A5002470401- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Cancer, Stress, Anesthesia, and Immune Response
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Intensive Care Unit Cognitive Disorders
- Acupuncture Treatment Research Studies
- Nausea and vomiting management
- Anesthesia and Pain Management
- Cancer-related molecular mechanisms research
- Myofascial pain diagnosis and treatment
- Kruppel-like factors research
- Music Therapy and Health
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Inflammatory mediators and NSAID effects
- Ginkgo biloba and Cashew Applications
- Calpain Protease Function and Regulation
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Computational Drug Discovery Methods
- Neurological Disease Mechanisms and Treatments
- Monoclonal and Polyclonal Antibodies Research
Guizhou Provincial People's Hospital
2016-2024
Guizhou University
2021-2024
Fourth Affiliated Hospital of Guangxi Medical University
2024
Xinjiang Medical University
2021
First Affiliated Hospital of Xinjiang Medical University
2021
Guiyang Medical University
2017
Wenzhou Medical University
2009-2015
Yichang Central People's Hospital
2015
China Three Gorges University
2015
Propofol is commonly used for anaesthesia during surgery, and accumulating evidence has demonstrated that propofol associated with tumour suppression. For example, down-regulates the expression of vascular endothelial growth factor to inhibit pancreatic cancer malignancy. However, deeper insights into its underlying mechanism are needed. In this study, we treated cell lines Panc1 Bxpc3 or without propofol. Cell proliferation, migration invasion were evaluated using...
In current study we assessed the effect of transcutaneous electrical acupoint stimulation (TEAS) on quality early recovery in patients undergoing gynecological laparoscopic surgery.
To investigate the potential anti-tumoral properties of propofol in pancreatic cancer and elucidate underlying mechanisms.The relative expression ADAM metallopeptidase domain 8 (ADAM8) response to hypoxia Panc1 cells was analyzed by western blotting. The enzymatic activity determined fluorescence release from PEPDAB013 decomposition. Cell growth measured via cell counting viability using CCK-8 kit. migrative capacity evaluated transwell adhesion assay. abundance angiogenesis-related markers...
Acupuncture and related techniques are used worldwide to alleviate pain; however, their mechanisms of action still not fully understood. In the present study, we investigated effect transcutaneous electrical acupuncture point stimulation (TEAS) at different frequencies in a chronic constriction injury (CCI) model neuropathic pain rats.CCI was induced by ligating common sciatic nerve, which produced pain. 18 male Sprague-Dawley rats with CCI were randomly divided into three groups (n=6 each)...
Abstract Purpose Breast cancer is the most frequent in women with significant death rate. Morbidity associated drug resistance and metastasis. Development of novel drugs unmet need. The aim this study to show potent anti-neoplastic activity UM171 compound on breast cells its mechanism action. Methods inhibitory effect several (BC) cell lines was examined using MTT colony-forming assays. Cell cycle apoptosis assays were utilized determine BC proliferation survival. Wound healing scratch...
Abstract Purpose Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and several studies demonstrate that STAT3 has critical roles throughout course PDAC pathogenesis. Methods TCGA, microarray, immunohistochemistry data from a cohort were used for clinical analyses. Panc89 cells with ADAM8 knockout, re-expression mutants, Panc1 overexpressing generated. Gene expression analyses ADAM8, STAT3, long non-coding (lnc) RNA NEAT1, miR-181a-5p ICAM1 performed by quantitative...
We attempted to investigate cardioprotection of electroacupuncture (EA) for enhanced recovery after surgery on patients undergoing heart valve replacement with cardiopulmonary bypass. Forty-four acquired were randomly allocated the EA group or control group. Patients in received stimulus at bilateral Neiguan (PC6), Ximen (PC4), Shenting (GV24), and Baihui (GV20) acupoints twenty minutes before anesthesia induction end surgery. The primary point was effect postoperatively secondary endpoints...
Pain during cesarean delivery is one of the more common reasons for a successful medicolegal claim. However, creating an extensive block area can result in hypotension, so determining precise dose local anesthetic critical.Investigate effects parturient height on median effective (ED50) intrathecally-administered ropivacaine.Prospective cross-sectional analytic study.Anesthesiology department provinicial hospital China.Parturients undergoing under combined spinal and epidural anesthesia were...
Aim Postoperative cognitive dysfunction is often observed in older patients. Previous reports described the link between postoperative and general anesthetics, such as sevoflurane, but exact mechanism remains unclear. We therefore sought to characterize effects of sevoflurane on hippocampal‐dependent functions, well hippocampal plasticity, delineate underlying mechanisms. Methods Behavioral assays including novel object recognition test Morris water maze were carried out assess performance...
