A5038916618- Protein Structure and Dynamics
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Silk-based biomaterials and applications
- Calcium Carbonate Crystallization and Inhibition
- Genetics, Bioinformatics, and Biomedical Research
- Biochemical and Structural Characterization
- Bacteriophages and microbial interactions
- Various Chemistry Research Topics
- Analytical Chemistry and Chromatography
- Bone Tissue Engineering Materials
- Biochemical and Molecular Research
- Lipid Membrane Structure and Behavior
- Adhesion, Friction, and Surface Interactions
- COVID-19 Clinical Research Studies
- Enzyme Structure and Function
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Plant and Biological Electrophysiology Studies
- Advanced Biosensing Techniques and Applications
- Photoreceptor and optogenetics research
- Nanoparticles: synthesis and applications
- Aquaculture disease management and microbiota
- Advanced Proteomics Techniques and Applications
- thermodynamics and calorimetric analyses
University of California, Irvine
2020-2023
Fisk University
2021
Wright-Patterson Air Force Base
2018-2020
United States Air Force Research Laboratory
2018
Mimicking the designs found in proteins Natural combine a range of useful features, including chemical diversity, ability to rapidly switch between preprogrammed shapes, and hierarchy structures. Panganiban et al. designed random copolymers with polar nonpolar groups, using many features (see Perspective by Alexander-Katz Van Lehn). Their structures could serve as “broad spectrum” surfactants, able promote solubilization organic solvents help preserve functionality aqueous environments....
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands redirection of scientific efforts criteria organized research projects. international COVID19-NMR consortium seeks provide such new approaches gathering expertise worldwide. In particular, making available viral proteins RNAs will pave way understanding molecular components in detail. resources provided through are fully disclosed accelerate access exploitation. NMR...
The SARS-CoV-2 main protease (Mpro) is essential to viral replication and cleaves highly specific substrate sequences, making it an obvious target for inhibitor design. However, as any virus, subject constant neutral drift selection pressure, with new Mpro mutations arising over time. Identification structural characterization of variants thus critical robust Here we report sequence analysis, structure predictions, molecular modeling seventy-nine variants, constituting all clinically...
Mechanisms of biomaterial sclerotization in natural systems promise new insights into how the mechanical properties engineered materials may be dynamically modulated. One such example involves proteinaceous jaw marine sandworm, Nereis virens. Previously, N. virens were shown to modulated by Zn binding, a property that was proposed enabled presence histidine-rich protein, Nvjp-1. Here we demonstrate creation Nvjp-1-based hydrogels and show progressive these can accomplished with hierarchical...
The Droserasins, aspartic proteases from the carnivorous plant Drosera capensis, contain a 100-residue plant-specific insert (PSI) that is post-translationally cleaved and independently acts as an antimicrobial peptide. PSIs are of interest not only for their inhibition microbial growth, but also because they modify size lipid vesicles strongly interact with biological membranes. may therefore be useful modulating systems in NMR studies membrane proteins. Here we present expression...
Abstract The suckerin family of proteins, identified from the squid sucker ring teeth assembly, offers unique mechanical properties and potential advantages over other natural biomaterials. In this study, a small isoform, suckerin‐12, is used to create enzymatically crosslinked, macro‐scale hydrogels. Upon exposure specific salt conditions, suckerin‐12 hydrogels contracted into condensed state where are found be modulated by anion present. rate contraction correlate well with kosmotropic arm...
Minicollagens from cnidarian nematocysts are attractive potential building blocks for the creation of strong, lightweight and tough polymeric materials with dynamic reconfigurable crosslinking to modulate functionality. In this study, Hydra magnipapillata minicollagen-1 isoform was recombinantly expressed in bacteria, a high throughput purification protocol developed generate milligram levels pure protein without column chromatography. The resulting preparation demonstrated spectral...
The SARS-CoV-2 main protease (M pro ) is essential to viral replication and cleaves highly specific substrate sequences, making it an obvious target for inhibitor design. However, as any virus, subject constant selection pressure, with new M mutations arising over time. Identification structural characterization of variants thus critical robust Here we report sequence analysis, structure predictions, molecular modeling seventy-nine variants, constituting all clinically observed in this...
The Humboldt squid is one of the fiercest marine predators thanks in part to its sucker ring teeth that are biopolymer blends a protein isoform family called suckerin with compression strength rivals silkworm silk. Here, we focus on popular suckerin-12 understand what makes secondary structure this different water and potential role diverse physical chemical cross-linkings. By choosing salt post-treatment, accordance Hofmeister series, achieved film stability annealing comparable...
ABSTRACT A major challenge for science educators is teaching foundational concepts while introducing their students to current research. Here we describe an active learning module developed teach protein structure fundamentals supporting ongoing research in enzyme discovery. It can be readily implemented both entry-level and upper-division college biochemistry or biophysics courses. Preactivity lectures introduced of secondary provided context the projects, a homework assignment familiarized...
Abstract A major challenge for science educators is teaching foundational concepts while introducing their students to current research. Here we describe an active learning module developed teach protein structure fundamentals supporting ongoing research in enzyme discovery. It can be readily implemented both entry-level and upper-division college biochemistry or biophysics courses. Pre-activity lectures introduced of secondary provided context the projects, a homework assignment...