A5043623665- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Heme Oxygenase-1 and Carbon Monoxide
- Chronic Obstructive Pulmonary Disease (COPD) Research
- T-cell and B-cell Immunology
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Long-Term Effects of COVID-19
- Dengue and Mosquito Control Research
- Mitochondrial Function and Pathology
- Science, Research, and Medicine
- Eosinophilic Esophagitis
- SARS-CoV-2 and COVID-19 Research
- Single-cell and spatial transcriptomics
- S100 Proteins and Annexins
- COVID-19 and healthcare impacts
- Criminal Justice and Corrections Analysis
- Historical and Scientific Studies
- Eosinophilic Disorders and Syndromes
- Vitamin D Research Studies
- Metalloenzymes and iron-sulfur proteins
University of Pittsburgh
2013-2025
University of Pittsburgh Medical Center
2017-2024
Centre Hospitalier Universitaire de Sherbrooke
2021
Pulmonary and Allergy Associates
2017-2021
Emory University
2020
Assistance Publique – Hôpitaux de Paris
2009
Hôpital Ambroise-Paré
2009
We previously showed that Th1/type 1 inflammation marked by increased IFN-γ levels in the airways can be appreciated 50% of patients with severe asthma, despite high dose corticosteroid (CS) treatment. hypothesized a downstream target IFN-γ, CXCL10, which recruits Th1 cells via cognate receptor CXCR3, is an important contributor to Th1high asthma and CS unresponsiveness. show CXCL10 mRNA closely associated IFNG BAL asthmatics also mice subjected model, both context high-dose The inability...
Severe asthma (SA) is a significant problem both clinically and economically, given its poor response to corticosteroids (CS). We recently reported complex type 1-dominated (IFN-γ-dominated) immune in more than 50% of severe asthmatics despite high-dose CS treatment. Also, IFN-γ was found be critical for increased airway hyperreactivity (AHR) our model SA. The transcription factor IRF5 expressed M1 macrophages can induce Th1/Th17 cocultured human T cells. Here we show markedly higher...
Aberrant immune response is a hallmark of asthma, with 5-10% patients suffering from severe disease exhibiting poor to standard treatment. A better understanding the responses contributing heterogeneity critical for improving asthma management. T cells are major players in orchestration both mild and disease, but it unclear whether specific cell subsets influence symptom duration. Here we show significant association airway CD8+ effector memory re-expressing CD45RA (TEMRAs), not CD45RO+ or...
Carbon monoxide poisoning affects 50,000 per year in the United States alone. Mortality is approximately 3%, and up to 40% of survivors suffer from permanent neurocognitive affective deficits. Hyperbaric oxygen therapy has shown benefit on reducing long-term neurologic sequelae carbon but not demonstrated improved survival. The objective this study assess efficacy hyperbaric for acute mortality using a large clinical databank.Retrospective analysis.University Pittsburgh Medical Center...
Background Clustering key clinical characteristics of participants in the Severe Asthma Research Program (SARP), a large, multicenter prospective observational study patients with asthma and healthy controls, has led to identification novel phenotypes. Purpose To determine whether quantitative CT (qCT) could help distinguish between Materials Methods A retrospective cross-sectional analysis was conducted use qCT images (maximal bronchodilation at total lung capacity [TLC], or inspiration,...
Rationale: Corticosteroid-responsive type 2 (T2) inflammation underlies the T2-high asthma endotype. However, we hypothesized that 1 (T1) inflammation, possibly related to viral infection, may also influence corticosteroid response. Objectives: To determine frequency and within-patient variability of T1-high, T2-high, T1/T2-high endotypes whether virally influenced T1-high disease influences response in asthma. Methods: Patients SARP-3 (Severe Asthma Research Program-3) had sputum collected...
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Introduction Acute mortality from carbon monoxide poisoning is 1–3%. The long-term risk of survivors doubled compared to age-matched controls. Cardiac involvement also increases risk. We built a clinical score identify monoxide-poisoned patients at for acute and mortality.Methods performed retrospective analysis. identified 811 adult in the derivation cohort, 462 validation cohort. utilized baseline demographics, laboratory values, hospital charge transactions, discharge disposition,...
ABSTRACT The prevalence, inter-relationships, and longitudinal behavior of type 1 (T1) 2 (T2) immune responses in asthma are uncertain, as is the role viruses determinants these responses. Here, we performed whole transcriptome network analysis on sputum cells collected from Severe Asthma Research Program (SARP)-3 patients before after treatment with intramuscular corticosteroid again at 3-year follow-up visits. We used to analyze whole-transcriptome gene expression metagenomic RNA-seq data...