A5055075644- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Cancer Research and Treatments
- Histone Deacetylase Inhibitors Research
- Metabolism, Diabetes, and Cancer
- SARS-CoV-2 and COVID-19 Research
- Head and Neck Surgical Oncology
- Effects of Radiation Exposure
- COVID-19 and healthcare impacts
- Cancer-related Molecular Pathways
- AI in cancer detection
- Soft tissue tumor case studies
- Pancreatic and Hepatic Oncology Research
- Management of metastatic bone disease
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
Scripps Research Institute
2024
Scripps Health
2024
Scripps Clinic
2022-2024
University of Kansas Medical Center
2015-2022
Scripps Green Hospital
2022
University of Kansas
2018-2021
The University of Kansas Cancer Center
2017-2018
University Medical Center
2017-2018
University Hospital and Clinics
2017-2018
Despite therapeutic advancements, there has been little change in the survival of patients with head and neck squamous cell carcinoma (HNSCC). Recent results suggest that cancer-associated fibroblasts (CAF) drive progression this disease. Here, we report autophagy is upregulated HNSCC-associated CAFs, where it responsible for key pathogenic contributions Autophagy fundamentally involved degradation, but emerging evidence suggests also important cellular secretion. Thus, hypothesized...
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts (CAF). We previously reported that CAF-secreted HGF facilitates progression; however, very little known about the role CAFs in metabolism. Here, we demonstrate increases extracellular lactate levels via upregulation glycolysis. induced basic FGF (bFGF) secretion from HNSCC. were...
Predicting survival of oral squamous cell carcinoma through the use prediction modeling has been underused, and development models would augment clinicians' ability to provide absolute risk estimates for individual patients.To develop a model using machine learning 5-year overall among patients with compare this created from TNM (Tumor, Node, Metastasis) clinical pathologic stage.A retrospective cohort study was conducted 33 065 National Cancer Data Base between January 1, 2004, December 31,...
mTOR inhibition of aromatase inhibitor (AI)-resistant breast cancer is currently under evaluation in the clinic. Everolimus/RAD001 (Afinitor®) has had limited efficacy as a solo agent but projected to become part combination therapy for AI-resistant cancer. This study was conducted investigate anti-proliferative and resistance mechanisms everolimus cells. In this we utilized two cell lines, MCF-7:5C MCF-7:2A, which were clonally derived from estrogen receptor positive (ER+) MCF-7 cells...
Epithelial ovarian cancer (EOC) has poor prognosis and rapid recurrence because of widespread dissemination peritoneal metastases at diagnosis. Multiple pathways contribute to the aggressiveness cancer, including hypoxic signaling mechanisms. In this study, we have determined that hypoxia-inducible histone demethylase KDM4B is expressed in ∼60% EOC tumors assayed, primary matched metastatic tumors. Expression positively correlated with expression tumor hypoxia marker CA-IX, robustly induced...
To apply a novel methodology with machine learning (ML) to large national cancer registry help identify patients who are high risk for delayed adjuvant radiation.Observational cohort study.National Cancer Database (NCDB).A total of 76,573 were identified from the NCDB had invasive head and neck underwent surgery, followed by radiation. The model was constructed 80% patient data subsequently evaluated scored remaining 20%. Permutation feature importance analysis used understand weighted...
Hearing loss (HL) is the most common neurodegenerative disease worldwide. Despite its prevalence, clinical testing does not yield a cell or molecular based identification of underlying etiology hearing making development pharmacological treatments challenging. A key to improving diagnosis inner ear disorders reliable biomarkers for different diseases. Analysis microRNAs (miRNA) in tissue and body fluid samples has gained significant momentum as diagnostic tool wide variety In previous work,...
Background Despite immunization, patients on antineoplastic and immunomodulating agents have a heightened risk of COVID-19 infection. However, accurately attributing this to specific medications remains challenging. Methods An observational cohort study from December 11, 2020 September 22, 2022, within large healthcare system in San Diego, California, USA was designed identify associated with greatest postimmunization SARS-CoV-2 Adults prescribed WHO Anatomical Therapeutic Chemical (ATC)...
Abstract Head and neck squamous cell carcinoma (HNSCC) is associated with low survival, the current aggressive therapies result in high morbidity. Nutraceuticals are dietary compounds few side effects. However, limited antitumor efficacy has restricted their application for cancer therapy. Here, we examine combining nutraceuticals, establishing a combination therapy that more potent than any singular component, delineate mechanism of action. Three formulations were tested: GZ17-S (combined...
