased glycolysis, even presence of oxygen. Consequently, there an increase lactic acid (LA) production. However, effect tumor microenvironment mechanisms whereby survive highly acidic conditions remain unknown. consist up to 80% tumor-associated fibroblasts (TAFs). We...
<p>CAF secreted HGF mediates HNSCC glycolysis.</p>
<p>HNSCC Cells have Higher Glycolytic Capacity than CAFs and Maximal Respiration HNSCC.</p>
<p>Combination of AZD-4547 and PF-02341066 indicates potentiated effect in admixed cultures but not HNSCC only inoculated tumors.</p>
<p>Endogenous expression of bFGF in HNSCC and FGFR CAFs.</p>
<div>Abstract<p>Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts (CAF). We previously reported that CAF-secreted HGF facilitates progression; however, very little known about the role CAFs in metabolism. Here, we demonstrate increases extracellular lactate levels via upregulation glycolysis. induced basic FGF (bFGF)...
<p>HNSCC Cells have Higher Glycolytic Capacity than CAFs and Maximal Respiration HNSCC.</p>
<p>Legends for all supplemental figures</p>
<p>Legends for all supplemental figures</p>
<div>Abstract<p>Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts (CAF). We previously reported that CAF-secreted HGF facilitates progression; however, very little known about the role CAFs in metabolism. Here, we demonstrate increases extracellular lactate levels via upregulation glycolysis. induced basic FGF (bFGF)...
<p>Endogenous expression of bFGF in HNSCC and FGFR CAFs.</p>
<p>CAF secreted HGF mediates HNSCC glycolysis.</p>
<p>Combination of AZD-4547 and PF-02341066 indicates potentiated effect in admixed cultures but not HNSCC only inoculated tumors.</p>