A5077254348- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Research and Treatments
- Cardiac tumors and thrombi
- Metabolism, Diabetes, and Cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Risk Factors
- Cancer-related Molecular Pathways
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Lung Cancer Treatments and Mutations
- Pharmaceutical industry and healthcare
- Cardiovascular Effects of Exercise
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cancer Cells and Metastasis
- Pharmaceutical Economics and Policy
Hamilton Medical Center
2024
Cardiovascular Research Associates
2023
Johns Hopkins Hospital
2020-2021
Johns Hopkins University
2020
Johns Hopkins Bayview Medical Center
2020
Stanford University
2016-2019
Stanford Medicine
2016-2019
VA Palo Alto Health Care System
2017-2019
University of Pittsburgh
2015-2018
Cardiovascular Institute of the South
2017-2018
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts (CAF). We previously reported that CAF-secreted HGF facilitates progression; however, very little known about the role CAFs in metabolism. Here, we demonstrate increases extracellular lactate levels via upregulation glycolysis. induced basic FGF (bFGF) secretion from HNSCC. were...
Direct oral anticoagulants (DOACs) have strict dosing guidelines, but recent studies indicate that inappropriate is common, particularly in chronic kidney disease (CKD), for which it has been reported to be as high 43%. Since 2011, the Veterans Health Administration (VA) implemented anticoagulation management programs DOACs, generally led by pharmacists, previously shown improve medication adherence.We investigated prevalence of overdosing and underdosing DOACs VA.Using data from TREAT-AF...
Abstract Background An increasing number of methods are being used to map atrial fibrillation (AF), yet the sensitivity identifying potential localized AF sources these novel unclear. Here, we report a comparison two approaches based upon (1) electrographic flow mapping and (2) phase in multicenter registry patients whom ablation terminated persistent AF. Methods Fifty‐three consecutive with an international were enrolled. Electrographic (EGF) applied multipolar simultaneous electrograms...
Abstract Objective To investigate mechanisms by which atrial fibrillation (AF) may terminate during ablation near the pulmonary veins before are isolated (PVI). Introduction It remains unstudied how AF PVs isolated, or patients with PV reconnection can be arrhythmia‐free. We studied in whom antral terminated PVI, using two independent mapping methods. Methods referred for ablation, biatrial contact basket electrograms were both an activation/phase method and a second validated reported not...
Background Although guidelines for antiarrhythmic drug therapy in atrial fibrillation ( AF ) were published 2006, it remains uncertain whether adherence to these affects patient outcomes. Methods and Results We retrospectively evaluated the records of 5976 consecutive patients who prescribed at least 1 between 2006 2013. Patients with or more drugs that did not comply guideline recommendations comprised non–guideline‐directed group (=2920); remainder constituted guideline‐directed (=3056)....
Background: Amiodarone is often prescribed in the management of atrial fibrillation (AF) but known to cause significant end-organ toxicities. In this study, we examined impact amiodarone on all-cause mortality AF patients with structurally normal hearts. Methods: We performed a retrospective cohort analysis all hearts who were antiarrhythmic drugs (AAD) for rhythm control at our institution from 2006 2013 (n = 2,077). Baseline differences between (AMIO: n 403) and other AADs (NON-AMIO:...
Although implantation of cardiac implantable electronic devices (CIEDs) in patients receiving warfarin is well studied, limited data are available on the use oral factor Xa inhibitors this setting.Using from Rivaroxaban Once Daily Oral Direct Factor Inhibition Compared with Vitamin K Antagonism for Prevention Stroke and Embolism Trial Atrial Fibrillation (ROCKET AF) (n=14 264), we compared baseline characteristics clinical outcomes atrial fibrillation randomized to rivaroxaban versus who did...
Background: Patients with atrial fibrillation (AF) treated percutaneous coronary intervention (PCI) require multiple antithrombotic therapies. The optimal strategy is debated suggesting increased treatment variation. This study sought to characterize site-level variation in therapies AF patients after PCI and determine the association outcomes. Methods: Using retrospective TREAT-AF (The Retrospective Evaluation Assessment of Therapies AF) from Veterans Health Administration, newly diagnosed,...
Localized drivers are proposed mechanisms for persistent atrial fibrillation (AF) from optical mapping of human atria and clinical studies AF, yet controversial because fluctuate ablating them may not terminate AF. We used wavefront field to test the hypothesis that AF drivers, if concurrent, interact produce fluctuating areas control explain their appearance/disappearance acute impact ablation.We recruited 54 patients an international registry in whom terminated by targeted ablation....
We examined the effect of novel oral anticoagulants (NOACs) compared to warfarin on risk death or stroke in atrial fibrillation (AF) patients every day clinical practice.We a cohort 2,836 AF patients, whom 2,253 were prescribed and 583 an NOAC. Patients with glomerular filtration rate < 30 mg/mL history significant valvular heart disease excluded. followed primary end points stroke. Propensity matching was used adjust for differences baseline characteristics between groups.Compared NOAC...
Abstract We present a case of an LA mass presenting with embolic stroke in young patient who had undergone chemotherapy for synovial sarcoma. TTE showed elongated prolapsing into the LV. Surgical resection revealed arose from RSPV and consisted necrotic hyalinized tissue.
Abstract Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC), which affects 50,000 new patients annually in the United States, is associated with less than 50% 5-year survival. HNSCC tumors display increased glycolysis, even presence of oxygen. Consequently, there an increase lactic acid (LA) production. However, effect tumor microenvironment mechanisms whereby survive highly acidic conditions remain unknown. consist up to 80% tumor-associated fibroblasts (TAFs). We...
Introduction: Women with atrial fibrillation (AF) have a higher risk of ischemic stroke than men. Hypothesis: The primary hypothesis is that rates anticoagulation differ between men and women AF. secondary difference in rate results stroke-free survival Methods: We analyzed the records 5,976 consecutive AF patients who were prescribed at least one antiarrhythmic drug 2006 2013. Time to clinical outcome events was assessed using analysis method adjusted for covariates Cox regression. Results:...
•Cardiac heterotopia (noncardiac tissue in the heart) is a rare condition.•It thought to be related disrupted cell migration during development.•Cardiac can give rises masses that present with symptoms decades later.