Neuropathic pain is a well-known type of chronic caused by damage to the nervous system. Until recently, researchers have found that increased generation reactive oxygen species (ROS) contributes development exaggerated hypersensitivity during neuropathic pain.In this study, we investigated antinociceptive efficacy Ginkgo biloba extract (EGb761) in constriction injury (CCI) model rats. To explore underlying mechanisms, effects EGb761 on excitability dorsal root ganglion (DRG) neurons and...
Background: Acupuncture has been used to treat myofascial pain syndrome (MPS) for 2000 years in China, but its mechanisms are still not entirely clear. In the present study, we explored effects of transcutaneous electrical acupuncture point stimulation (TEAS) at an Ashi on expression phosphorylated c-Jun N-terminal kinase (p-JNK) dorsal root ganglion (DRG) using a rat model MPS. Methods: 32 rats were divided into four groups: normal, MPS, MPS+TEAS and MPS+sham- TEAS. MPS was produced by...
Background. In the current study, we assessed effect of ultrasound-guided internal branch upper laryngeal nerve (USG-guided iSLN) block combined with general anesthesia on perioperative sore throat (POST), cough, hoarseness voice, intraoperative hemodynamic changes, and quality early recovery for patients undergoing suspension laryngoscopy vocal cord polypectomy (SLVCP). Methods. This was a randomized controlled trail. Eighty patients, aged from 18 to 70 years old, ASA I ∼ II, scheduled by...
Numerous studies have demonstrated that anesthetics’ exposure to neonates imposes toxicity on the developing brain but underlying mechanisms need be further elucidated. Our present study aimed explore role of small conductance Ca 2+ -activated potassium channel type2 in memory and learning dysfunction caused by exposing sevoflurane. Postnatal day 7 Sprague-Dawley rats hemagglutinin-tagged transfected COS-7 cells were exposed sevoflurane trafficking channels was analyzed; furthermore, ability...
<title>Abstract</title> <bold>Purpose:</bold> Breast cancer is the most frequent in women with significant death rate. Morbidity associated drug resistance and metastasis. Development of novel drugs unmet need. The aim this study to show potent anti-neoplastic activity UM171 compound on breast cells its mechanism action. <bold>Methods:</bold> inhibitory effect several (BC) cell lines was examined using MTT colony forming assays. Cell cycle apoptosis assays were utilized determine BC...
<title>Abstract</title> Purpose Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. Several studies demonstrate that ADAM8 and STAT3 are critical for PDAC progression potential therapeutic targets. Methods TGCA, microarray, immunohistochemistry data from a cohort were used clinical analyses. Panc89 cells with knockout, re-expression mutants, Panc1 overexpressing generated. Gene expression analyses ADAM8, STAT3, long non-coding (lnc) RNA NEAT1, miR-181a-5p ICAM1...
Objective To evaluate the effect of electroacupuncture(EA)on postoperative outcome in patients undergoing cardiac valve replacement with cardiopulmonary bypass(CPB). Methods Forty-four both sexes, aged 18-55 yr, body mass index 18-25 kg/m2, American Society Anesthesiologists physical status Ⅲ, New York Heart Association Ⅱ or scheduled for elective CPB, were divided into 2 groups(n=22 each)using a random number table: control group(group C)and group EA.In EA, received EA stimulation...
Objective: Neuropathic pain is a prevalent desease that greatly impairs the patients quality of life. A lack understanding its aetiology, inadequate relief, and development tolerance potential toxicity classical antinociceptives warrant investigation newer agents to relieve this pain. The aim present study was explore antinociceptic effect curcumin on expression N-methyl-D-aspartate (NMDA) receptor in spinal dorsal horn root ganglion chronic constriction injury (CCI) mode neuropathic rats....
Objective To evaluate the effect of curcumin on diabetic neuropathic pain (DNP) in rats. Methods Forty-eight male SD rats weighing 200-230 g were randomly divided into 6 groups ( n = 8 each) : group Ⅰ normal control (group C); Ⅱ DNP D) ; Ⅲ DNP+ DMSO (solvent curcumin) DD) and Ⅳ , Ⅴ Ⅵ + 50, 100 or 200 mg/kg DC50, 100, ). Diabetes was induced with intraperitoneal (IP) streptozocin 75 -Ⅵ. Curcumin given IP once a day for 14 consecutive days starting from d after respectively. Venous blood...