Abstract We previously reported that ionizing radiation (IR) mediates cell death through the induction of CUGBP elav‐like family member 2 (CELF2), a tumor suppressor. CELF2 is an RNA binding protein modulates mRNA stability and translation. Since IR induces autophagy, we hypothesized regulates autophagy‐mediated colorectal cancer (CRC) death. For clinical relevance, determined levels in The Cancer Genome Atlas (TCGA). Role response was carried out CRC lines by immunoblotting,...
Abstract Doublecortin like kinase 1 (DCLK1) plays a crucial role in several cancers including colon and pancreatic adenocarcinomas. However, its squamous cell carcinoma (SCC) remains unknown. To this end, we examined DCLK1 expression head neck SCC (HNSCC) anal (ASCC). We found that is elevated patient tissue, which correlated with cancer progression poorer overall survival. Furthermore, significantly human papilloma virus negative HNSCC, are typically aggressive poor responses to therapy....
Radiation-induced fibrosis (RIF) is a major side effect of radiotherapy in cancer patients with no effective therapeutic options. RIF involves excess deposition and aberrant remodeling the extracellular matrix (ECM) leading to stiffness tissues organ failure. Development preclinical models crucial elucidate molecular mechanisms regulating develop approaches. In addition radiation, main perpetrators fibrotic reactions are cytokines, including transforming growth factor-β (TGF-β). We...
Background Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor that presents in adolescent males. Although surgical excision the mainstay of treatment, recurrences complicate treatment. There need to develop less invasive approaches for management. JNA tumors are composed fibroblasts and vascular endothelial cells. We identified fibroblast growth factor receptor (FGFR) (VEGF) expression JNA‐derived fibroblasts. FGFR influences proliferation VEGF necessary angiogenesis. hypothesized...
Prescription drug stewardship is critical. Autopopulation(AP) of medication quantities may influence prescriber behaviour. We investigate the impact AP removal(APR) on opioid prescribing.Inpatient and emergency department(ED) discharges with pain medications 2 years before after APR were identified. Milligrams morphine equivalents(MMEs) prescribed recorded. Group comparisons performed using Mann-Whitney U tests. Spearman's rho was used to analyse correlations between level quantity opioids....
Healthcare workers (HCWs) were among the first group of people vaccinated with Pfizer-BioNTech Covid-19 vaccine (BNT162b2). Characterization kinetics antibody response to vaccination is important devise future strategies. To better characterize BNT162b2, we analyzed IgG and IgM 5 different SARS-CoV-2 epitopes over a period 6 months.An observational single-centered study was conducted evaluate temporal dynamics anti-SARS-CoV-2 antibodies following immunization two doses BNT162b2....
Juvenile nasopharyngeal angiofibroma (JNA) is a highly vascularized and locally aggressive tumor that typically presents in adolescent males. The molecular biology of this remains understudied. We sought to identify differentially expressed genes the JNA transcriptome through messenger RNA sequencing primary fibroblasts from 2 explants tonsil tissue tumor‐free subjects. In total, 1088 significant, were identified with 749 upregulated 339 downregulated. Pathway analysis number activated...
This study seeks to (1) demonstrate how machine learning (ML) can be used for prediction modeling by predicting the treatment patients with T1-2, N0-N1 oropharyngeal squamous cell carcinoma (OPSCC) receive and (2) assess impact patient, socioeconomic, regional, institutional factors have in of this population.A retrospective cohort adults diagnosed OPSCC from 2004 2013 was obtained using National Cancer Database. The data split into 80/20 distribution training testing, respectively. Various...
e17026 Background: Prostate cancer, the leading cause of cancer mortality in men, has seen notable advances with PSMA-targeted therapies like 177Lu-PSMA-617 (Pluvicto), particularly metastatic castrate resistant setting. While prostate specific antigen (PSA) serves as a useful biomarker newly diagnosed patients or those on androgen deprivation therapy, its efficacy monitoring under PSMA-directed therapy remains unclear. This underscores critical gap: absence established biomarkers for...
Abstract Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC), which affects 50,000 new patients annually in the United States, is associated with less than 50% 5-year survival. HNSCC tumors display increased glycolysis, even presence of oxygen. Consequently, there an increase lactic acid (LA) production. However, effect tumor microenvironment mechanisms whereby survive highly acidic conditions remain unknown. consist up to 80% tumor-associated fibroblasts (TAFs). We...