A5017458077- Gut microbiota and health
- Parkinson's Disease Mechanisms and Treatments
- Infant Nutrition and Health
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Climate Change and Health Impacts
- Plant Pathogens and Fungal Diseases
- Dysphagia Assessment and Management
- Food Allergy and Anaphylaxis Research
- Metallurgy and Material Science
- Child Nutrition and Feeding Issues
- Molecular Biology Techniques and Applications
- Pediatric health and respiratory diseases
- Health, Environment, Cognitive Aging
- Organ and Tissue Transplantation Research
- Infant Health and Development
- Microbial Community Ecology and Physiology
- Diet and metabolism studies
- Nutritional Studies and Diet
Inserm
2021-2024
Sorbonne Université
2023-2024
Centre d'Immunologie et des Maladies Infectieuses
2020-2024
Centre National de la Recherche Scientifique
2024
University of Luxembourg
2024
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2020
Due to the increasing importance of exposome in environmental epidemiology, feasibility and usefulness an Environmental Data Management System (EDMS) using Open was evaluated. The EDMS includes data from 10 European cities (Celje (Slovenia), Łódź (Poland), Manchester (UK), Palermo (Italy), Paris (France), Porto (Portugal), Regensburg (Germany), Reus (Spain), Rijeka (Croatia), Thessaloniki (Greece)) about external non-specific specific factors at city or country level (2017-2020). Findings...
Abstract High-throughput phylogenetic 16S rRNA gene analysis has permitted to thoroughly delve into microbial community complexity and understand host-microbiota interactions in health disease. The comprises sample collection storage, genomic DNA extraction, amplification, high-throughput amplicon sequencing bioinformatic analysis. Low biomass microbiota samples (e.g. biopsies, tissue swabs lavages) are receiving increasing attention, but optimal standardization for of low yet be developed....
Abstract Background Interest for the study of gut mycobiota in relation with human health and immune homeostasis has increased last years. From this perspective, new tools to immune/fungal interface are warranted. Systemic humoral responses could reflect dynamic relationships between immunity. Using a novel flow cytometry technology (Fungi-Flow) determine immunoglobulin (Ig) fungi, we studied systemic anti-commensal Results The Fungi-Flow method allows sensitive specific measurement IgG...
Uterus transplantation (UTx) is a treatment option for women with absolute uterine factor infertility. More than 100 UTx procedures have been performed, and the procedure being accepted into clinical practice.1-3 However, rejection, which typically asymptomatic, occurs in approximately 60% of patients4; specific biomarkers function rejection are lacking.5 Current practice assessing graft involves cervical biopsies T-lymphocyte infiltration between stroma epithelium appraising perivascular...
Alterations of gut microbiome structure have been observed in a panoply human diseases including neurodegeneration. However, the ecological and functional deficits dysbiosis yet to be understood. Here, using integrated multi-omics (metagenomics metatranscriptomics), we resolve gene co-expression networks individuals with Parkinson′s disease (PD) healthy individuals. We uncover network modules high closeness degree centrality that represent core functions, identify key features lost PD. More...
Summary Parkinson’s disease (PD) is associated with gut microbiome shifts, but the functional consequences remain unclear. Here, we use an integrated multi-omics approach to compare microbiomes of individuals PD and prodromal as well healthy individuals. After analyzing each omics, meta-metabolomic was selected inform analysis it represents most discriminatory robust ome. We identified 11 metabolites that were differentially abundant between groups, amongst which β-glutamate increased in PD,...
Summary The gut microbiota of 2-3 month-old infants is associated with later pre-allergic signs, while the at time allergic manifestation not. We hypothesized that infant and immune system are primed shortly after birth, this influenced by maternal transfer humoral immunity. investigated association between outcomes composition immunity to 2 months, years-of-age. Meconium clustered into three groups dominated Escherichia , Enterococcus mixed genera, respectively. cluster was protection...