A5069438892- Gut microbiota and health
- Parkinson's Disease Mechanisms and Treatments
- Genomics and Phylogenetic Studies
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- Regional Socio-Economic Development Trends
- Microbial Community Ecology and Physiology
- Advanced Power Generation Technologies
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Protein purification and stability
- Nutritional Studies and Diet
- Plant Pathogenic Bacteria Studies
- Machine Learning in Bioinformatics
- Antibiotic Resistance in Bacteria
- Educational Methods and Teacher Development
- Bacteriophages and microbial interactions
- Dysphagia Assessment and Management
- Bioinformatics and Genomic Networks
- Biomedical Text Mining and Ontologies
- Educational Practices and Challenges
- Educational Innovations and Challenges
- Water Resources and Management
- Sociopolitical Dynamics in Russia
- Arctic and Russian Policy Studies
University of Luxembourg
2022-2024
Sirius University of Science and Technology
2024
Laboratoire des Sciences de l’Information et de la Communication
2023
Luxembourg Institute of Socio-Economic Research
2021
Abstract Patients with Parkinson’s disease (PD) exhibit differences in their gut microbiomes compared to healthy individuals. Although have most commonly been described the abundances of bacterial taxa, changes viral and archaeal populations also observed. Mechanistic links between microbes PD pathogenesis remain elusive but could involve molecules that promote α-synuclein aggregation. Here, we show 2-hydroxypyridine (2-HP) represents a key molecule for PD. We observe significantly elevated...
Abstract A common approach to genome annotation involves the use of homology-based tools for prediction functional role proteins. The quality annotations is dependent on reference data used, as such, choosing appropriate sources crucial. Unfortunately, no single source can be universally considered gold standard, thus using multiple references could potentially increase and coverage. However, this comes with challenges, particularly due introduction redundant exclusive annotations. Through...
Despite important ecological roles posited for virocells (i.e., cells infected with viruses), studying individual in situ is technically challenging. We introduce here a novel correlative microscopic approach to study the ecophysiology of virocells. By conducting concerted virusFISH, 16S rRNA FISH, and scanning electron microscopy interrogations uncultivated archaea, we linked morphologies various altiarchaeal corresponding phylogenetic signals indigenous virus infections. While uninfected...
The human gastrointestinal tract contains diverse microbial communities, including archaea. Among them,
Therapeutic monoclonal antibodies (mAbs) are crucial in modern medicine due to their effectiveness treating various diseases. However, the structural complexity of mAbs, particularly glycosylation patterns, presents challenges for quality control and biosimilarity assessment. This study explores use upper-hinge middle-up (UHMU)-level ultra-high-performance liquid chromatography-high-resolution mass spectrometry (LC-HRMS) analysis improve N-glycan profiling mAbs. Two specific enzymes, known...
Alterations of gut microbiome structure have been observed in a panoply human diseases including neurodegeneration. However, the ecological and functional deficits dysbiosis yet to be understood. Here, using integrated multi-omics (metagenomics metatranscriptomics), we resolve gene co-expression networks individuals with Parkinson′s disease (PD) healthy individuals. We uncover network modules high closeness degree centrality that represent core functions, identify key features lost PD. More...
Summary Parkinson’s disease (PD) is associated with gut microbiome shifts, but the functional consequences remain unclear. Here, we use an integrated multi-omics approach to compare microbiomes of individuals PD and prodromal as well healthy individuals. After analyzing each omics, meta-metabolomic was selected inform analysis it represents most discriminatory robust ome. We identified 11 metabolites that were differentially abundant between groups, amongst which β-glutamate increased in PD,...
Abstract The human gastrointestinal tract contains diverse microbial communities, including archaea. Among them, Methanobrevibacter smithii represents a highly active and clinically relevant methanogenic archaeon, being involved in disorders, such as IBD obesity. Herein, we present an integrated approach using sequence structure information to improve the annotation of M. proteins advanced protein prediction tools, AlphaFold2, trRosetta, ProFunc, DeepFri. Of initial set 873 481 archaeal...
Abstract As part of the revisions our original manuscript, we performed 13 C-labelling experiments with cultures microorganism most strongly correlated 2-hydroxypyridine (2-HP), i.e. archaeal species Methanobrevibacter smithii . Although unlabelled 2-HP was detected in cultures, measurements by gas chromatography-mass spectrometry (GC-MS) indicated that M. not direct source as labelled measured. Further involving a solvent (deuterated pyridine) and faecal samples from study alongside use...
XOJKLP ПОТРЕБНОСТИ И ОЖИДАНИЯ ПЕДАГОГОВ РОССИИ В СФЕРЕ ОБУЧЕНИЯ ВОСПИТАНИЯ ШКОЛЬНИКОВ ПОЛИКУЛЬТУРНОЙ СРЕДЕ А
Introduction. The pedagogical need due to the migration situation in country actualizes for research on specifics of migrant children’s linguistic and socio-cultural adaptation regions. purpose is identify reliable significant differences problems educational environment federal districts Russian Federation. Materials methods. study involved 8,864 teachers (4,026 respondents were selected content analysis) working multicultural classes from 8 districts. used a method analysis, survey methods...
The paper presents the main results of assessing water quality Shlinsky reservoir for period 2015-2019. Based on analysis hydrochemical data obtained by standard chemical methods, according to 22 indicators. Monitoring until 2021 was carried out Dubna Ecoanalytic Laboratory. is located border Tver and Novgorod regions, part Vyshnevolotsk system. provides releases needs energy, transport improvement supply in Moscow. As a result study, priority pollutants were identified, assessed based...